Yıl: 2005 Cilt: 15 Sayı: 3 Sayfa Aralığı: 138 - 152 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Kadın ve erkek beyninin farklılıkları

Öz:
Kadın ve erkeklerin beyin işlevleri arasında bazı farklılıkların olduğu son yıllardaki bilimsel çalışmalarla ortaya konmuştur. Bunun dışında kadın ve erkek beyninin yapısal, fizyolojik ve biyokimyasal olarak da bazı farklılıklar gösterdiği bilinmektedir. Ancak cinsiyetler arasındaki işlevsel farklılıkların bu yapısal ya da biyokimyasal farklılıklardan kaynaklanıp kaynaklanmadığı çok belirgin değildir. Beynin yapısında ve işlevlerinde görülen cinsiyete özgü bu iki yönlülüğün (dimorfizm) ve cinsel kimlik ve yönelimin gelişiminin büyük oranda doğumdan önceki hassas bir dönemde beynin maruz kaldığı gonadal steroidlerin tür ve düzeyine bağlı olduğu düşünülmektedir. Bu yazıda beynin cinsiyetler arasındaki işlevsel ve yapısal farklılıkları gözden geçirilecek ve bu farklılıkların embriyolojik ve evrimsel temellerine de değinilecektir.
Anahtar Kelime: Beyin Cinsiyet kimliği Cinsel davranış Kadın Erkek

Konular: Kadın Araştırmaları

Differences between male and female brains

Öz:
Recent scientific investigations have revealed some considerable differences in the brain functions of women and men. It is known that male and female brains differ in certain structural, physiological and biochemical aspects. However, it is not clearly known whether the functional differences between the two genders originate from these structural or biochemical differences. This sexual dimorphism in the structures and functions of the brain, and gender identity and orientation are thought to result, to a great extent, from the type and the level of the gonadal steroids which the brain is exposed to in a critical period of the embrional development. In this paper, the functional and structural differences of the brain between the male and female genders will be reviewed, and the embriological and evolutionary explanations will be discussed.
Anahtar Kelime: Sexual Behavior Female Male Brain Gender Identity

Konular: Kadın Araştırmaları
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1. Graziottin A. Similarities and differences between female and male sexual functions and dysfunctions. JMHG 2004; 1: 71-76
  • 2. Malatesta CZ, Haviland JM. Learning display rules: the socialization of emotion expression in infancy. Child Dev 1982; 53: 991-1003
  • 3. Pease B, Pease A. Why Men don’t Listen and Women can’t Read Maps. Broadway Books, New York, 2000
  • 4. Besson M, Magne C, Schön D. Emotional prosody: sex differences in sensitivity to speech melody. Trends Cog Sci 2002; 6: 405-407
  • 5. Baron-Cohen S. The Essential Difference. Male and Female Brains and the Truth about Autism. Basic Books, New York, 2003
  • 6. Schirmer A, Zysset S, Kotz SA, von Cramon DY. Gender differences in the activation of inferior frontal cortex during emotional speech perception. Neuroimage 2004; 21: 1114-1123
  • 7. Schirmer A, Kotz SA. ERP evidence for a sex-specific Stroop effect in emotional speech. J Cogn Neurosci 2003; 15: 1135-1148
  • 8. Canlı T, Sivers H, Whitfield SL, Gotlib IH, Gabrieli JD. Amygdala response to happy faces as a function of extraversion. Science 2002; 296: 2191
  • 9. Wager TD, Phan KL, Liberzon I, Taylor SF. Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging. Neuroimage 2003; 19: 513-531
  • 10. Bradley MM, Codispoti M, Sabatinelli D, Lang PJ. Emotion and motivation II: sex differences in picture processing. Emotion 2001; 1: 300-319
  • 11. Pogun S. Sex differences in brain and behavior: emphasis on nicotine, nitric oxide and place learning. Int J Psychophysiol 2001; 42: 195-208
  • 12. Rahman Q, Wilson GD, Abrahams S. Biosocial factors, sexual orientation and neurocognitive functioning. Psychoneuroendocrinology 2004; 29: 867-881
  • 13. Naliboff BD, Berman S, Chang L, Derbyshire SW, Suyenobu B, Vogt BA, Mandelkern M, Mayer EA. Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology 2003; 124: 1738-1747
