Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children

ÇOLAK, Ömer; KILIÇ, Zübeyir; UÇAR, Birsen; DİNLEYİCİ, Ener Çağrı; GÜNEŞ, Erdoğan

Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children

Birsen UÇAR, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Pediatrik Kardiyoloji Anabilim Dalı, Eskişehir, Türkiye)

Zübeyir KILIÇ, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Pediatrik Kardiyoloji Anabilim Dalı, Eskişehir, Türkiye)

Ener Çağrı DİNLEYİCİ, (Osmangazi Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Eskişehir, Türkiye)

Ömer ÇOLAK, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Eskişehir, Türkiye)

Erdoğan GÜNEŞ (Osmangazi Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Eskişehir, Türkiye)

Anadolu Kardiyoloji Dergisi

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Yıl: 2007 Cilt: 7 Sayı: 4 Sayfa Aralığı: 415 - 420 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children

Öz:

Amaç: Dislipidemin erken dönemde saptanması ve uzun süreli korumada ateroskleroz için tanımlanmış risk faktörlerinin erken dönemdekontrolünün çocukluk yaş grubunda başlanması önerilmektedir. Bu çalışmada çocuklarda serum yüksek dansiteli lipoprotein dışı kolesterol (non-HDL-K) düzeylerine göre dislipidemi prevalansının belirlenmesi ve serum non-HDL-K düzeylerinin yaş grupları, cinsiyet ve yaşam alanına göre değerlendirilmesi planlandı.Yöntemler: Eskişehir kent ve kırsal bölgesinde yaşayan 7-18 yaşları arasında 2896 çocuk (1467 kız, 1429 erkek) bu randomize kros-seksiyonel çalışmaya alındı. Tüm çocuklarda serum non-HDL-K, total kolesterol (TK) and trigliserid (TG) düzeyleri ölçüldü. İstatistiksel analizde lipid parametrelerin karşılaştırması Student bağımsız örneklem T testi ile yapıldı. Lipid parametrelerin yaş, antropometrik ölçümleri, total vücut yağ yüzdesi ile ilişkileri Pearson korelasyon testi ile incelendi.Bulgular: Serum non HDL-K düzeyleri kız çocuklarında (115.5±31.5 mg/dl) erkek çocuklarına (106.7±30.2mg/dl) göre yüksek olarak saptandı (p<0.001). Yedi-10 yaş grubundaki kız çocuklarında serum non-HDL-K düzeyleri 11-14 yaş ve 15-18 yaş grubundaki kız çocuklarından yüksek olarak saptandı (sırasıyla p<0.01, p<0.05). Yedi-10 yaş grubundaki erkek çocuklarında serum non-HDL-K düzeyleri, 11-14 yaş ve 15-18 yaş grubundaki erkek çocuklarından yüksek olarak saptandı (her iki grup için de p<0.001). Serum non-HDL-K, total kolesterol ve trigliserid düzeyleri 7-10 yaş grubunda, kız çocuklarında erkek çocuklarından yüksek olarak saptandı. Serum total kolesterol, LDL-K ve HDL-K düzeyleri kentlerde yaşayan çocuklarda yüksek olarak saptanırken, serum trigliserid düzeyleri kırsal alanda yaşayan çocuklarda yüksek olarak saptandı (p<0.001). Serum non-HDL-K düzeyleri için kentsel ve kırsal alanda yaşayan çocuklarda fark saptanmadı (p>0.05). Her iki cinsiyette de serum non-HDL-K düzeyleri yaş ve HDL-K dışındaki diğer lipid parametreleri ile pozitif, serum HDL-K düzeyleri ile negatif korelasyon saptandı. Erkek çocuklarında, serum non-HDL-K düzeyleri aynı zamanda total vücut yağ yüzdesi, vücut ağırlığı ve boy ile korelasyon saptandı. Serum non-HDL-K düzeylerine göre dislipidemi prevalansı kız çocuklarında (%13.2) erkek çocuklarına (%8.9) göre yüksek olarak saptandı (p<0.001). Serum non-HDL-K düzeylerine göre dislipidemi prevalansı kentte yaşayan çocuklarda kırsal alanda yaşayan çocuklara göre yüksek olarak saptandı (p<0.05). Çocuklarda serum non-HDL-K düzeylerine göre dislipidemi prevalansı serum LDL-K düzeylerine göre dislipidemi prevalansı ile benzerdi.Sonuç: Çalışmamızın sonunda çocuklarda dislipidemi prevalansı beklenenden yüksek olarak saptandı. Ayrıca çocukluk çağında dislipideminin saptanmasında serum non-HDL-K düzeylerinin kullanılabileceği sonucuna varıldı.

