The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage

KIZILTUNÇ, Ahmet; YILDIRGAN, Mehmet İlhan; BAŞOĞLU, Mahmut; ÖREN, Durkaya; Atamanalp, Sabri Selcuk; POLAT, Kamil Yalçın; ÖZTÜRK, Gürkan; Gündoğdu, Cemal; AYDINLI, Bülent; Gürsan, Nesrin; Suleyman, Halis

The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage

Bülent AYDINLI, (Atatürk Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Erzurum, Türkiye)

Mehmet İlhan YILDIRGAN, (Atatürk Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Erzurum, Türkiye)

Gürkan ÖZTÜRK, (Atatürk Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Erzurum, Türkiye)

Sabri Selçuk ATAMANALP, (Atatürk Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Erzurum, Türkiye)

Kamil Yalçın POLAT, (Atatürk Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Erzurum, Türkiye)

Mahmut BAŞOĞLU, (Atatürk Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Erzurum, Türkiye)

Cemal GÜNDOĞDU, (Atatürk Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Erzurum, Türkiye)

Halis SÜLEYMAN, (Atatürk Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Erzurum, Türkiye)

Ahmet KIZILTUNÇ, (Atatürk Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Erzurum, Türkiye)

Nesrin GÜRSAN, (Atatürk Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Erzurum, Türkiye)

Durkaya ÖREN, (Atatürk Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Erzurum, Türkiye)

Diğer Yazarlar

Ulusal Travma ve Acil Cerrahi Dergisi

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Yıl: 2007 Cilt: 13 Sayı: 4 Sayfa Aralığı: 268 - 273 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage

Öz:

AMAÇ: İndometazinle oluşturulan sıçan mide ülseri modelinde sildenafil sitratın (SS) koruyucu etkileri araştırıldı. GEREÇ-YÖNTEM: Mide ülserleri indometazinin oral yoldan verilmesiyle oluşturuldu. Çalışmada 30 sıçan kullanıldı. Sıçanlar 3 gruba ayrıldı; 50 mg/kg dozunda SS (n=10) veya omeprazol (n=10) verildi ya da hiç tedavi verilmedi (n=10, kontrol grubu). Ülser alanlarının toplamına ilave olarak, mide dokusundaki NO düzeylerini saptamak amacıyla mide dokusunda nitrit (NO2-) ve nitrat (NO3-) düzeyleri değerlendirildi. Tüm ölçümler indometazinin oral uygulamasından 6 saat sonra yapıldı. BULGULAR: Ülser alanlarının ortalaması SS, omeprazol ve kontrol grubunda sırasıyla 4,0±2,31, 3,0±2,00 ve 21,4±8,43 olarak ölçüldü. SS grubunda ortalama ülserasyon alanları kontrol grubuna göre daha düşük değerlerde saptandı. Mide dokusundaki NO içeriği SS, omeprazol ve kontrol grubunda sırasıyla 32,2±3,05, 24,8±3,23 ve 21,0±0,82 (µmol/g protein) şeklindeydi. NO muhtevası SS grubunda kontrol grubuna göre ciddi şekilde yüksekti (p<0,001). SONUÇ: Sildenafil sitratın mide mukozasını indometazine bağlı oluşan hasardan koruyucu rolü olabilir. Bu etki NO’nun mide dokusundaki yükselmiş olan düzeylerine bağlı olabilir.

Anahtar Kelime: sildenafil Anti-ülser ajanları Nitrik oksit Piperazinler Omeprazol İlaç uygulama, oral Hastalık modelleri, hayvan Pürin Fosfodiesteraz inhibitörleri Sulfonlar Anti-enflamatuvar ajanlar, steroid olmayan İndometazin Sıçan, Sprague-Dawley Mide ülseri

Konular: Cerrahi

Sildenafil sitrat’ın gastrik mukozayı non-steroid antienflamatuvar ilaçlara bağlı oluşan hasardan korumadaki rolü

Öz:

BACKGROUND: To investigate the protective effects of sildenafil citrate (SC) on indomethacin-induced gastric ulcer in a rat model. METHODS: Gastric ulcers were induced by oral ingestion of indomethacin. Thirty rats were used in the study. The rats were divided into 3 groups, and given either SC (n=10) at a dose of 50 mg/kg or omeprazole (n=10), or no treatment (n=10, the control group). In addition to the measurements of ulceration areas, the sum of gastric tissue nitrite (NO2-) and nitrate (NO3-) were evaluated as an indicator of gastric tissue NO level. All the measurements were done at 6th hour of oral administration of indomethacin. RESULTS: The mean values of ulceration areas were 4.0±2.31, 3.0±2.00, and 21.4±8.43 in the SC, omeprazole and control groups, respectively. The mean values of ulceration areas in the SC-treated group was lower than that of the control group. The contents of NO were 32.2±3.05, 24.8±3.23 and 21.0±0.82 (µmol/g protein) in gastric tissue in indomethacin, SC, omeprazole and control groups, respectively, The content of NO in the SC-treated groups was significantly higher than control group (p<0.001). CONCLUSION: Sildenafil citrate may have a role in protecting gastric mucosa from the damage caused by indomethacin. This effect may be associated with the increased level of NO in gastric tissue

