Synthesis and antifungal properties of some benzimidazole derivatives

KILIÇGİL, Ayhan Gülgün; altanlar, nurten

Synthesis and antifungal properties of some benzimidazole derivatives

Ayhan Gülgün KILIÇGİL, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)

Nurten ALTANLAR (Ankara Üniversitesi, Eczacılık Fakültesi, Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Chemistry

2 0

Yıl: 2006 Cilt: 30 Sayı: 2 Sayfa Aralığı: 223 - 228 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis and antifungal properties of some benzimidazole derivatives

Öz:

Some benzimidazole derivatives were synthesized and their in vitro antifungal activities were tested against Candida albicans, Candida glabrata and Candida krusei. Compounds 6 and 9 possessed activity comparable to fluconazole against C. albicans with a minimum inhibitory concentration of 12.5 $mu g/mL$.

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1.V.L. Khairnar, S.R. Lockhande, M.R. Patel and B.G. Khadse, Chemical Abstract 95, 203833h (1981).
2.L.L. Kruse, D.L. Ladd, P.B. Harrsch, F.L. McCabe, S.M. Mong, L. Faucette and R. Johnson, J. Med. Chem.32, 409-417 (1989).
3.I. Islam, E.B. Skibo, R.T. Dorr and D.S. Alberts, J. Med. Chem. 34, 2954-2961 (1991).
4.V.J. Habernickel, Drugs made in Germany, 35, 97 (1992).
5.T. Fukuda, T. Saito, S. Tajima, K. Shimohara and K. Ito, Arzneim.-Forsch./Drug Res. 34, 805-810 (1984).
6.H. Nakano, T. Inoue, N. Kawasaki, H. Miyataka, H. Matsumoto, T. Taguchi, N. Inagaki, H. Nagai and T.Satoh, Chem. Pharm. Bull. 47, 1573-1578 (1999).
7.B. Can-Eke, M.O. Puskullu, E. Buyukbingol and M. İşcan, Chemico-Biological Interactions 113, 65-77(1998).
8.C. Kuş, G. Ayhan-Kılcıgil, B. Can-Eke and M. İşcan, Arch. Pharm. Res. 27, 156-163 (2004).
9.G. Ayhan-Kılcıgil, C. Kuş, T. Çoban, B. Can-Eke and M. İşcan, Journal of Enzyme Inhibition and Medicinal Chemistry 19, 129-135 (2004).
10.H. Göker, G. Ayhan-Kılcıgil, M. Tunçbilek, C. Kuş, R. Ertan, E. Kendi, S. Özbey, M. Fort, C. Garcia and A. J.Farre, Heterocycles 51, 2561-2573 (1999).
11.A.E. Abdel-Rahman, A.M. Mahmoud, G.M. El-Naggar and H.A. El-Sherief, Pharmazie 38, 589-590 (1983).
12.F.S.G. Soliman, S.M. Rida, E.A.M. Badawey and T. Kappe/Arch. Pharm. 317, 951-958 (1984).
13.R,A. Coburn, M.T. Clark, R.T. Evans and R.J. Genco, J. Med. Chem. 30, 205-208(1987).
14.N.S. Habib, S. Abdel-Hamid and M. El-Hawash, Farmaco, 44, 1225-1232 (1989).
15.H. Göker, C. Kuş, D.W. Boykin, S. Yıldız and N. Artanlar, Bioorg. Med. Chem. 10, 2589-2596 (2002).
16.S. Özden, H. Karataş, S. Yıldız and H. Goker, Arch. Pharm. Pharm. Med. Chem. 337, 556-562 (2004).
17.S. Özden, D. Atabey, S.Yıldız and H. Göker, Bioorg. Med. Chem. 13, 1587-1597 (2005).
18.I. Küçükgüzel, G. Küçükgüzel, S. Rollas and M. Kiraz, Bioorg. Med. Chem. Letters 11, 1703-7007 (2001).
19.M.S. El-Gaby, J.A. Micky, N.M. Taha and M.A.M. El-Sharief, J. Chin. Chem. Soc. 49, 407-414 (2002).
20.C. Kuş, H. Göker, G. Ayhan, R. Ertan, N. Altanlar and A. Akın, II Farmaco 51, 413-417 (1996).
21.H. Göker, M. Tunçbilek, G. Ayhan and N. Altanlar, II Farmaco 53, 415-420 (1998).
22.G, Ayhan-Kılcıgil, M. Tunçbilek, N. Altanlar and H. Göker, II Farmaco 54, 562-565 (1999).
23.G. Ayhan-Kılcıgil and N. Altanlar, II Farmaco 58, 1345-1350 (2003).
24.H. Willitzer, D. Brauniger, D. Engelmann, D. Krebs, W. Ozegowski and M. Tonew, Pharmazie 33, 30-38(1978).
25.H.F. Ridley, R.G.W. Spickett and G.M.J. Timmis, Heterocyclic Chem. 2, 453-456 (1965).
26.D.F. Sahm and J.A. Washington, "Antibacterial Susceptibility Tests: Dilution Methods", in Manual of Clinical Microbiology, 5th ed., eds. A. Balowes, W.J. Hausler, K.L. Hermann and H.D. Shadomy, pp. 1105-1116, American Society for Microbiology, Washington DC, 1991.