Anahtar Kelime: Egzersiz Antropometri Hiperlipidemiler Kolesterol, HDL Çocuk Lipidler Yaygınlık Testlerin kestirim değeri Trigliseridler Kolesterol, LDL

Konular: Kalp ve Kalp Damar Sistemi

Türk okul çocuklarında serum lipid profili ve non-HDL kolesterol düzeyleri

Öz:

Objective: Early detection of dyslipidemia and long-term prevention of atherosclerosis by controlling risk factors should begin in childhood. The purpose of this study was to evaluate the prevalence of dyslipidemia according to non-high density lipoprotein cholesterol (non-HDL-C) levels in children and also evaluate serum non-HDL-C levels according to age groups, gender difference and living areas.Methods: Overall, 2896 children (1467 girls, 1429 boys) aged between 7-18 years, residing in urban and rural parts of Eskişehir, Turkey, were enrolled in this randomized cross-sectional study. Serum non-HDL-C, total cholesterol (TC) and triglyceride (TG) levels were assessed in allparticipants of the study. Statistical analysis was performed Student's independent-samples T test for comparison of lipid parameters andrelations between lipid parameters and age, anthropometric measurements, body fat percentage were evaluated by Pearson correlation test.Results: Serum non-HDL-C levels were significantly higher in girls (115.5±31.5mg/dl) than boys (106.7±30.2 mg/Dl) (p<0.001). For girls, serumnon-HDL-C levels were higher in 7-10 year age group than in 11-14-year and 15-18-year age groups (p<0.01 and p<0.05, respectively). For boys serum non-HDL-C levels of 7-10 year age group were significantly higher than in 11-14-year and 15-18-year age groups (p<0.001 for both). Serum non-HDL-C, total cholesterol and triglyceride levels were higher in girls than in boys especially in the 7-10-year-old age group. Serum TC,LDL-C, and HDL-C levels were higher in urban area residents, while serum TG levels were higher in rural area residents (p<0.001). Serumnon-HDL-C levels were similar in residents of different living areas (p>0.05). In both sexes, non-HDL-C levels positively correlated with age and lipid parameters except HDL-C levels and also negatively correlated with HDL-C levels. In boys, non-HDL-C levels also correlated with total body fat percentage, weight, height. The prevalence of dyslipidemia according to non-HDL-C levels was higher (13.2%) in girls than boys (8.9%) (p<0.001). The prevalence of elevated non-HDL-C levels was higher in urban area residents than in rural area residents (p<0.05). The dyslipidemia prevalence according to non-HDL-C levels was similar with dyslipidemia prevalence according to serum LDL-C levels.Conclusion: Our results are indicative of the prevalence of dyslipidemia in children is considerably common in our population. Serumnon-HDL-C levels could be used as an appropriate tool for detecting dyslipidemia in childhood.

Anahtar Kelime: Cholesterol, HDL Child Lipids Prevalence Predictive Value of Tests Triglycerides Cholesterol, LDL Exercise Anthropometry Hyperlipidemias

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	UÇAR B, KILIÇ Z, DİNLEYİCİ E, ÇOLAK Ö, GÜNEŞ E (2007). Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. , 415 - 420.
Chicago	UÇAR Birsen,KILIÇ Zübeyir,DİNLEYİCİ Ener Çağrı,ÇOLAK Ömer,GÜNEŞ Erdoğan Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. (2007): 415 - 420.
MLA	UÇAR Birsen,KILIÇ Zübeyir,DİNLEYİCİ Ener Çağrı,ÇOLAK Ömer,GÜNEŞ Erdoğan Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. , 2007, ss.415 - 420.
AMA	UÇAR B,KILIÇ Z,DİNLEYİCİ E,ÇOLAK Ö,GÜNEŞ E Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. . 2007; 415 - 420.
Vancouver	UÇAR B,KILIÇ Z,DİNLEYİCİ E,ÇOLAK Ö,GÜNEŞ E Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. . 2007; 415 - 420.
IEEE	UÇAR B,KILIÇ Z,DİNLEYİCİ E,ÇOLAK Ö,GÜNEŞ E "Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children." , ss.415 - 420, 2007.
ISNAD	UÇAR, Birsen vd. "Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children". (2007), 415-420.

APA	UÇAR B, KILIÇ Z, DİNLEYİCİ E, ÇOLAK Ö, GÜNEŞ E (2007). Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. Anadolu Kardiyoloji Dergisi, 7(4), 415 - 420.
Chicago	UÇAR Birsen,KILIÇ Zübeyir,DİNLEYİCİ Ener Çağrı,ÇOLAK Ömer,GÜNEŞ Erdoğan Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. Anadolu Kardiyoloji Dergisi 7, no.4 (2007): 415 - 420.
MLA	UÇAR Birsen,KILIÇ Zübeyir,DİNLEYİCİ Ener Çağrı,ÇOLAK Ömer,GÜNEŞ Erdoğan Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. Anadolu Kardiyoloji Dergisi, vol.7, no.4, 2007, ss.415 - 420.
AMA	UÇAR B,KILIÇ Z,DİNLEYİCİ E,ÇOLAK Ö,GÜNEŞ E Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. Anadolu Kardiyoloji Dergisi. 2007; 7(4): 415 - 420.
Vancouver	UÇAR B,KILIÇ Z,DİNLEYİCİ E,ÇOLAK Ö,GÜNEŞ E Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. Anadolu Kardiyoloji Dergisi. 2007; 7(4): 415 - 420.
IEEE	UÇAR B,KILIÇ Z,DİNLEYİCİ E,ÇOLAK Ö,GÜNEŞ E "Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children." Anadolu Kardiyoloji Dergisi, 7, ss.415 - 420, 2007.
ISNAD	UÇAR, Birsen vd. "Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children". Anadolu Kardiyoloji Dergisi 7/4 (2007), 415-420.