Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives

ERTAN, Rahmiye; DÜNDAR, Bozdağ Oya; ALTANLAR, Nurten; ÜNLÜSOY, Ceylan Meltem

Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives

Ceylan Meltem ÜNLÜSOY, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)

Bozdağ Oya DÜNDAR, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)

Nurten ALTANLAR, (Ankara Üniversitesi, Eczacılık Fakültesi, Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Rahmiye ERTAN (Ankara Üniversitesi, Eczacılık Fakültesi, Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Chemistry

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Yıl: 2006 Cilt: 30 Sayı: 3 Sayfa Aralığı: 355 - 360 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives

Öz:

A new series of thiazolyl thiazolidine-2,4-dione (Va-f) were synthesized and their structures were elucidated by IR, $^1H$-NMR, mass spectra and elementary analysis. The synthesized compounds were tested for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus subtilis and Escherichia coli. Compounds Va-b, Vd-f showed high activity against Escherichia coli comparable to ampicillin.

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1.F.C. Brown, Chem. Rev. 61, 463-521 (1961).
2.M.C.A. DeLima, D.L.B. Costa, A.J.S. Goes, S.L. Galdino, I.R. Pitta and C. Luu-Duc, Pharmazie 47, 182-184 (1992).
3.M. Strumvoll and H.U. Haring, Ann. Med. 34: 217-222 (2002).
4.O. Bozdağ-Dündar, E.J. Verspohl, A. Waheed and R. Ertan, Arzneim.-Forsch./Drug Res. 53, 831-836 (2003).
5.A. Andreani, M. Rambaldi, A. Locatelli, R. Leoni, M. Bossa, I. Chiericozzi, G. Galatulas and A. Salvatore,Eur. J. Med. Chem. 28, 825-829 (1993).
6.S.A.H. El-Feky, Pharmazie 48, 894-896 (1993).
7.P.C. Unangst, D.T. Connor, W.A. Cetenko, R.J. Sorenson, J.C. Sircar, C.D. Wright, D.J. Schrier and R.D.Dyer, Bioorg. Med. Chem. Lett. 3, 1729-1734 (1993).
8.R.C. Sup, R.Y. Sup and C.W. Bang, Korean J. Med. Chem. 5, 72-75 (1995).
9.N. Agarwal, S. Kumar, A.K. Srivastava and P.C. Sarkar, Ind. J. Het. Chem. 6, 291-294 (1997).
10.I.M. Labouta, H.M. Salama, N.H. Eshba, O. Kader and E. El-Chrbini, Eur. J. Med. Chem. 22, 485-489(1987).
11.S. Athmani, M. F. Farhat, B. and J. Iddon, Chem. Soc. Perkin Trans. 1, 973-977 (1992).
12.N. Debski, W. Hanefeld and M. Schlitzer, J. Heterocyclic Chem. 34, 1427-1429 (1997).
13.C. Lo and E.Y. Shropshire, J. Org. Chem. 22, 999-1001 (1957).
14.D.L.B. Costa, J. Chantarel, M.C. Alves DeLima, J.F.C. Albuquerque, R.M.O. Lima, S.L. Galdino, I.R. Pitta and C. Luu-Duc, J. Pharm. Belg. 50, 5-10 (1995).
15.A.W. Bauer, W.M.M. Kirby, J.C. Sherris and M. Turck, Am. Clin. Pathol. 45, 493-496 (1966).

APA	ÜNLÜSOY C, DÜNDAR B, ALTANLAR N, ERTAN R (2006). Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. , 355 - 360.
Chicago	ÜNLÜSOY Ceylan Meltem,DÜNDAR Bozdağ Oya,ALTANLAR Nurten,ERTAN Rahmiye Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. (2006): 355 - 360.
MLA	ÜNLÜSOY Ceylan Meltem,DÜNDAR Bozdağ Oya,ALTANLAR Nurten,ERTAN Rahmiye Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. , 2006, ss.355 - 360.
AMA	ÜNLÜSOY C,DÜNDAR B,ALTANLAR N,ERTAN R Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. . 2006; 355 - 360.
Vancouver	ÜNLÜSOY C,DÜNDAR B,ALTANLAR N,ERTAN R Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. . 2006; 355 - 360.
IEEE	ÜNLÜSOY C,DÜNDAR B,ALTANLAR N,ERTAN R "Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives." , ss.355 - 360, 2006.
ISNAD	ÜNLÜSOY, Ceylan Meltem vd. "Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives". (2006), 355-360.

APA	ÜNLÜSOY C, DÜNDAR B, ALTANLAR N, ERTAN R (2006). Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. Turkish Journal of Chemistry, 30(3), 355 - 360.
Chicago	ÜNLÜSOY Ceylan Meltem,DÜNDAR Bozdağ Oya,ALTANLAR Nurten,ERTAN Rahmiye Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. Turkish Journal of Chemistry 30, no.3 (2006): 355 - 360.
MLA	ÜNLÜSOY Ceylan Meltem,DÜNDAR Bozdağ Oya,ALTANLAR Nurten,ERTAN Rahmiye Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. Turkish Journal of Chemistry, vol.30, no.3, 2006, ss.355 - 360.
AMA	ÜNLÜSOY C,DÜNDAR B,ALTANLAR N,ERTAN R Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. Turkish Journal of Chemistry. 2006; 30(3): 355 - 360.
Vancouver	ÜNLÜSOY C,DÜNDAR B,ALTANLAR N,ERTAN R Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives. Turkish Journal of Chemistry. 2006; 30(3): 355 - 360.
IEEE	ÜNLÜSOY C,DÜNDAR B,ALTANLAR N,ERTAN R "Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives." Turkish Journal of Chemistry, 30, ss.355 - 360, 2006.
ISNAD	ÜNLÜSOY, Ceylan Meltem vd. "Synthesis and antimicrobial activity of some new 3-substituted benzyl-5-(4-chloro-2-piperidin-1yl- thiazole-5-yl-methylene)-thiazolidine-2,4-dione derivatives". Turkish Journal of Chemistry 30/3 (2006), 355-360.