Yıl: 2006 Cilt: 12 Sayı: 3 Sayfa Aralığı: 189 - 194 Metin Dili: Türkçe

The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study

Öz:
AMAÇ: Bu çalışmada hipotansif sıçan modelinde düşük doz dopamin infüzyonunun böbrek koruyucu etkisi araştırıldı. GEREÇ-YÖNTEM: Çalışmada kontrol, hipotansiyon, dopamin ve dopamin+hipotansiyon gruplarına ayrılan Wistar cinsi 40 sıçan kullanıldı. Hipotansiyon yaratmak için sodium nitroprussid infüzyonu kullanıldı ve iki saatlik çalışma süresince kan ve idrar örnekleri toplandı. BULGULAR: Hipotansiyon grubunda kan üre nitrojen düzeyinin çalışmanın birinci saatinde anlamlı derecede yükseldiği, fakat çalışma süresinin sonunda bu farkın kaybolduğu gözlendi. Dopamin infüzyonunun kreatinin ve potasyum klirensine etkisi gözlenmedi. Sadece dopamin verilen sıçanlarda natriürez gözlenmezken, dopamin verilen hipotansif sıçanlarda idrar sodyum atılımının anlamlı derecede arttığı saptandı. SONUÇ: Düşük doz dopamin infüzyonunun farmakolojik olarak oluşturulan hipotansiyonun erken safhasındaki kan üre nitrojen yükselmesine karşı engelleyici etki gösterdiği saptandı.
Anahtar Kelime: Kreatinin Böbrek Hayvan deneyleri Sıçan, Wistar Hipotansiyon Kan üre nitrojen Reseptörler, dopamin Dopamin

Hipotansif sıçan modelinde düşük doz dopamin infüzyonunun böbrek koruyucu etkisi: Deneysel çalışma

Öz:
BACKGROUND: The aim of this study was to investigate the effect of low-dose dopamine on markers of the renal functions in a rat model of hypotension. METHODS: Forty Wistar rats were divided into control, hypotension, dopamine, and hypotension+dopamine groups. Hypotension was achieved by sodium-nitroprusside infusion. Samples were drawn for analysis during the two-hour study period. RESULTS: Blood urea nitrogen levels were significantly increased in hypotension group during the early phase but this difference disappeared at the end of the second hour. Dopamine infusion had no effect on creatinine and potassium clearance. Despite the significance of improved sodium clearance in the hypotensive rats treated with dopamine, natriuresis did not occurred in the dopamine-only group. CONCLUSION: It can be stated that low dose dopamine infusion at a rate of 0.5 µg kg-1 min-1 has a short-term preventive action against the increase of blood urea nitrogen during the early phase of pharmacologically induced hypotension.
Anahtar Kelime: Animal Experimentation Creatinine Receptors, Dopamine Dopamine Hypotension Blood Urea Nitrogen Kidney Rats, Wistar

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA KAYA H, TUFAN H, ÖZDOĞAN M, ARSLAN G (2006). The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, 12(3), 189 - 194.
Chicago KAYA Hatice,TUFAN HALE,ÖZDOĞAN Mehmet,ARSLAN Gülnaz The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study. Ulusal Travma ve Acil Cerrahi Dergisi 12, no.3 (2006): 189 - 194.
MLA KAYA Hatice,TUFAN HALE,ÖZDOĞAN Mehmet,ARSLAN Gülnaz The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, vol.12, no.3, 2006, ss.189 - 194.
AMA KAYA H,TUFAN H,ÖZDOĞAN M,ARSLAN G The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study. Ulusal Travma ve Acil Cerrahi Dergisi. 2006; 12(3): 189 - 194.
Vancouver KAYA H,TUFAN H,ÖZDOĞAN M,ARSLAN G The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study. Ulusal Travma ve Acil Cerrahi Dergisi. 2006; 12(3): 189 - 194.
IEEE KAYA H,TUFAN H,ÖZDOĞAN M,ARSLAN G "The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study." Ulusal Travma ve Acil Cerrahi Dergisi, 12, ss.189 - 194, 2006.
ISNAD KAYA, Hatice vd. "The protective effect of low-dose dopamine on renal functions in hypotensive rats: an experimental study". Ulusal Travma ve Acil Cerrahi Dergisi 12/3 (2006), 189-194.