TY  - JOUR
TI  - The effects of pre-and postnatal Cd exposure on conduction velocity in sciatic nerve
AB  - The purpose of the study has been to investigate the effect of pre-and postnatal Cd exposure on conduction velocity of sciatic nerve. Pregnant Swiss albino rats were divided into three groups as control (C), cadmium (Cd) and non-cadmium (NCd) groups. Control animals received tap water while rats in Cd group received Cd as CdCl2 in their drinking water during the experimental period. The mothers of the NCd group were given Cd during their pregnancy but given tap water after birth. Twenty-two days after birth (postnatal day 22) the rats were separated from the mothers. The present study was performed on 80 rats which were divided into C, NCd, Cd1 and Cd2 groups, each in cluding 20 rats. Cd1 group received CdCl2 water for an additional 8 days. On postnatal day (PND) 30, conduction velocities and amplitudes of compound action potentials were determined from sciatic nerves of this group. The other rats were continued to be treated with Cd (Cd2 group) or tap water (C and NCd groups) for an additional 38 days. On PND, 60, the same measurements were made for these groups as mentioned above. The means of the peripheral conduction velocities decreased significanty in all the Cd-treated groups compared with control group. The mean of the compound action potential amplitudes was significantly decreased only in Cd2 group compared with control group.
AU  - ŞENTÜRK, Ümit Kemal
AU  - Agar, Aysel
AU  - Kilic, Derya
AU  - UYSAL, Nimet İzgüt
AU  - YARGIÇOĞLU, Piraye
PY  - 1998
JO  - Turkish Journal of Medical Sciences
VL  - 28
IS  - 1
SN  - 1300-0144
SP  - 47
EP  - 51
DB  - TRDizin
UR  - http://search/yayin/detay/6250
ER  -