  • 14. Josse G, Tzourio-Mazoyer N. Hemispheric specialization for language. Brain Res Rev 2004; 44: 1-12
  • 15. Walla P, Hufnagl B, Lindinger G, Deecke L, Lang W. Physiological evidence of gender differences in word recognition: a magnetoencephalographic (MEG) study. Cog Brain Res 2001; 12: 49-54
  • 16. Sommer IE, Aleman A, Bouma A, Kahn RS. Do women really have more bilateral language representation than men? A meta-analysis of functional imaging studies. Brain 2004; 127: 1845-1852
  • 17. Weiss EM, Siedentopf C, Hofer A, Deisenhammer EA, Hoptman MJ, Kremser C, Golaszewski S, Felber S, Fleischhacker WW, Delazer M. Brain activation pattern during a verbal fluency test in healthy male and female volunteers: a functional magnetic resonance imaging study. Neurosci Lett 2003a; 352: 191-194
  • 18. Seidman SN. Testosterone deficiency and mood in aging men: Pathogenic and therapeutic interactions. World J Biol Psychiatry 2003; 4: 14-20
  • 19. Jordan K, Wustenberg T, Heinze HJ, Peters M, Jancke L. Women and men exhibit different cortical activation patterns during mental rotation tasks. Neuropsychologia 2002; 40: 2397-2408
  • 20. Weiss E, Siedentopf CM, Hofer A, Deisenhammer EA, Hoptman MJ, Kremser C, Golaszewski S, Felber S, Fleischhacker WW, Delazer M. Sex differences in brain activation pattern during a visuospatial cognitive task: a functional magnetic resonance imaging study in healthy volunteers. Neurosci Lett 2003b; 344: 169-172
  • 21. Njemanze PC. Cerebral lateralization in random letter task in the visual modality: a transcranial Doppler study. Brain Lang 1996; 53: 315-325
  • 22. Kimura D. Sex, sexual orientation and sex hormones influence human cognitive function. Curr Opin Neurobiol 1996; 6: 259-263
  • 23. Cahill L. Sex- and hemisphere-related influences on the neurobiology of emotionally influenced memory. Prog Neuro- Psychopharmacol Biol Psychiatry 2003; 27: 1235-1241
  • 24. Breslau N, Davis GC, Andreski P, Peterson EL, Schultz LR. Sex differences in posttraumatic stress disorder. Arch Gen Psychiatry 1997; 54: 1044-1048
  • 25. Drevets WC, Price JL, Bardgett ME, Reich T, Todd RD, Raichle ME. Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels. Pharmacol Biochem Behav 2002; 71: 431-447
  • 26. Pratt MW, Golding G, Hunter W, Norris J. From inquiry to judgment: age and sex differences in patterns of adult moral thinking and information-seeking. Int J Aging Hum Dev 1988; 27: 109-124
  • 27. Kivlighan KT, Granger DA, Booth A. Gender differences in testosterone and cortisol response to competition. Psychoneuroendocrinology 2005; 30: 58-71
  • 28. Greene AR, Dixon W. The role of reproductive hormones in maintaining cognition. Obstet Gynecol Clin North Am 2002; 29: 437-453
  • 29. Sherwin BB. Hormones, mood, and cognitive functioning in postmenopausal women. Obstet Gynecol 1996; 87: 20-26
  • 30. Steiner M, Dunn E, Born L. Hormones and mood: from menarche to menopause and beyond. J Affect Disord 2003; 74: 67-83
  • 31. Christiansen K, Knussmann R. Sex hormones and cognitive functioning in men. Neuropsychobiology 1987; 18: 27-36
  • 32. Wolf OT, Kirschbaum C. Endogenous estradiol and testosterone levels are associated with cognitive performance in older women and men. Horm Behav 2002; 41: 259-266
  • 33. Moffat SD, Zonderman AB, Metter EJ, Blackman MR, Harman SM, Resnick SM. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab 2002; 87: 5001-5007
  • 34. Kenny AM, Bellantonio S, Gruman CA, Acosta RD, Prestwood KM. Effects of transdermal testosterone on cognitive function and health perception in older men with low bioavailable testosterone levels. J Gerontol Biol Sci Med Sci 2002; 57: 321-325
  • 35. Cherrier MM, Asthana S, Plymate S, Baker L, Matsumoto AM, Peskind E, Raskind MA, Brodkin K, Bremner W, Petrova A, LaTendresse S, Craft S. Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology 2001; 57: 80-88
