Endüstriyel nisin üretiminde etkili faktörler ve model sistemler

Ömer ŞİMŞEK, (Pamukkale Üniversitesi, Mühendislik Fakültesi, Denizli, Türkiye)
Ahmet Hilmi ÇON, (Pamukkale Üniversitesi, Mühendislik Fakültesi, Denizli, Türkiye)
Mustafa AKÇELİK (Ankara Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Ankara, Türkiye)
Mühendislik Bilimleri Dergisi
5 0
Yıl: 2007 Cilt: 13 Sayı: 1 Sayfa Aralığı: 57 - 67 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Endüstriyel nisin üretiminde etkili faktörler ve model sistemler

Öz:
Nisin tip I lantibiyotik grubuna dahil olan ve Lactococcus lactis'de tanımlanan ilk bakteriyosindir. Kültür ortamlarında yüksek miktarda nisin üretimi; fermentasyon ortamının kompozisyonu, pH, ortamda üretilen nisin konsantrasyonu ve en önemlisi hücrenin gelişimi ile ilişkilidir. Bu faktörler dikkate alınarak endüstriyel üretim amacıyla kesikli, yarı kesikli ve sürekli fermentasyon sistemleri geliştirilmiştir. Gıda koruyucusu olarak önemli potansiyele sahip olan nisinin daha verimli üretiminin sağlanması, hem endüstriyel açıdan ve hem de bu suşların starter kültür olarak kullanımı açısından önem taşımaktadır. Bu derlemede nisin üretimi üzerinde fermentasyon faktörlerinin etkileri belirtilerek kurulmuş model sistemler karşılaştırılmıştır.
Anahtar Kelime:

