Yıl: 2004 Cilt: 15 Sayı: 1-2 Sayfa Aralığı: 91 - 96 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Toksikolojide serbest radikallerin önemi

Öz:
Bu makalede, toksikolojide serbest radikallerle ilgili son bilgilerin bir özetinin sunulması amaçlandı. Medline, Pubmed, Sciencedirect gibi veritabanlarını kullanarak bir literatür taraması yapıldı. İncelenen ilgili bütün makaleler özetlenip bu çalısmada sunuldu.
Anahtar Kelime: karbon tetraklorür toksik maddeler genel bakış zararlı öldürücüler hepatotoksinler serbest radikaller toksikoloji bilgi toksisite antioksidanlar

Konular: Veterinerlik

Importance of free radicals in toxicology

Öz:
In this paper, to present a brief review of recent data regarding free radicals in toxicology was purposed. A search of the literature was performed using medical database e.g. Medline, Pubmed, Sciencedirect. Studied all relevant articles were summarized and presented in this paper.
Anahtar Kelime: toxicity antioxidants carbon tetrachloride toxic substances reviews pesticides hepatotoxins free radicals toxicology information

Konular: Veterinerlik
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1.Abdollahi M, Bahreini-Moghadam A, Emmami B, Fooladian F, Zafariet K, (2003) : Increasing intracellular cAMP and cGMP inhibits cadmium-induced oxidative stress in rat submandibular saliva. Comp. Biochem. Physol. C, 135: 331-336.
  • 2.Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaie A, (2004) : Pesticides and oxidative stress : a review. Med. Sci. Monit., 10: 141-147.
  • 3.Akkuş İ, (1995) : Serbest Radikaller ve Fizyopatolojik Etkileri. Mimoza Yayınları No 38, Saglık dizisi 5, Konya.
  • 4.Alıcıgüzel Y, Özdem S, Demir AY, Ünal F, Kumbul D, Özdem SS, Perry G, Smith MA, (2001) : Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro. Redox Rep., 6: 153-154.
  • 5.Altuntaş İ, Delibaş N, Doğuca DK, Özmen S, Gültekin F, (2003) : Role of reactive oxygen species in organophosphate insecticide phosalone toxicity in erythrocytes in vitro. Toxicology In Vitro, 17: 153-157.
  • 6.Bachowski S, Kolaja KL, Xu Y, Ketcham CA, Stevenson DE, Walborg EF, Klaunig JE, (1997) : Role of oxidative stress in the mechanism of dieldrin’s hepatotoxicity. Ann. Clin. Lab. Sci., 27: 196-209.
  • 7.Bagchi D, Bagchi M, Hassoun EA, Stohs SJ, (1995) : In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticide. Toxicology, 104: 129-140.
  • 8.Bao YP, Williamson G, Tew D, Plumb GW, Lambert N, Jones JG, Menon DK, (1998) : Antioxidant effects of propofol in human hepatic microsomes: concentration effects and clinical relevance. British J. Anaesth., 81: 584-589.
  • 9.Chugh SN, Arora V, Sharma A, Chugh K, (1996) : Free radical scavengers and lipid peroxidation in acute aluminium phosphide poisoning. Indian J. Med. Res., 104: 190-193.
  • 10.Cochranc CG, (1991) : Cellular injury by oxidants. Am. J. Med., 92: 235-305.
  • 11.Cross CE, Halliwell B, Borish ET, Pryor WA, Ames BN, Saul RL, McCord JM, Harman D, (1987) : Oxygene radicals and human disease. Ann. Intern. Med., 107: 526-545.
  • 12.Çenesiz S, Özcan A, (2003): Deneysel kronik florozis olusturulmus Tuj ırkı koyunlarda eritrosit süperoksit dismutaz, katalaz ve glutasyon peroksidaz aktivitelerinin arastırılması. Kafkas Ü. Vet. Fak. Derg., 9: 161-164.
  • 13.El-Demerdash FM, Yousef MI, Kedwany FS, Baghdadi HH, (2004) : Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and beta-carotene. Food Chem. Toxicol., 42: 1563-1571.
  • 14.Facchinetti F, Dawson VL, Dawson TM, (1998) : Free radicals as mediators of neuronal injury. Cell. Mol. Neurobiol., 18: 667-682.
  • 15.Gangadharan B, (2001) : Effect of methoxychlor on antioxidant system of goat epididymal sperm in vitro. B. Asian J. Androl., 3: 285-88.
  • 16.Gupta A, (1999) : Effect of pyrethroid-based liquid mosquito repellent inhalation on the blood-brain barrier function and oxidative damage in selected organs of developing rats. J. Appl. Toxicol., 19: 67-72.