Anahtar Kelime: Sulfones Anti-Inflammatory Agents, Non-Steroidal Indomethacin Rats, Sprague-Dawley Stomach Ulcer sildenafil Anti-Ulcer Agents Nitric Oxide Piperazines Omeprazole Administration, Oral Disease Models, Animal Purines Phosphodiesterase Inhibitors

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AYDINLI B, YILDIRGAN M, ÖZTÜRK G, Atamanalp S, POLAT K, BAŞOĞLU M, Gündoğdu C, Suleyman H, KIZILTUNÇ A, Gürsan N, ÖREN D (2007). The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. , 268 - 273.
Chicago	AYDINLI Bülent,YILDIRGAN Mehmet İlhan,ÖZTÜRK Gürkan,Atamanalp Sabri Selcuk,POLAT Kamil Yalçın,BAŞOĞLU Mahmut,Gündoğdu Cemal,Suleyman Halis,KIZILTUNÇ Ahmet,Gürsan Nesrin,ÖREN Durkaya The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. (2007): 268 - 273.
MLA	AYDINLI Bülent,YILDIRGAN Mehmet İlhan,ÖZTÜRK Gürkan,Atamanalp Sabri Selcuk,POLAT Kamil Yalçın,BAŞOĞLU Mahmut,Gündoğdu Cemal,Suleyman Halis,KIZILTUNÇ Ahmet,Gürsan Nesrin,ÖREN Durkaya The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. , 2007, ss.268 - 273.
AMA	AYDINLI B,YILDIRGAN M,ÖZTÜRK G,Atamanalp S,POLAT K,BAŞOĞLU M,Gündoğdu C,Suleyman H,KIZILTUNÇ A,Gürsan N,ÖREN D The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. . 2007; 268 - 273.
Vancouver	AYDINLI B,YILDIRGAN M,ÖZTÜRK G,Atamanalp S,POLAT K,BAŞOĞLU M,Gündoğdu C,Suleyman H,KIZILTUNÇ A,Gürsan N,ÖREN D The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. . 2007; 268 - 273.
IEEE	AYDINLI B,YILDIRGAN M,ÖZTÜRK G,Atamanalp S,POLAT K,BAŞOĞLU M,Gündoğdu C,Suleyman H,KIZILTUNÇ A,Gürsan N,ÖREN D "The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage." , ss.268 - 273, 2007.
ISNAD	AYDINLI, Bülent vd. "The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage". (2007), 268-273.

APA	AYDINLI B, YILDIRGAN M, ÖZTÜRK G, Atamanalp S, POLAT K, BAŞOĞLU M, Gündoğdu C, Suleyman H, KIZILTUNÇ A, Gürsan N, ÖREN D (2007). The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. Ulusal Travma ve Acil Cerrahi Dergisi, 13(4), 268 - 273.
Chicago	AYDINLI Bülent,YILDIRGAN Mehmet İlhan,ÖZTÜRK Gürkan,Atamanalp Sabri Selcuk,POLAT Kamil Yalçın,BAŞOĞLU Mahmut,Gündoğdu Cemal,Suleyman Halis,KIZILTUNÇ Ahmet,Gürsan Nesrin,ÖREN Durkaya The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. Ulusal Travma ve Acil Cerrahi Dergisi 13, no.4 (2007): 268 - 273.
MLA	AYDINLI Bülent,YILDIRGAN Mehmet İlhan,ÖZTÜRK Gürkan,Atamanalp Sabri Selcuk,POLAT Kamil Yalçın,BAŞOĞLU Mahmut,Gündoğdu Cemal,Suleyman Halis,KIZILTUNÇ Ahmet,Gürsan Nesrin,ÖREN Durkaya The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. Ulusal Travma ve Acil Cerrahi Dergisi, vol.13, no.4, 2007, ss.268 - 273.
AMA	AYDINLI B,YILDIRGAN M,ÖZTÜRK G,Atamanalp S,POLAT K,BAŞOĞLU M,Gündoğdu C,Suleyman H,KIZILTUNÇ A,Gürsan N,ÖREN D The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. Ulusal Travma ve Acil Cerrahi Dergisi. 2007; 13(4): 268 - 273.
Vancouver	AYDINLI B,YILDIRGAN M,ÖZTÜRK G,Atamanalp S,POLAT K,BAŞOĞLU M,Gündoğdu C,Suleyman H,KIZILTUNÇ A,Gürsan N,ÖREN D The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. Ulusal Travma ve Acil Cerrahi Dergisi. 2007; 13(4): 268 - 273.
IEEE	AYDINLI B,YILDIRGAN M,ÖZTÜRK G,Atamanalp S,POLAT K,BAŞOĞLU M,Gündoğdu C,Suleyman H,KIZILTUNÇ A,Gürsan N,ÖREN D "The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage." Ulusal Travma ve Acil Cerrahi Dergisi, 13, ss.268 - 273, 2007.
ISNAD	AYDINLI, Bülent vd. "The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage". Ulusal Travma ve Acil Cerrahi Dergisi 13/4 (2007), 268-273.