  • 36. Frye CA, Edinger KL, Seliga AM, Wawrzycki JM. 5alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology 2004; 29: 1019-1027
  • 37. Kılıç C, Eşel E. Stres tepkisi süreci. Klinik Psikofarmakoloji Bülteni, 2002; 12: 41-48
  • 38. Shors TJ, Chua C, Falduto J. Sex differences and opposite effects of stress on dendritic spine density in the male versus female hippocampus. J Neurosci 2001; 21: 6292-6297
  • 39. Handa RJ, Burgess LH, Kerr JE, O'Keefe JA. Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitaryadrenal axis. Horm Behav 1994; 28: 464- 476
  • 40. Williams TD, Carter DA, Lightman SL. Sexual dimorphism in the posterior pituitary response to stress in the rat. Endocrinology 1985; 116: 738-740
  • 41. Galea LA, McEwen BS, Tanapat P, Deak T, Spencer RL, Dhabhar FS. Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress. Neuroscience 1997; 81: 689-697
  • 42. Rivier C. Gender, sex steroids, corticotropin-releasing factor, nitric oxide, and the HPA response to stress. Pharmacol Biochem Behav 1999; 64: 739-751
  • 43. Otte C, Hart S, Neylan TC, Marmar CR, Yaffe K, Mohr DC. A metaanalysis of cortisol response to challenge in human aging: importance of gender. Psychoneuroendocrinology 2005; 30: 80-91
  • 44. Grumbach MM. To an understanding of the biology of sex and gender differences: “an idea whose time has come”. JMHG 2004; 1: 12-19
  • 45. Yoshimura S, Sakamoto S, Kudo H, Sassa S, Kumai A, Okamoto R. Sex-differences in adrenocortical responsiveness during development in rats. Steroids 2003; 68: 439-445
  • 46. Kudielka BM, Buske-Kirschbaum A, Hellhammer DH, Kirschbaum C. HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender. Psychoneuroendocrinology 2004; 29: 83-98
  • 47. McCormick CM, Furey BF, Child M, Sawyer MJ, Donohue SM. Neonatal sex hormones have 'organizational' effects on the hypothalamic- pituitary-adrenal axis of male rats. Brain Res Dev Brain Res 1998; 105: 295-307
  • 48. Spinedi E, Salas M, Chisari A, Perone M, Carino M, Gaillard RC. Sex differences in the hypothalamo-pituitary-adrenal axis response to inflammatory and neuroendocrine stressors. Evidence for a pituitary defect in the autoimmune disease-susceptible female Lewis rat. Neuroendocrinology 1994; 60: 609-617
  • 49. Bowman RE, Beck KD, Luine VN. Chronic stress effects on memory: sex differences in performance and monoaminergic activity. Horm Behav 2003; 43: 48-59
  • 50. Shansky RM, Glavis-Bloom C, Lerman D, McRae P, Benson C, Miller K, Cosand L, Horvath TL, Arnsten AF. Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction. Mol Psychiatry 2004; 9: 531-538
  • 51. Kitraki E, Kremmyda O, Youlatos D, Alexis MN, Kittas C. Genderdependent alterations in corticosteroid receptor status and spatial performance following 21 days of restraint stress. Neuroscience 2004; 125: 47-55
  • 52. Cloitre M, Yonkers KA, Pearlstein T, Altemus M, Davidson KW, Pigott TA, Shear MK, Pine D, Ross J, Howell H, Brogan K, Rieckmann N, Clemow L. Women and anxiety disorders: implications for diagnosis and treatment. CNS Spectr 2004; 9 (Suppl 8):1-16
  • 53. Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP, Kim DM. The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev 2003; 27: 33-44
  • 54. Rakic P, Bourgeois JP, Eckenhoff MF, Zecevic N, Goldman-Rakic PS. Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex. Science 1986; 232: 232-235
  • 55. Meijer A. Child psychiatric sequelae of maternal war stress. Acta Psychiatr Scand 1985; 72: 505-511
  • 56. Weinstock M. Does prenatal stress impair coping and regulation of hypothalamic-pituitary-adrenal axis? Neurosci Biobehav Rev 1997; 21: 1-10
  • 57. Gue M, Bravard A, Meunier J, Veyrier R, Gaillet S, Recasens M, Maurice T. Sex differences in learning deficits induced by prenatal stress in juvenile rats. Behav Brain Res 2004; 150: 149-157
