Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results

KARAÇAY, Özlem; KÖSE, Faruk Mehmet; BORAN, Nurettin; TULUNAY, Gökhan; AYKAN, Burcu; TURAN, Taner; KOC, SEVGİ

Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results

Faruk Mehmet KÖSE, (SSK Etlik Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi, Ankara, Türkiye)

Taner TURAN, (SSK Etlik Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi, Ankara, Türkiye)

Nurettin BORAN, (SSK Etlik Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi, Ankara, Türkiye)

Özlem KARAÇAY, (SSK Etlik Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi, Ankara, Türkiye)

Gökhan TULUNAY, (SSK Etlik Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi, Ankara, Türkiye)

Sevgi KOÇ, (SSK Etlik Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi, Ankara, Türkiye)

Burcu AYKAN (SSK Etlik Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi, Ankara, Türkiye)

Journal of the Turkish-German Gynecological Association

1 0

Yıl: 2006 Cilt: 7 Sayı: 4 Sayfa Aralığı: 302 - 305 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results

Öz:

Amaç: Evre III C-IV epitelyal over kanseri olan hastalarda “second-look laparotomi” (SLL) sonuçlarının ve bunları etkileyen prognostik faktörlerin belirlenmesi amaçlandı. Materyal ve Metot: Ocak 1998-Mart 2003 tarihleri arasında SLL yapılmış olan 75 hastaya ait medikal kayıtlar gözden geçirildi. SLL prosedürünün sonuçları ve SLL sonucu negatif olanlarda rekürrens oranları incelendi. Hasta yaşlının, klinik evrenin, histolojik grad düzeyinin, tümör boyutunun, histolojik tipin, asit varlığının, asit volümünün, peritoneal sitolojinin ve kemoterapi şeklinin SLL sonucu üzerindeki etkisi değerlendirildi. Sonuçlar: Hastaların yaş ortalaması 52 yıl ve ortalama takip süresi 39 aydı. Çalışmada 50 hasta paklitaksel/platin (alt› kür) ve 25 hasta epirubisin/paklitaksel/platin (altı kür) kemoterapisi aldı. Bu 75 hastanın 47’sinde (%62.7) SLL sonucu negatif, 15’inde (%20) mikroskopik, 13’ünde (%17.3) makroskopik olarak pozitifti. SLL sonucu negatif olan 47 hastanın 20’sinde (%42.6) nüks gelişti. Ortalama nüks zamanı 14.5 aydı. Asit volümüyle SLL’de rezidüel tümör saptanma olasılığı arasında pozitif ilişki saptandı (p<0.05). Klinik evrenin, histolojik tip ve grad düzeyinin, yaşın, tümör boyutunun, asit varlığının, sitoloji sonucunun SLL sonucu üzerine etkisi olmadığı belirlendi. Tartışma: SLL sonuçlarını etkileyen faktörleri tanımlayabilmek, SLL prosedürü yetersizliğinden dolayı zordur. SLL’nin genelde sağkalım oranlarını iyileştirmediği kabul edilmektedir. Sadece hastalığın o anki durumu hakkında fikir vermektedir.

Anahtar Kelime: Prognostik faktör Yumurtalık neoplazmları Neoplazmlar, glandüler ve epitelyal Laparotomi

Konular: Kadın Hastalıkları ve Doğum

İleri evre epitelyal over kanserlerinde second-look laparotomi ve bu sonuçları etkileyen faktörler

Öz:

Objective: The aim of the study was to determine the results of second-look laparotomy (SLL) in patients with stage III C and IV epithelial ovarian cancer and factors influencing the results. Materials and Methods: Medical records of seventy-five patients who underwent SLL between January 1998 and March 2003 were reviewed. The outcome of the SLL procedure and recurrence rates in SLL negative patients were evaluated. The effect of patient age, tumor stage, grade, size, and histological type, presence of ascites, volume of ascites, peritoneal cytology and type of chemotherapy on SLL results were also evaluated. Results: The mean age of the patients was 52 years and mean duration of follow-up was 39 months. In this study, fifty patients received paclitaxel/platinum (six courses) and twenty-five patients received epirubicin/paclitaxel/platinum (six courses) chemotherapy. Of these 75 patients, 47 (62.7%) were SLL negative, 15 (20%) had microscopic residual disease and 13 (17.3%) had gross macroscopic disease. Recurrence occurred in 20 (42.6%) of 47 SLL negative patients. The mean time to recurrence was 14.5 months. The volume of ascites correlated positively with the probability of finding residual tumor at SLL (p<0.05). Patient age, clinical stage, histological type and grade, tumor size, presence of ascites and result of peritoneal cytology were found not to influence the outcome of SLL. Discussion: It is difficult to determine the factors influencing the outcome of SLL because of the insadequacy of the procedure. It is generally considered that SLL doesn’t contribute to survival but only gives information about the state of the disease.

Anahtar Kelime: Neoplasms, Glandular and Epithelial Laparotomy Prognostic factor Ovarian Neoplasms

Konular: Kadın Hastalıkları ve Doğum

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KÖSE F, TURAN T, BORAN N, KARAÇAY Ö, TULUNAY G, KOC S, AYKAN B (2006). Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. , 302 - 305.
Chicago	KÖSE Faruk Mehmet,TURAN Taner,BORAN Nurettin,KARAÇAY Özlem,TULUNAY Gökhan,KOC SEVGİ,AYKAN Burcu Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. (2006): 302 - 305.
MLA	KÖSE Faruk Mehmet,TURAN Taner,BORAN Nurettin,KARAÇAY Özlem,TULUNAY Gökhan,KOC SEVGİ,AYKAN Burcu Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. , 2006, ss.302 - 305.
AMA	KÖSE F,TURAN T,BORAN N,KARAÇAY Ö,TULUNAY G,KOC S,AYKAN B Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. . 2006; 302 - 305.
Vancouver	KÖSE F,TURAN T,BORAN N,KARAÇAY Ö,TULUNAY G,KOC S,AYKAN B Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. . 2006; 302 - 305.
IEEE	KÖSE F,TURAN T,BORAN N,KARAÇAY Ö,TULUNAY G,KOC S,AYKAN B "Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results." , ss.302 - 305, 2006.
ISNAD	KÖSE, Faruk Mehmet vd. "Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results". (2006), 302-305.

APA	KÖSE F, TURAN T, BORAN N, KARAÇAY Ö, TULUNAY G, KOC S, AYKAN B (2006). Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. Journal of the Turkish-German Gynecological Association, 7(4), 302 - 305.
Chicago	KÖSE Faruk Mehmet,TURAN Taner,BORAN Nurettin,KARAÇAY Özlem,TULUNAY Gökhan,KOC SEVGİ,AYKAN Burcu Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. Journal of the Turkish-German Gynecological Association 7, no.4 (2006): 302 - 305.
MLA	KÖSE Faruk Mehmet,TURAN Taner,BORAN Nurettin,KARAÇAY Özlem,TULUNAY Gökhan,KOC SEVGİ,AYKAN Burcu Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. Journal of the Turkish-German Gynecological Association, vol.7, no.4, 2006, ss.302 - 305.
AMA	KÖSE F,TURAN T,BORAN N,KARAÇAY Ö,TULUNAY G,KOC S,AYKAN B Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. Journal of the Turkish-German Gynecological Association. 2006; 7(4): 302 - 305.
Vancouver	KÖSE F,TURAN T,BORAN N,KARAÇAY Ö,TULUNAY G,KOC S,AYKAN B Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results. Journal of the Turkish-German Gynecological Association. 2006; 7(4): 302 - 305.
IEEE	KÖSE F,TURAN T,BORAN N,KARAÇAY Ö,TULUNAY G,KOC S,AYKAN B "Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results." Journal of the Turkish-German Gynecological Association, 7, ss.302 - 305, 2006.
ISNAD	KÖSE, Faruk Mehmet vd. "Results of second-look laparotomy in advanced stage epithelial ovarian cancer and factors influencing the results". Journal of the Turkish-German Gynecological Association 7/4 (2006), 302-305.