Effective factors and model systems in the industrial production of nisin

Öz:
Nisin is the first bacteriocin identified in Lactococcus lactis and belongs to type 1 lanthibiotic group. High nisin production in cultured media is related with the composition of fermentation medium, pH, produced nisin concentration and most importantly growth amount of cell. For industrial purpose, batch, fed-batch and continue fermentation systems were developed by regarding these factors. Maintaining efficient production of nisin having important potential at preservation of foods is important for both industrial production and using as starter culture. In this review the fermentation factors at nisin production were outlined and constructed model systems were compared
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Akçelik, O., Tukel, Ç., Özcengiz, G. and Akçelik, M. 2006. Characterization of Bacteriocins From Two Lactococcus lactis subsp. lactis Isolates. Mol Nutr Food Res. 50: 306-13.
  • Amiali, M. N., Lacroix, C. and Simard, R. E. 1998. High Nisin Z Production by Lactococcus lactis UL719 in Whey Permeate with Aeration. World J. Microbiol. And Biotechnol. 14: 887-894. Beasley, S. S. and Saris P. E. J. 2004. Nisin Producing Lactococcus lactis Strains Isolated From Human Milk. Appl. Environ. Microbiol. 70: 5051-5053.
  • Bertrand, N., Fliss, I. and Lacroix, C. 2001. High Nisin-Z Production During Repeated-cycle Batch Cultures in Supplemented Whey Permeate Using Immobilized Lactococcus lactis UL719. Inter. Dairy Journal. 11: 953-960.
  • Broughton, D. J. 1990. Nisin and Its Uses as a Food Preservative. Food Technology. 44: 100-117.
  • Chandrapati, S. and O'sullivan, D. J. 1999. Nisin Independent Induction of the nisA Promoter in Lactococcus lactis During Growth in Lactose or Galactose. FEMS Microbiol. Letters. 170: 191-198.
  • Chandrapati, S. and O'sullivan, D. J. 2002. Characterization of Promoter Regions Involved in Galactose and Nisin Mediated Induction of the nisA Gene Lactococcus lactis ATCC 11454. Molecular Microbiol. 2: 467-477.
  • Cheigh, C. I., Choi, H. J., Park, H., Kim, S., Kook, M., Kim, T., Hwang, J. and Pyun, Y. 2002. Influence of Growth Conditions on the Production of a Nisin-like Bacteriocin by Lactococcus lactis subsp. lactis A164 Isolated from Kimchi. J. Biotechnol. 95; 225-235.
  • Cheigh, C. I. and Pyun, Y. 2005. Nisin Biosynthesis and Its Properties. Biotechnol. Letters. 27; 1641-1648.
  • De Vusyt, L. and Vandamme, E. J. 1993. Influence of the Phosphorus and Nitrogen Source on Nisin Production in Lactococcus lactis subsp. lactis Batch Fermentations Using a Complex Medium. Appl. Microbiol. Biotechnol. 40: 17-22.
  • De Vuyst, L. 1995. Nutritional Factors Affecting Nisin Production by Lactococcus lactis subsp. lactis NIZO 22186 in a Synthetic Medium. J. Appl. Bacteriol. 78; 28-33.
  • De Vuyst, L. and Vandamme, E. J. 1992. Influence of the Carbon Source on Nisin Production in Lactococcus lactis subsp. lactis Batch Fermentations. J. General Microbiol. 138; 571-578.
  • Desjardins, P., Meghrous, J. and Lacroix, C. 2001. Effect of Aeration and Dilution Rate on Nisin Z Production During Continuous Fermentation with Free and Immobilizied Lactococcus lactis UL719 in Supplemented Whey Permeate. Inter. Dairy Journal. 11:943-951.
  • Dodd,H. M., Horn, N. and Gasson, M. J. 1990. Analysis of the Genetic Determinant for Production of the Peptide Antibiotic Nisin. J. General Microbiol. 136: 555-566.
  • Even, S., Lindley, N. D., Loublere, P., Cocaign-Bousquet, M. 2002. Dynamic Response of Catabolic Pathways to Autoacidification in Lactococcus lactis: Transcript Profilling and Stability in Relation to Metabolic and Energetic Constraints. Mol. Microbiol. 45: 1143-1152.
  • Gasson, M. J. 1984. Transfer of Sucrose Fermenting Ability,, Nisin Resistance and Nisin Production Into Straptococcus lactis 71. FEMS Microbiol. Letters. 21:7-10.
  • Gasson, M. J. 1990. In Vivo Genetic Systems in Lactic Acid Bacteria. FEMS Microbiol. Reviews. 87: 43-60.
  • Gonzales,C F. and Kunka, B. S. 1985. Transfer of Sucrose Fermenting Ability and Nisin Production Phenotypee Among Lactic streptococci. Appl. Environ. Microbiology.49: 627-633.
  • Guerra, N. P. and Pastrana, L. 2001. Enhanced Nisin and Pediocin Prodution on Whey Supplemented with Different Nitrogen Sources. Biotechnol. Letters. 23 : 609-612.