  • 58. Schmitz C, Rhodes ME, Bludau M, Kaplan S, Ong P, Ueffing I, Vehoff J, Korr H, Frye CA. Depression: reduced number of granule cells in the hippocampus of female, but not male, rats due to prenatal restraint stress. Mol Psychiatry 2002; 7: 810-813
  • 59. Sullivan PF, Wilson DA, Mulder RT, Joyce PR. The hypothalamicpituitary- thyroid axis in major depression. Acta Psychiatr Scand 1997 ; 95 : 370-378
  • 60. Esel E, Kartalci S, Tutus A, Turan T, Sofuoglu S. Effects of antidepressant treatment on thyrotropin-releasing hormone stimulation, growth hormone response to L-DOPA, and dexamethasone suppression tests in major depressive patients. Prog Neuro- Psychopharmacol & Biol Psychiat 2004a; 28: 303-309
  • 61. Esel E, Kilic C, Kula M, Basturk M, Ozsoy S, Turan T, Keles S, Sofuoglu S. Effects of electroconvulsive therapy on the Thyrotropin- Releasing Hormone Test in patients with depression. J ECT 2004b; 20: 248-253
  • 62. Putignano P, Brunani A, Dubini A, Bertolini M, Pasquali R, Cavagnini F. Effect of small doses of dexamethasone on plasma leptin levels in normal and obese subjects: a dose-response study. J Endocrinol Invest 2003; 26: 111-116
  • 63. Esel E, Özsoy SD, Tutus A, Sofuoğlu S, Bayram F, Kartalcı S, Kökbudak Z, Kula M. Effects of antidepressant treatment and of gender on serum leptin levels in patients with major depression. Prog Neuro-psychopharmacol Biol Psychiatry 2005 (yayıma kabul edildi).
  • 64. Levine SB. The nature of sexual desire: a clinician's perspective. Arch Sex Behav 2003; 32: 279-285
  • 65. Turna B, Apaydın E, Semerci B, Altay B, Cikili N, Nazlı O. Women with low libido: correlation of decreased androgen levels with female sexual function index. Int J Impot Res 2004
  • 66. Reeves H, de Rosnay J, Coppens Y, Simmonet D. Dünya’nın En Güzel Tarihi (Çev: İsmet Birkan), Türkiye İş Bankası Kültür Yayınları, İstanbul, 2003
  • 67. Anderson-Hunt M, Dennerstein L. Oxytocin and female sexuality. Gynecol Obstet Invest 1995; 40: 217-221
  • 68. Both S, Everaerd W, Laan E, Gooren L. Effect of a single dose of levodopa on sexual response in men and women. Neuropsychopharmacology 2005; 30: 173-183
  • 69. Kafka MP, Hennen J. Hypersexual desire in males: are males with paraphilias different from males with paraphilia-related disorders? Sex Abuse 2003; 15: 307-321
  • 70. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999;281: 537-544
  • 71. Simmonet D, Courtin J, Veyne P, Le Goff J, Sole J, Ozouf M, Corbin A, Sohn A-M, Bruckner P, Ferney A. Aşkın En Güzel Tarihi (Çev: Saadet Özen), Türkiye İş Bankası Kültür Yayınları, İstanbul, 2003
  • 72. Wilson GD. Gender difference in sexual fantasy: an evolutionary analysis. Person Individ Diff 1997; 22: 27-31
  • 73. Porges SW. Love: an emergent property of the mammalian autonomic nervous system. Psychoneuroendocrinology 1998; 23: 837-861
  • 74. Hennessy MB. Hypothalamic-pituitary-adrenal responses to brief social separation. Neurosci Biobehav Rev 1997; 21: 11-29
  • 75. Larsen CS. Equality for the sexes in human evolition? Early hominid sexual dimorphism and implications for mating systems and social behavior. Proc Natl Acad Sci U S A 2003; 100: 9103-9104
  • 76. Young LJ, Lim MM, Gingrich B. Cellular mechanisms of social attachment. Horm Behav 2001; 40: 133-138
  • 77. Carter CS. Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology 1998; 23: 779-818
  • 78. Eşel E. Depresyondaki nöroendokrinolojik bulgular. Klinik Psikiyatri Dergisi 2002, Ek 4, 35-50
  • 79. Engelmann M, Wotjak CT, Neumann I, Ludwig M, Landgraf R. Behavioral consequences of intracerebral vasopressin and oxytocin: focus on learning and memory. Neurosci Biobehav Rev 1996; 20: 341-358
  • 80. Insel TR. Is social attachment an addictive disorder ? Physiol Behav 2003; 79: 351-357
  • 81. Insel TR, Fernald RD. How the brain processes social information: searching for the social brain. Annu Rev Neurosci 2004; 27: 697-722
  • 82. Leckman JF, Herman AE. Maternal behavior and developmental psychopathology. Biol Psychiatry 2002; 51: 27-43.
