Yıl: 2005 Cilt: 2 Sayı: 3 Sayfa Aralığı: 173 - 185 Metin Dili: Türkçe

Formulation and characterization of a cosmetic multiple emulsion system containing macadamia nut oil and two anti aging agents

Öz:
Bu çalışmanın amacı, doğal bir yağ kullanarak, iki farklı cilt yaşlanmasını geciktirici madde içeren kararlı emülsiyon sistemini hazırlamaktır. Çok kararsız ve oksijen varlığında yapısının parçalandığı bilinen vitamin C, s/y/s çoklu emülsiyonun iç fazına katılmıştır. Bu şekilde, vitamin C'nin yavaş salım göstermesi ve çevresel etkenlerden korunduğu için etkisinin iyileştirilmesi beklenebilir. Yaşlanmayı geciktirici olarak kullanılan diğer madde buğday proteini ürünüdür. Her iki madde de dermiş'deki kolajen liflerinin sentezini arttırır. Dolayısıyla, tek formülasyonda iki maddeyi kullanarak sinerjik etki oluşturulabilir. Bu çalışmada, çoklu emülsiyonlar iki-basamaklı emülsiyon oluşturma yöntemi ile hazırlanmıştır. Hazırlanan emülsiyonlar etkin madde içermeyen temel formülasyon ve iç fazında vitamin C, dış fazında ise buğday proteini içeren for mülasy onlar dır. Seçilen yağ, genç cildin doğal bileşeni olan ve palmitoleik asiti yüksek miktarda içeren makademia fındık yağıdır. Temel formülasyon ve etkin maddeleri içeren formülasyon, farklı hızlandırılmış koşullarda 6 ay saklanmış ve özellikleri belirlenmiştir. Emülsiyon sistemlerin özelliklerini belirlemek için damlacık boyutu, pH, viskozite ve fiziksel değişimler test edilmiştir. Temel emülsiyonun tüm koşullarda etkin maddeleri içeren formülasyondan daha kararlı olduğu bulunmuştur.
Anahtar Kelime: İlaç bileşimleri Teknoloji, farmasötik Triticum Macadamia Yaşlanma Emülsiyonlar Askorbik asit Bitkisel preparasyonlar

Makademia fındık yağı ve iki yaşlanma karşıtı maddenin kozmetik çoklu emülsiyon sistemi halinde formülasyonu ve karakterizasyonu

Öz:
The purpose of the study was to prepare a stable multiple emulsion system containing two skin anti aging agents using a natural oil vitamin C, known to be a very unstable ingredient and is decomposed in the presence of oxygen, was entrapped in the internal aqueous phase of w/o/w multiple emulsion. In this way, vitamin C is expected to exhibit slow release and the effect of vitamin C can be improved as it has been protected from the external environment. The other ingredient, which is a product of wheat protein was also used as an anti aging agent. Both of the ingredients increase the synthesis of collagen fibers in the dermis. Therefore, a synergystic effect can be produced by using the two ingredients in one formulation. In this study, multiple emulsions were prepared by the two-step emulsification method. Basic formulation containing no active material and a formulation containing vitamin C in the internal aqueous phase and wheat protein in the oily phase were prepared. The oil selected was macadamia nut oil since it contains a high quantity of palmitoleic acid which is the natural ingredient of the young skin. Basic formulation as well as the formulation containing active ingredients were stored at different accelerated conditions for six months and characterized. Globule size, pH, viscosity and physical changes were tested to characterize the emulsion systems. Basic emulsion was found to be more stable at all the different conditions than the formulation containing the active ingredients.
Anahtar Kelime: Macadamia Drug Compounding Triticum Emulsions Aging Technology, Pharmaceutical Ascorbic Acid Plant Preparations

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA AKHTAR N, YAZAN Y (2005). Formulation and characterization of a cosmetic multiple emulsion system containing macadamia nut oil and two anti aging agents. Turkish Journal of Pharmaceutical Sciences, 2(3), 173 - 185.
Chicago AKHTAR Naveed,YAZAN Yasemin Formulation and characterization of a cosmetic multiple emulsion system containing macadamia nut oil and two anti aging agents. Turkish Journal of Pharmaceutical Sciences 2, no.3 (2005): 173 - 185.
MLA AKHTAR Naveed,YAZAN Yasemin Formulation and characterization of a cosmetic multiple emulsion system containing macadamia nut oil and two anti aging agents. Turkish Journal of Pharmaceutical Sciences, vol.2, no.3, 2005, ss.173 - 185.
AMA AKHTAR N,YAZAN Y Formulation and characterization of a cosmetic multiple emulsion system containing macadamia nut oil and two anti aging agents. Turkish Journal of Pharmaceutical Sciences. 2005; 2(3): 173 - 185.
Vancouver AKHTAR N,YAZAN Y Formulation and characterization of a cosmetic multiple emulsion system containing macadamia nut oil and two anti aging agents. Turkish Journal of Pharmaceutical Sciences. 2005; 2(3): 173 - 185.
IEEE AKHTAR N,YAZAN Y "Formulation and characterization of a cosmetic multiple emulsion system containing macadamia nut oil and two anti aging agents." Turkish Journal of Pharmaceutical Sciences, 2, ss.173 - 185, 2005.
ISNAD AKHTAR, Naveed - YAZAN, Yasemin. "Formulation and characterization of a cosmetic multiple emulsion system containing macadamia nut oil and two anti aging agents". Turkish Journal of Pharmaceutical Sciences 2/3 (2005), 173-185.