  • Guerra, R P. and Pastrana, L. 2002. Modelling the Influence of pH on the Kinetics of Both Nisin and Pediocin Production and Characterization of their Functional Properties. Process Biochemistry.37:1005-1015
  • Guerra, N. P. and Pastrana, L. C. 2003. Influence of pH Drop on Both Nisin and Pediocin Production by Lactococcus lactis and Pedlococcus acidilactici. Letters Appl. Microbiol. 37: 51-55.
  • Hul, J.S.V. and Gibbons W. R. 1997. Neutralization/recovery of Lactic Acid from Lactococcus lactis: Effects on Biomass, Lactic Acid and Nisin Production. World J. Microbiol. Biotechnol. 13: 527-532.
  • Kim, W. S., Hall R. J. and Dunn N. W. 1997. Host Specifity of Nisin Production by Lactococcus lactis. echnol. Letters, i9: 1235-1238.
  • Kim, W. S. 1997. Nisin Production by Lactococcus lactis Using two-phase Batch Culture. Letters Appl. Microbiol. 25: 169-171.
  • Kim, W. S., Hall R. I. and Dunn, N. W. 1998. Improving Nisin Production by Increasing Immunity/resistance Genes in the Producer Organisim Lactococcus lactis. Appl. Microbiol. Biotechnol. 50: 429-433.
  • Kim, W. S., Hall, R.J. and Dunn, N.W. 1997. The Effect of Nisin Concentration and Nutrient Depletion on Nisin Production of Lactococcus lactis. Appl. Microbiol. Biotechnol. 48: 449-453.
  • Klaenhammer, T. R. 1993. Genetics of Bacteriocins Produced by Lactic Acid Bacteria. FEMS Microbiol. Rev. 12: 39-85.
  • Leblanc, D. J., Crow, V. L. and Lee, L. N. 1980. Plasmid Mediated Carbohydrate Catabolic Enzymes Among Strains of Streptococcus lactis. In Plasmids and Transposons: Environmental Effects and Maintenace Mechanisms, pp. 31-41. Edited by C.Stuttard and K.R. Rozee. New York: Academic Press.
  • Li, C., Bai, J., Cai, Z. and Ouyang, F. 2002. Optimization of a Cultural Medium for Bacteriocin Production by Lactococcus lactis Using Response Surface Methodology. J. Biotechnol. 93; 27-34.
  • Liu, C., Liu, Y., Liao, W., Wen, Z. and Chen, S. 2003. Application of Statistically-based Experimental Designs for the Optimization of Nisin Production from Whey. Biotechnol. Letters. 25; 877-882.
  • Liu, X., Chung, Y-K. Yang S. T. and Yousef, A. E. 2005. Continuous Nisin Production in Laboratory Media and Whey Permeate by Immobilized Lactococcus lactis. Process Biochemistry. 40; 13-24.
  • Lv, W., Cong W. and Cai, Z. 2004a. Nisin Production by Lactococcus lactis subsp. lactis under Nutritional Limitation in Fed-batch Culture. Biotechnol. Letters. 26; 235-238.
  • Lv, W., Cong, W. and Cai, Z. 2004b. Improvement of Nisin Production in pH Feed-back Controlled, Fed-batch Culture by Lactococcus lactis subsp. lactis. Biotechnol. Letters. 26: 1713-5716.
  • Lv, W., Cong, W. and Cai, Z. 2005. Effect of Sucrose on Nisin Production in Batch and Fed-batch Culture by Lactococcus lactis. J. Chemical Technology and Biotechnol. 80: 511-514.
  • Matsusaki, H., Endo, N., Sonomoto, K. and Ishizaki, A. 1996. Lantibiotic Nisin Z Fermentative Production by Lactococcus lactis IO-1: Relationship Between Production of the Lantibiotic and Lactate and Cell Growth. Appl. Microbiol. Biotechnol. 45: 36-40.
  • Pongtharangkul, T. and Demirci, A. 2006.Evaluation of Culture Medium for Nisin Production in a Repeated-batch Biofilm Reactor. Biotechnol.Prog. 22: 217-224.
  • Oiao, M., Omaetxebarria, M. J., Ra, R., Oruetxebarria, I. and Saris, P. E. J. 1997. Isolation of a Lactococcus lactis Strain with High Resistance to Nisin and Increased Nisin Production. Biotechol. Letters. 19:199-202.
  • Qiao, M., Ye, S., Koponen, O., Ra, R., Usabiaga, M., Immonen, T., Saris, P. E. J. 1996. Regulation of the Nisin Operon in Lactococcus lactis N8. J. Appl. Bacteriol. 80: 626-614.
  • Ra, S. R., Qiao, M., Immonen, T., Pujana, I. and Saris, P. E. J. 1996. Genes Responsible for Nisin Synthesis, Regulation and Immunity from a Regulon of Two Operons and are Induced by Nisin in Lactococcus lactis N8. Microbiology. 142: 1281-1288.
  • Saris, P. E. J., Immonen, T., Reis, M., and Sahi, H. G. 1996. Immunity to Lanttibiotics. Antonie van Leeuwenhoek. 69: 151-159.
  • Scannell, A. G. M., Hill, C., Ross, R. P., Marx, S., Hartmeier, W. and Arendt, E. K. 2000. Continuous Prodution of Lacticin 3147 and Nisin Using Cells Immobilized in Calcium Alginate. J. Appl. Microbiol. 89: 573-579.
  • Shımuzu, H., Mizuguchi, T., Tanaka, E. and Shioya, S. 1999. Nisin Production by a Mixed -Culture System Consisting of Lactococcus lactis and Kluyveromyces marxianus. Appl. Environ. Microbiol. 65:3134-3141.