  • 83. De Vries GJ, Boyle PA. Double duty for sex differences in the brain. Behav Brain Res 1998; 92: 205-213
  • 84. Fisher H. Why We Love: The Nature and Chemistry of Romantic Love. Henry Holt Company, New York, USA, 2004
  • 85. Arnow BA, Desmond JE, Banner LL, Glover GH, Solomon A, Polan ML, Lue TF, Atlas SW. Brain activation and sexual arousal in healthy, heterosexual males. Brain 2002; 125: 1014-1023
  • 86. Marazziti D, Canale D. Hormonal changes when falling in love. Psychoneuroendocrinology 2004; 29: 931-936
  • 87. Roselli CE, Larkin K, Schrunk JM, Stormshak F. Sexual partner preference, hypothalamic morphology and aromatase in rams. Physiol Behav 2004; 83: 233-245
  • 88. Rahman Q, Wilson GD. Born gay? The psychobiology of human sexual orientation. Pers Individ Dif 2003; 34: 1337-1382
  • 89. Brand T, Kroonen J, Mos J, Slob AK. Adult partner preference and sexual behavior of male rats affected by perinatal endocrine manipulations. Horm Behav 1991; 25: 323-341
  • 90. Cooke B, Hegstrom CD, Villeneuve LS, Breedlove SM. Sexual differentiation of the vertebrate brain: principles and mechanisms. Front Neuroendocrinol 1998; 19: 323-362
  • 91. Byne W, Lasco MS, Kemether E, Shinwari A, Edgar MA, Morgello S, Jones LB, Tobet S. The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and density. Brain Res 2000; 856: 254-258
  • 92. Bakker J, van Ophemert J, Slob AK. Organization of partner preference and sexual behavior and its nocturnal rhythmicity in male rats. Behav Neurosci 1993; 107: 1049-1058
  • 93. Houtsmuller EJ, Brand T, de Jonge FH, Joosten RN, van de Poll NE, Slob AK. SDN-POA volume, sexual behavior, and partner preference of male rats affected by perinatal treatment with ATD. Physiol Behav 1994; 56: 535-541
  • 94. Perkins A, Fitzgerald JA, Moss GE. A comparison of LH secretion and brain estradiol receptors in heterosexual and homosexual rams and female sheep. Horm Behav 1995; 29: 31-41
  • 95. Bailey JM. Homosexuality and mental illness. Arch Gen Psychiatry 1999; 56: 883-884
  • 96. Turan MT, Eşel E, Dündar M, Candemir Z, Baştürk M, Sofuoğlu S, Özkul Y. Female-to-male transsexual with 47,XXX karyotype: a case report. Biol Psychiatry 2000; 48: 1116- 1117
  • 97. Kessler RC. Epidemiology of women and depression. J Affect Disord 2003; 74: 5-13
  • 98. Goodwin RD, Gotlib IH. Gender differences in depression: the role of personality factors. Psychiatry Res 2004; 126: 135-142
  • 99. Nishizawa S, Benkelfat C, Young SN, Leyton M, Mzengeza S, de Montigny C, Blier P, Diksic M. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A 1997; 94: 5308-5313
  • 100.Li Q, Holmes A, Ma L, Van de Kar LD, Garcia F, Murphy DL. Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences. J Neurosci 2004; 24: 10868-10877
  • 101. Joffe H, Cohen LS. Estrogen, serotonin, and mood disturbance: where is the therapeutic bridge? Biol Psychiatry 1998; 44: 798-811
  • 102.Schmidt PJ, Neiman L, Danaceau MB, Tobin MB, Roca CA, Murphy JH, Rubinow DR. Estrogen replacement in perimenopause-related depression: a preliminary report. Am J Obstet Gynecol 2000; 183: 414-420
  • 103.Saletu B, Brandstatter N, Metka M, Stamenkovic M, Anderer P, Semlitsch HV, Heytmanek G, Huber J, Grunberger J, Linzmayer L, Kurz C, Decker K, Binder G, Knogler W, Koll B. Hormonal, syndromal and EEG mapping studies in menopausal syndrome patients with and without depression as compared with controls. Maturitas 1996; 23: 91-105
  • 104.Drevets WC. Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr Opin Neurobiol 2001; 11: 240-249