APA	KILIÇGİL A, altanlar n (2006). Synthesis and antifungal properties of some benzimidazole derivatives. , 223 - 228.
Chicago	KILIÇGİL Ayhan Gülgün,altanlar nurten Synthesis and antifungal properties of some benzimidazole derivatives. (2006): 223 - 228.
MLA	KILIÇGİL Ayhan Gülgün,altanlar nurten Synthesis and antifungal properties of some benzimidazole derivatives. , 2006, ss.223 - 228.
AMA	KILIÇGİL A,altanlar n Synthesis and antifungal properties of some benzimidazole derivatives. . 2006; 223 - 228.
Vancouver	KILIÇGİL A,altanlar n Synthesis and antifungal properties of some benzimidazole derivatives. . 2006; 223 - 228.
IEEE	KILIÇGİL A,altanlar n "Synthesis and antifungal properties of some benzimidazole derivatives." , ss.223 - 228, 2006.
ISNAD	KILIÇGİL, Ayhan Gülgün - altanlar, nurten. "Synthesis and antifungal properties of some benzimidazole derivatives". (2006), 223-228.

APA	KILIÇGİL A, altanlar n (2006). Synthesis and antifungal properties of some benzimidazole derivatives. Turkish Journal of Chemistry, 30(2), 223 - 228.
Chicago	KILIÇGİL Ayhan Gülgün,altanlar nurten Synthesis and antifungal properties of some benzimidazole derivatives. Turkish Journal of Chemistry 30, no.2 (2006): 223 - 228.
MLA	KILIÇGİL Ayhan Gülgün,altanlar nurten Synthesis and antifungal properties of some benzimidazole derivatives. Turkish Journal of Chemistry, vol.30, no.2, 2006, ss.223 - 228.
AMA	KILIÇGİL A,altanlar n Synthesis and antifungal properties of some benzimidazole derivatives. Turkish Journal of Chemistry. 2006; 30(2): 223 - 228.
Vancouver	KILIÇGİL A,altanlar n Synthesis and antifungal properties of some benzimidazole derivatives. Turkish Journal of Chemistry. 2006; 30(2): 223 - 228.
IEEE	KILIÇGİL A,altanlar n "Synthesis and antifungal properties of some benzimidazole derivatives." Turkish Journal of Chemistry, 30, ss.223 - 228, 2006.
ISNAD	KILIÇGİL, Ayhan Gülgün - altanlar, nurten. "Synthesis and antifungal properties of some benzimidazole derivatives". Turkish Journal of Chemistry 30/2 (2006), 223-228.