  • 17.Gültekin F, Öztürk M, Akdoğan M, (2000) : The effect of organophosphate insecticide chlorpyrifosethyl on lipid peroxidation and antioxidant enzymes (in vitro). Arch. Toxicol., 74: 533-538.
  • 18.Gültekin F, Delibaş N, Yaşar S, Kılınç İ, (2001) : In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats. Arch. Toxicol., 75: 88-96.
  • 19.Güven A, Erginsoy S, Kaya N, (2003) : Kazlarda karbon tetraklorür zehirlenmesinin biyokimyasal ve patolojik parametrelere etkisi. Kafkas Ü. Vet. Fak. Derg., 9: 131-136.
  • 20.Janssen YMW, Houten BV, Borm PJA, Mossman BT, (1993) : Biology of disease, cell and tissue responses to oxidative damage. Lab. Invest., 69: 261-274.
  • 21.Joence H, (1989) : Genetic toxicology of oxygene. Mutation Res., 219: 193-208.
  • 22.Kale M, Rathore N, John S, Bhathagar D, (1999) : Lipid peroxidative damage on pyrethroid exposure and alteration in antioxidant status in rat erythrocytes. A possible involvement of reactive oxygen species. Toxicol. Lett., 105: 197-205.
  • 23.Kalender S, Kalender Y, Öğütçü A, Uzunhisarcıklı M, Durak D, Açıkgöz F, (2002) : Endosulfan-induced cardiotoxicity and free radical metabolism in rats : the protective effect of vitamin E. Toxicology, 202: 227-235.
  • 24.Kanthasamy AG, Ardelt B, Malave A, Mills EM, Powley TL, Borowitz JL, Isom GE, (1997) : Reactive oxygen species generated by cyanide mediated toxicity in rat pheochromocytoma cells. Toxicol. Lett., 93: 47-54.
  • 25.Kawanishi S, Hiraku Y, Murata M, Oikawa S, (2002) : The role of metals in site-specific DNA damage with reference to carcinogenesis. Free Radical Biol. Med., 32: 822-832.
  • 26.Kaya S, Pirinççi İ, Bilgili A, (1998) : Veteriner Hekimliginde Toksikoloji. Medisan Yayın Serisi: 35, Ankara, s. 222, 232, 273, 276, 355.
  • 27.Kehrer JP, (1993) : Free radical as mediator of tissue injury and disease. Crit. Rew. Toxicol., 23: 21-48.
  • 28.Koner BC, Banerjee BD, Ray A, (1998) : Organochlorine pesticide-induced oxidative stress and immune suppression in rats. Indian J. Exp. Biol., 36:395- 398.
  • 29.Krajcovicova-Kudlackova M, Paukova V, Bacekova M, Dusinska M, (2004) : Lipid peroxidation in relation to vitamin C and vitamin E levels. Cent. Eur. J. Public Health., 12:46-48.
  • 30.Liu J, Kadiiska MB, Corton JC, Qu W, Waalkes M, Mason RP, Liu Y, Klaassen CD, (2002) : Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice. Free Radical Biol. Med., 32: 525-535.
  • 31.Lunec J, (1990) : Free radicals: their involvement in disease processes. Ann. Clin. Biochem., 27: 173-182.
  • 32.Maiti PK, Kor A, Gupta P, Chaurassia SS, (1995) : Loss of membrane integrity and inhibition of type-1 iodothyronine 5-monoeiodinase activity by fenvalerate in female mouse. Biochem. Biophys. Res. Commun., 214: 905-909.
  • 33.Matés JM, (2000) : Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology, 153: 83-104.
  • 34.McCay PB, Lai EK, Payer JL, Dubose CM, Janzen EG, (1984) : Oxygen and carbon centered radical formation during carbon tetrachloride metabolism. J. Biol. Chem., 259: 2135-2143.
  • 35.Mollace V, Lannone M, Muscoli C, Palma E, Granato T, Rispoli V, Nistico R, Rotiroti D, Salvemini D, (2003) : The role of oxidative stress in paraquatinduced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic. Neurosci. Lett., 335: 163- 166.
  • 36.Nagy IZ, (1990) : Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone : a review. Arch. Gerontol. Geriat., 11: 177-186.
  • 37.Niki E, (1987) : Antioxidant in relation to lipid peroxidation. Chem. Phy. Lipids, 44: 227-253.
  • 38.Özdem SS, Sadan G, (1994) : Serbest oksijen radikallerinin olusumu ve klinik açıdan önemi. Akdeniz Ü. Tıp Fak. Derg., 11: 63-71.
  • 39.Paula EM, Mathangi DC, Namasivayam A, (2003) : Free radical changes in methanol toxicity. Indian J. Physiol. Pharmacol., 47: 207-211.
  • 40.Placer CA, Cushman LL, Johnson BC, (1990) : Estimation of product of lipid peroxidation (Malondy Dialdehyde) in biochemical systems. Anal. Biochem., 16: 259-264.
  • 41.Pohl LR, Mico BA, (1984) : Electrophilic halogens as potentially toxic metabolites of halogenated compounds. Trends Pharmacol. Sci. 5: 61-64.