  • Siegumfeldt, H., Rechinger, K.B. and Jakobsen M. 2000. Dynamic Changes of Intracellular pH in Individual Lactic Acid Bacterium Cells Response to a Rapid Drop in Extracellular pH. Appl. Environ. Microbiol. 66: 2330-2335.
  • Sonomoto, K., Chinachoti, N., Endo, N. and Ishizaki, A. 2000. Biosynthetiç Production of Nisin Z by Immobilized Lactococcus lactis IO-1. J. Molecular Cat. B: Enzymatic. 10: 325-334 Steele, J.L. and McKay, L. L. 1986. Partial Characterization of the Genetic Basis for Sucrose Metabolism and Nisin Propduction in Streptococcus lactis. Appl. Environ. Microbiol. 64: 57-64.
  • Steen, M. T., Chung, Y. J. and Hansen, J. N. 1991. Characterization of the Nisin Gene as a Part of a Polycistronic Operon in the Chromosome of Lactococcus lactis ATCC 11454. Appl. Environ. Microbiol. 57: 1181-1188.
  • Takala, M. T., Koponen, O., Qiao, M. and Saris P.E.J. 2004. Lipid-free NisI: Intereaction with Nisin and Contribution to Nisin Immunity via Secretion. FEMS Microbiol. Letters. 237: 171-177.
  • Tolonen, M., Saris, P. E. J. and Siika-aho, M. 2004. Production of Nisin with Continuous Adsorption to Ambelite XAD-4 Resin Using Lactococcus lactis N8 and L. lactis LAC48. Appl. Microbiol. Biotechnol. 63: 659-665.
  • Vazquez, J.A. Cabo, M. L., Gonzalez, M. P. and Murado, M. A. 2004. The Role of Amino Acids in Nisin and Pediocin Production by Two Lactic Acid Bacteria a Factorial Study. Enzyme and Microbiol. Technol.. 34:319-325.
  • Wan, J., Hickey, W. and Conventry, M. J. 1995. Continuous Production of Bacteriocins, Brevicin, Nisin and Pediocin, Using Calcium Alginate-Immobilized Bacteria. J. Appl. Bacteriol. 79: 671-676.
  • Wardani, A. H., Egawa, S., Nagahisa, K., Shimizu, H. And Shioya, S. 2006. Computational Prediction of Impact of Rerouting the Carbon Flux in Metabolic Pathway on Cell Growth and Nisin Production by Lactococcus lactis. Biochemical Engineering Journal. 28: 220-230.
  • Yang, R., Johnson, M. C. and Ray, B. 1992. Novel Method to Extract Amounts of Bacteriocins from Lactic Acid Bacteria. Appl. Environ. Microbiol. 58: 3355-3359.
  • Yu, P. L., Dunn, N. W. and Kim, W. S. 2002. Lactate Removal by Anionic-exchange Resin Improves Nisin Production by Lactococcus lactis. Biotechnol. Letters. 24; 59-64.
APA ŞİMŞEK Ö, ÇON A, Akçelik M (2007). Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. , 57 - 67.
Chicago ŞİMŞEK Ömer,ÇON Ahmet Hilmi,Akçelik Mustafa Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. (2007): 57 - 67.
MLA ŞİMŞEK Ömer,ÇON Ahmet Hilmi,Akçelik Mustafa Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. , 2007, ss.57 - 67.
AMA ŞİMŞEK Ö,ÇON A,Akçelik M Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. . 2007; 57 - 67.
Vancouver ŞİMŞEK Ö,ÇON A,Akçelik M Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. . 2007; 57 - 67.
IEEE ŞİMŞEK Ö,ÇON A,Akçelik M "Endüstriyel nisin üretiminde etkili faktörler ve model sistemler." , ss.57 - 67, 2007.
ISNAD ŞİMŞEK, Ömer vd. "Endüstriyel nisin üretiminde etkili faktörler ve model sistemler". (2007), 57-67.
APA ŞİMŞEK Ö, ÇON A, Akçelik M (2007). Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. Mühendislik Bilimleri Dergisi, 13(1), 57 - 67.
Chicago ŞİMŞEK Ömer,ÇON Ahmet Hilmi,Akçelik Mustafa Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. Mühendislik Bilimleri Dergisi 13, no.1 (2007): 57 - 67.
MLA ŞİMŞEK Ömer,ÇON Ahmet Hilmi,Akçelik Mustafa Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. Mühendislik Bilimleri Dergisi, vol.13, no.1, 2007, ss.57 - 67.
AMA ŞİMŞEK Ö,ÇON A,Akçelik M Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. Mühendislik Bilimleri Dergisi. 2007; 13(1): 57 - 67.
Vancouver ŞİMŞEK Ö,ÇON A,Akçelik M Endüstriyel nisin üretiminde etkili faktörler ve model sistemler. Mühendislik Bilimleri Dergisi. 2007; 13(1): 57 - 67.
IEEE ŞİMŞEK Ö,ÇON A,Akçelik M "Endüstriyel nisin üretiminde etkili faktörler ve model sistemler." Mühendislik Bilimleri Dergisi, 13, ss.57 - 67, 2007.
ISNAD ŞİMŞEK, Ömer vd. "Endüstriyel nisin üretiminde etkili faktörler ve model sistemler". Mühendislik Bilimleri Dergisi 13/1 (2007), 57-67.
Sayfa Oluşturulma Tarihi
22-04-2024 12:23

İLETİŞİM

TÜBİTAK ULAKBİM TR Dizin

Yüzüncüyıl, İşçi Blokları Mahallesi

Muhsin Yazıcıoğlu Caddesi No:51/C

06530 Çankaya / ANKARA +90 (312) 298 92 00

trdizin@tubitak.gov.tr

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © Tüm Hakları Saklıdır. Gizlilik Politikası Kullanım Şartları