It has been inevitable to discuss the concept of urban transformation intensively for Istanbul due to some reasons like having experienced the rapid transformation for the last 20 years, being in real estate and annuity based growth in this process, approximately % 60 of building stock not being strong and sound enough to resist earthquake. 1999 Marmara earthquake experience has introduced the necessity to plan earthquake preparation studies in Turkey within an integrated system. Designation of a provisional settlement area, associate the reserved places with the urban plans, provision of equipment in neighborhood unit at provisional housing areas and interassociation of the design of prefabricated housing units that form the neighborhood unit and the performance of earthquake preparation studies within this process must be adopted as a new approach. The results of 1999 Marmara earthquake has entailed the formation of “planning, design and management” systematic of earthquake preparation studies in Turkey. While the sensitivity of Turkey and Marmara to earthquake preparation studies increases, another issue of cooperation is reinforcement and the determination of areas that will start “urban regeneration acceleration” rapidly in areas where reinforcement is not sufficient, and the use of urban transformation as a tool in damage reduction studies However, there are still important deficiencies for the urban regeneration and the production of preparation policies for earthquake. It is necessary to establish sustainable and well qualified urban living spaces for the public prepared for disaster. In other words, on one hand, disaster preparation activities have to be performed quickly and integrated with urban planning on the other hand, approaches on urban regeneration models have to be developed and application / implementation areas for these models have to be determined. By considering these findings, we have to determine the agenda of the new period in a right way. Especially, the earthquake expectation and the fact that building stock is not sound and strong enough necessitate the questioning of what prerequisites have to be in disaster focused urban regeneration planning. While urban regeneration activities, which have been realized in Istanbul recently is made up of singular projects implemented by the efforts of the local authorities, the efforts to associate preparation activities for the earthquake with urban planning has been limited. In this process, the efforts were made to find answers for the questions like what should urban regeneration be? What should it cover? What are the conditions and strategies special for Istanbul? and several conceptual confusions were experienced. This confusion or chaos will be removed with practical examples in the process. The steps taken to this effect is valuable and should light the way for national policies, they should be pioneer in this way. The aim of this article is to evaluate the toolkits for flagship regeneration projects based on earthquake and their applicability and to build up evidence based urban regeneration policies for future. In the article, after literature investigation on flagship urban regeneration projects, toolkits for flagship urban regeneration projects based on earthquake are examined. By testing the applicability of the toolkits for flagship urban transformation projects based on earthquake on case area with SWOT analysis method, important urban regeneration policies are developed for Istanbul. The article emphasizes the importance of urban regeneration policies which will create flagship development based on earthquake and submits the proof for urban regeneration by pilot area test. In the 2nd section following the introduction section of the article, it is emphasized the main components of an earthquake based urban regeneration project. In the third section, selection of case / sample area and its importance is stated in the context of methodology of the study. In the fourth section of the article, in the framework of key components of an earthquake based regeneration project, the applicability of earthquake based regeneration model is questioned / interrogated on the area taken as a case / sample in Istanbul and the components of regeneration project are evaluated. In Conclusion section, pilot project proofs based strategies and policies are developed in earthquake based regeneration model.