  • 105.Sobansky T, Wagner G, Sofianos G, Straube E, Sauer H. Genderrelated differences of brain function in major depression – an fMRI study based on a “perceptual organization” paradigm. 17th ECNP Congress 2004,October 9-13, Stockholm, Sweden
  • 106.Anderson SL, Dumont NL, Teicher MH. Developmental differences in dopamine synthesis inhibition by (+/-)-7-OH-DPAT. Naunyn Schmiedebergs Arch Pharmacol 1997; 356: 173-181
  • 107. Dubb A, Gur R, Avants B, Gee J. Characterization of sexual dimorphism in the human corpus callosum. Neuroimage 2003; 20: 512-519
  • 108.Hwang SJ, Ji EK, Lee EK, Kim YM, Shin da Y, Cheon YH, Rhyu IJ. Gender differences in the corpus callosum of neonates. Neuroreport 2004; 15: 1029-1032
  • 109. Adinoff B, Devous MD Sr, Best SE, Chandler P, Alexander D, Payne K, Harris TS, Williams MJ. Gender differences in limbic responsiveness, by SPECT, following a pharmacologic challenge in healthy subjects. Neuroimage 2003; 18: 697-706
  • 110. George MS, Ketter TA, Parekh PI, Herscovitch P, Post RM. Gender differences in regional cerebral blood flow during transient selfinduced sadness or happiness. Biol Psychiatry 1996; 40: 859-871
  • 111. Sullivan EV, Rosenbloom M, Serventi KL, Pfefferbaum A. Effects of age and sex on volumes of the thalamus, pons, and cortex. Neurobiol Aging 2004; 25: 185-192
  • 112. Giedd JN, Castellanos FX, Rajapakse JC, Vaituzis AC, Rapoport JL. Sexual dimorphism of the developing human brain. Prog Neuro- Psychopharmacol Biol Psychiatry 1997; 21: 1185-1201
  • 113. Segovia S, Guillamon A, del Cerro MCR, Ortega E, Perez-Laso C, Rodriguez-Zafra M, Beyer C. The development of brain sex differences: a multisignaling process. Behav Brain Res 1999; 105: 69-80
  • 114. Mizukami S, Nishizuka M, Arai Y. Sexual difference in nuclear volume and its ontogeny in the rat amygdala. Exp Neurol 1983; 79: 569-575
  • 115. Reed TE, Vernon PA, Johnson AM. Sex difference in brain nerve conduction velocity in normal humans. Neuropsychologia 2004; 42: 1709-1714
  • 116. Penotti M, Sironi L, Miglierina L, Farina M, Barletta L, Gabrielli L, Vignali M. The effect of tamoxifen and transdermal 17beta estradiol on cerebral arterial vessels: a randomized controlled study. Am J Obstet Gynecol 1998; 178: 801-805
  • 117. Laakso A, Vilkman H, Bergman J, Haaparanta M, Solin O, Syvalahti E, Salokangas RK, Hietala J. Sex differences in striatal presynaptic dopamine synthesis capacity in healthy subjects. Biol Psychiatry 2002 ; 52: 759-763
  • 118. Becker JB. Gender differences in dopaminergic function in striatum and nucleus accumbens. Pharmacol Biochem Behav 1999; 64: 803-812
  • 119. Rhodes ME, Rubin RT. Functional sex differences (‘sexual diergism’) of central nervous system cholinergic systems, vasopressin, and hypothalamic-pituitary-adrenal axis in mammals: a selective review. Brain Res Rev 1999; 30: 135-152
  • 120. Avissar S, Egozi Y, Sokolovsky M. Biochemical characterization and sex dimorphism of muscarinic receptors in rat adenohypophysis. Neuroendocrinology 1981; 32: 303-309
  • 121. Arnold AP, Burgoyne PS. Are XX and XY brain cells intrinsically different? Trends Endocrinol Metab 2004; 15: 6-11
  • 122.McCarthy MM, Auger AP, Perrot-Sinal TS. Getting excited about GABA and sex differences in the brain. Trends Neurosci 2002; 25: 307-312
  • 123. Obrietan K, van den Pol AN. GABA neurotransmission in the hypothalamus: developmental reversal from Ca2+ elevating to depressing. J Neurosci 1995;15: 5065-5077.
