Objective: The relationship between skin diseases and psychological factors have been mentioned by may researchers. The aim of this study was to investigate the impact of two different kinds of skin disorders upon self-esteem. Method: The sample was composed of 50 vitiligo and chronic urticaria patients recruited from dermatology outpatient clinics of four major hospitals in Istanbul. The age range of the sample was 16-60 years. The control group was 50 healthy volunteers matched with age and education. We applied the sociodemographical data form developed by us, The Turkish version of the Structured Clinical Interview for DSM-IV Mental Disorders (SCID-I), Self-esteem Rating Scale (SERS). For statistical analysis SPSS for Windows 10.0 package programme was used. Results: The mean age of vitiligo group was 35.82±12.56, chronic urticaria group was 38.66±10.61 and control group was 35.98±12.49. 48 % of the vitiligo group was female and 52 % was male. 68 % of chronic urticaria group was female and 32 % was male. 50 % of the control group was female and 50 % was male. 58 % of the vitiligo group was married and 42 % was single. 70 % of the chronic urticaria group was married and 30 % was single. 68 % of the control group was married and 32 % was single. 60 % of the vitiligo group graduated from elementary school, 22 % from high school, 18 % from university. 70 % of the chronic urticaria group was from elementary school, 24 % from high school and 16 % from university. The total scores of the self-esteem of the control group were significantly higher than vitiligo and chronic urticaria group (p<0.001). The rates of dysthymic disorder and generalized anxiety disorder were found higher in the vitiligo and chronic urticaria group than control group (p<0.05), but the other diagnoses in SCID-I were not statistically different between patients and control group (p>0.05). Discussion and Conclusion: In our study, we found that the scores of self-esteem in patients with two different kinds of skin disorders were lower than control group (p<0.001), but there is no significant difference between the two patient groups. Although the rates of dysthymic disorder and generalized anxiety disorder in patient groups were higher than the control group, the prevalence of dysthymic disorder and generalized anxiety disorder was higher in chronic urticaria group than vitiligo group (p<0.05). While both of the skin disorders causes decrease in self-esteem, the rates of the comorbid psychiatric disorders along with skin disorders were different. Our findings were discussed in light of literature.