Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması

Münire Özlem ÇEVİK (TOBB Ekonomi ve Teknoloji Üniversitesi, Ankara, Türkiye)
8 3

Proje Grubu: SOBAG Sayfa Sayısı: 89 Proje No: 114K826 Proje Bitiş Tarihi: 01.10.2018 Metin Dili: Türkçe İndeks Tarihi: 06-09-2019

Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması

Öz:
Bu projenin amacı, dopaminerjik iletinin dikkat ve dikkat bozukluklarına nasıl aracılık ettiğini araştırmaktır. Meyve sineği Drosophila melanogaster kullanılarak yapılan translasyonel çalışmalarda, kendi geliştirmiş olduğumuz bir davranış testi uygulanmış, ve birbirini karşılıklı olarak dışlayan refleksler tetikleyen uyarıcıların varlığında dikkatin duyular arasında nasıl yönlendirildiği saptanmıştır. Daha sonra, dopamin tip 1 reseptör-1 mutasyonunun (Dop1R1) dikkatin uyarıcılar veya fizyolojik durumun belirlediği öncelikler tarafından yönlendirilmesi üzerindeki etkileri test edilmiştir. Sonuçlarımız, Dop1R1 mutasyonunun yukarıdan-aşağı dikkat süreçlerini bozarak davranışı daha uyarıcılara-bağlı hale getirdiğini, ve tepkiler arasında esnek geçişleri azalttığını göstermektedir. Dop1R1 mutasyonunun hedefli olarak böcek beynindeki en önemli heteromodal duyu entegrasyon alanlarından biri olan mantarsı yapılarda kurtarılması, çift-fazlı tepki örüntüsünün geri kazanılması için yeterli olmuştur. Dop1R1 mutasyonu, genetik arka planla etkileşim içerisinde hem hipoaktif hem de hiperaktif fenotiplerin ortaya çıkmasına sebep olmuştur. Dolayısıyla, proje sonuçları, meyve sineği Drosophila melanogaster Dop1R1 mutantlarının dikkat bozukluğu sendromları için uygun bir translasyonel hayvan model oluşturduğunu önermektedir.
Anahtar Kelime: dopamine dikkat Drosophila melanogaster

Konular: Psikoloji
Erişim Türü: Erişime Açık
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APA ÇEVİK M (2018). Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. , 0 - 89.
Chicago ÇEVİK Münire Özlem Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. (2018): 0 - 89.
MLA ÇEVİK Münire Özlem Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. , 2018, ss.0 - 89.
AMA ÇEVİK M Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. . 2018; 0 - 89.
Vancouver ÇEVİK M Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. . 2018; 0 - 89.
IEEE ÇEVİK M "Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması." , ss.0 - 89, 2018.
ISNAD ÇEVİK, Münire Özlem. "Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması". (2018), 0-89.
APA ÇEVİK M (2018). Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. , 0 - 89.
Chicago ÇEVİK Münire Özlem Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. (2018): 0 - 89.
MLA ÇEVİK Münire Özlem Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. , 2018, ss.0 - 89.
AMA ÇEVİK M Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. . 2018; 0 - 89.
Vancouver ÇEVİK M Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması. . 2018; 0 - 89.
IEEE ÇEVİK M "Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması." , ss.0 - 89, 2018.
ISNAD ÇEVİK, Münire Özlem. "Meyve sineği Drosophila melanogaster’da dikkatin nöral temellerinin araştırılması". (2018), 0-89.
Sayfa Oluşturulma Tarihi
24-04-2024 1:32

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