  • 124. Bach F, Flugge G, Wuttke W. GABAergic influence on the development of the sexually dimorphic nucleus of male and female rats. Brain Res 1992; 573: 341-344
  • 125.Rodriguez-Zafra M, De Blas MR, Perez-Laso C, Cales JM, Guillamon A, Segovia S. Effects of perinatal diazepam exposure on the sexually dimorphic rat locus coeruleus. Neurotoxicol Teratol 1993; 15: 139-144
  • 126. Collado P, Valencia A, Del Abril A, Rodriguez-Zafra M, Perez-Laso C, Segovia S, Guillamon A. Effects of estradiol on the development of sexual dimorphism in the bed nucleus of the accessory olfactory tract in the rat. Brain Res Dev Brain Res 1993; 75: 285-287
  • 127. Kartalc› fi, Eflel E. Nörosteroidler: psikofarmakolojik ve davran›flsal etkileri. Klinik Psikofarmakoloji Bülteni 2004; 14: 38-49
  • 128. Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, Virchow JC. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 2005; 26: 115-123
APA Eşel E (2005). Kadın ve erkek beyninin farklılıkları. , 138 - 152.
Chicago Eşel Ertuğrul Kadın ve erkek beyninin farklılıkları. (2005): 138 - 152.
MLA Eşel Ertuğrul Kadın ve erkek beyninin farklılıkları. , 2005, ss.138 - 152.
AMA Eşel E Kadın ve erkek beyninin farklılıkları. . 2005; 138 - 152.
Vancouver Eşel E Kadın ve erkek beyninin farklılıkları. . 2005; 138 - 152.
IEEE Eşel E "Kadın ve erkek beyninin farklılıkları." , ss.138 - 152, 2005.
ISNAD Eşel, Ertuğrul. "Kadın ve erkek beyninin farklılıkları". (2005), 138-152.
APA Eşel E (2005). Kadın ve erkek beyninin farklılıkları. Klinik Psikofarmakoloji Bülteni, 15(3), 138 - 152.
Chicago Eşel Ertuğrul Kadın ve erkek beyninin farklılıkları. Klinik Psikofarmakoloji Bülteni 15, no.3 (2005): 138 - 152.
MLA Eşel Ertuğrul Kadın ve erkek beyninin farklılıkları. Klinik Psikofarmakoloji Bülteni, vol.15, no.3, 2005, ss.138 - 152.
AMA Eşel E Kadın ve erkek beyninin farklılıkları. Klinik Psikofarmakoloji Bülteni. 2005; 15(3): 138 - 152.
Vancouver Eşel E Kadın ve erkek beyninin farklılıkları. Klinik Psikofarmakoloji Bülteni. 2005; 15(3): 138 - 152.
IEEE Eşel E "Kadın ve erkek beyninin farklılıkları." Klinik Psikofarmakoloji Bülteni, 15, ss.138 - 152, 2005.
ISNAD Eşel, Ertuğrul. "Kadın ve erkek beyninin farklılıkları". Klinik Psikofarmakoloji Bülteni 15/3 (2005), 138-152.