  • 42.Porter NA, (1984) : Chemistry of lipid peroxidation. Methods Enzymol., 105: 273-283.
  • 43.Rahman IU, Massaro D, (1992) : Endotoxin treatment protects rats against ozone-induced lung edema: with evidence for the role of manganese superoxide dismutase. Toxicol. Appl. Pharmacol., 113: 13–18.
  • 44.Rao MV, Avani G, (2004) : Arsenic induced free radical toxicity in brain of mice. Indian J. Exp. Biol., 42: 495-498.
  • 45.Rzeuski R, Chlubek D, Machoy Z, (1998) : Interactions between fluoride and biological free radical reactions. Fluoride, 31: 43-45.
  • 46.Shanthakumari D, Srinivasalu S, Subramanian S, (2004) : Effect of fluoride intoxication on lipid peroxidation and antioxidation status in experimental rats. Toxicology, 204: 219-228.
  • 47.Shivarajashankara YM, Shivashankara AR, Rao SH, Bhat PG, (2001) : Oxidative stress in children with endemic skeletal fluorosis. Fluoride, 34: 103-107.
  • 48.Sinclair AJ, Barnett AH, Junec J, (1990) : Free radicals and antioxidant systems in health and disease. British J. Hosp. Med., 43: 334-344.
  • 49.Soltaninejad K, Kebriaeezadeh A, Minaiee B, Ostad SN, Hosseini R, Azizi E, Abdollahi M, (2003) : Biochemical and ultrastructural evidences for toxicity of lead through free radicals in rat brain. Hum. Exp. Toxicol., 22: 417-423.
  • 50.Spallholz JE, (1994) : On the nature of selenium toxicity and carsinostatic activity. Free Radical Biol. Med., 17: 45-64.
  • 51.Stombeck DR, Guilford WG, (1990) : Small Animal Gastroenterology. 2nd edit. Stongate publishing Co., California.
  • 52.Swierczynski J, Kochan Z, Mayer D, (1997) : Dietary İ-tocopherol prevents dehydropiandrosteroneinduced lipid peroxidation in rat liver microsomes and mitochondria. Toxicol. Lett., 91: 129-136.
  • 53.Sener S, Yıldırım M, (2000) : Toksikoloji, Teknik Yayıncılık, İstanbul, s. 42.
  • 54.Urani C, Crippa S, Camatini M, (1998) : Cellular and molecular responses of metal-induced toxicity. Toxicol. Lett., suppl. 1:195.
  • 55.Vural N, (1984 ) : Toksikoloji. A. Ü. Ecz. Fak. Yay. No 56, Ankara, s.179, 384, 464.
  • 56.Yagi K, (1994) : Lipid peroxidase and related radicals in clinical medicine. (in) Free Radicals in Diagnostic Medicine. D Armstrong (Editor), pp. 17-27, Plenum Press, New York.
  • 57.Zhou JF, Zhou W, Zhang SM, Luo YE, Chen HH, (2004) : Oxidative stress and free radical damage in patients with acute dipterex poisoning. Biomed. Environ. Sci., 17: 223-233.
APA mercan yücel u (2004). Toksikolojide serbest radikallerin önemi. , 91 - 96.
Chicago mercan yücel ufuk Toksikolojide serbest radikallerin önemi. (2004): 91 - 96.
MLA mercan yücel ufuk Toksikolojide serbest radikallerin önemi. , 2004, ss.91 - 96.
AMA mercan yücel u Toksikolojide serbest radikallerin önemi. . 2004; 91 - 96.
Vancouver mercan yücel u Toksikolojide serbest radikallerin önemi. . 2004; 91 - 96.
IEEE mercan yücel u "Toksikolojide serbest radikallerin önemi." , ss.91 - 96, 2004.
ISNAD mercan yücel, ufuk. "Toksikolojide serbest radikallerin önemi". (2004), 91-96.
APA mercan yücel u (2004). Toksikolojide serbest radikallerin önemi. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, 15(1-2), 91 - 96.
Chicago mercan yücel ufuk Toksikolojide serbest radikallerin önemi. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi 15, no.1-2 (2004): 91 - 96.
MLA mercan yücel ufuk Toksikolojide serbest radikallerin önemi. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, vol.15, no.1-2, 2004, ss.91 - 96.
AMA mercan yücel u Toksikolojide serbest radikallerin önemi. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi. 2004; 15(1-2): 91 - 96.
Vancouver mercan yücel u Toksikolojide serbest radikallerin önemi. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi. 2004; 15(1-2): 91 - 96.
IEEE mercan yücel u "Toksikolojide serbest radikallerin önemi." Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, 15, ss.91 - 96, 2004.
ISNAD mercan yücel, ufuk. "Toksikolojide serbest radikallerin önemi". Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi 15/1-2 (2004), 91-96.