Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi

Mustafa KARAMAN (KONYA TEKNİK ÜNİVERSİTESİ)
Türk Hatice DAĞI, (KONYA TEKNİK ÜNİVERSİTESİ)
Agah Bahadır ÖZTÜRK (KONYA TEKNİK ÜNİVERSİTESİ)
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Proje Grubu: MAG Sayfa Sayısı: 66 Proje No: 216M448 Proje Bitiş Tarihi: 15.10.2019 Metin Dili: Türkçe İndeks Tarihi: 29-03-2021

Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi

Öz:
Bu çalısmada kuaterner amonyum fonksiyonel grubu içeren polimerik ince filmler baslatıcılı kimyasal buhar biriktirme (iCVD) teknigi ile farklı alttaslar üzerinde sentezlenmistir. iCVD tekniginde baslatıcı olarak ter bütil peroksit kullanarak poli(dietilaminoetil metakrilat) (PDEAEMA) homopolimer ve poli(dietilaminoetil metakrilat-ko-vinilbenzil klorür) (P (DEAEMAVBC)) kopolimer kaplamaları yapılmıstır. FTIR ve XPS analizleri yapılarak, reaktör girisindeki monomer besleme akıs hızı oranlarının degisimi ile kaplanan filmlerin kimyasal yapılarının ayarlanabildigi gösterilmistir. Kopolimer içerisindeki DEAEMA monomerinden kanaklanan tersiyer amin fonksiyonel grubu antibakteriyel aktivite için gereklidir. PDEAEMA homopolimeri oksijen plazma muamelesi ile kuru bir sekilde protonlanabilmistir. Diger yandan P(DEAEMA-VBC) kopolimeri ilave bir protonlama asamasına ihtiyaç duymamıstır çünkü polimerin tersiyer amin grubu, VBC yapısındaki klor fonksiyonelligi tarafından kolayca protonlanabilmektedir. Hem homo hem de ko-polimerler, kaplanan polimerdeki protonlanmıs azot atomlarının yogunluguna baglı olarak cam, PET levha ve kumas olmak üzere üç farklı alttas üzerinde yüksek antibakteriyel aktivite göstermistir Scotch bantı soyma testi uygulanmıs ve neticesinde kopolimer filmlerin yapısma ve dayanıklılıgının homopolimer filme göre üstün oldugu dogrulanmıstır. En dayanıklı olarak belirlenen kopolimer film gram negatif ve gram pozitif bakterilere karsı çok yüksek log eksiltme degeri göstermistir. Hücre canlılıgı analizine neticesinde bu çalısmada iCVD ile kaplanan antibakteriyel filmlerin toksik olmadıgı kanıtlanmıstır. Çalısmanın ikinci bölümünde bir çekirge türü olan Bradyporus (Callimenus) göçmeninin yumurta kabugundan esinlenerek biyobenzetim ile antibakteriyel yüzey tasarımı gerçeklestirilmistir. Bu amaçla, yumusak litografi yöntemiyle yumurta kabugu yapılarına benzer nano/mikro yapılı esnek yüzeyler üretilmistir. Daha sonra, üretilen yüzey yapıları iCVD teknigi kullanılarak antibakteriyel ince film ile kaplanmıstır. Elde edilen kopyalar, bakteri popülasyonunda 7 log eksiltme degerine kadar ulasan antibakteriyel aktivite ve oldukça yüksek su iticilik göstermistir. Proje yaygınlastırma faaliyetleri kapsamında antibakteriyel.ktun.edu.tr web sitesi yayınlamıs olup, burada proje kapsamında hazırlanan Antibakteriyel Yüzeyler Durum Raporları yayınlanmıstır. Ayrıca, antibakteriyel yüzeylerin öneminin anlatıldıgı projede görev alan ögrenciler tarafından hazırlanan videolar Functional Surfaces youtube kanalında yayınlanmıstır. Proje kapsamında gerçeklestirilen çalıstaylara ait bilgi ve görseller ile; proje yaygınlastırma faaliyetlerine ait diger çalısmaların detayları da proje web sitesine eklenmistir.
Anahtar Kelime: biyobenzetim bradyporus (callimenus) gocmeni icvd polimer kuaterner amonyum antibakteriyel

Konular: Mühendislik, Kimya
Erişim Türü: Erişime Açık
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APA Karaman M, DAĞI T, ÖZTÜRK A (2019). Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. , 1 - 66.
Chicago Karaman Mustafa,DAĞI Türk Hatice,ÖZTÜRK AGAH BAHADIR Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. (2019): 1 - 66.
MLA Karaman Mustafa,DAĞI Türk Hatice,ÖZTÜRK AGAH BAHADIR Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. , 2019, ss.1 - 66.
AMA Karaman M,DAĞI T,ÖZTÜRK A Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. . 2019; 1 - 66.
Vancouver Karaman M,DAĞI T,ÖZTÜRK A Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. . 2019; 1 - 66.
IEEE Karaman M,DAĞI T,ÖZTÜRK A "Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi." , ss.1 - 66, 2019.
ISNAD Karaman, Mustafa vd. "Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi". (2019), 1-66.
APA Karaman M, DAĞI T, ÖZTÜRK A (2019). Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. , 1 - 66.
Chicago Karaman Mustafa,DAĞI Türk Hatice,ÖZTÜRK AGAH BAHADIR Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. (2019): 1 - 66.
MLA Karaman Mustafa,DAĞI Türk Hatice,ÖZTÜRK AGAH BAHADIR Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. , 2019, ss.1 - 66.
AMA Karaman M,DAĞI T,ÖZTÜRK A Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. . 2019; 1 - 66.
Vancouver Karaman M,DAĞI T,ÖZTÜRK A Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi. . 2019; 1 - 66.
IEEE Karaman M,DAĞI T,ÖZTÜRK A "Antibakteriyel Nanokaplama Teknolojilerinde Mükemmeliyet Için Ingiltere-Türkiye Isbirligi." , ss.1 - 66, 2019.
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