The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion

AYDIN, Kılıçoğlu Birsen; EREN, Zafer

The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion

Kılıçoğlu Birsen AYDIN, (Ondokuz Mayıs Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Samsun, Türkiye)

Zafer EREN (Ondokuz Mayıs Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Samsun, Türkiye)

Journal of Applied Biological Sciences

4 0

Yıl: 2007 Cilt: 1 Sayı: 1 Sayfa Aralığı: 51 - 56 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion

Öz:

Damage caused by free oxygen radicals is quite important in ischemia/reperfusion (I/R). Therefore, our study focuses on the effects of Aspirin and Vitamin E on the activity changes in erythrocyte radical scavenging enzymes in superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (Gpx) activities following liver ischemia/reperfusion in rats. Winstar albino male rats were divided into six groups as sham, isotonic saline solvent Aspirin, Vitamin E solvent corn oil injected control groups and Aspirin, Vitamin E and Aspirin+Vitamin E injected test groups. Rats subjected to ischemia were then grouped and exposed to reperfusion at the 0th, 2nd, 8th and 24th hours. After reperfusion, blood samples were taken via a dispossible injector from the heart at these hours and the enzyme activities were studied in erythrocyte fractions. Enzyme activity changes were seen during reperfusion periods, particularly the 2nd hour of reperfusion more striking than in ischemia period. When Aspirin and Vitamin E were given separately caused enzyme activity changes but these changes more remarkable when Aspirin and Vitamin E given together. Considering these results, Aspirin and Vitamin E may be suggested to prevent post-ischemic damage owing to their potential therapeutic effects.

Anahtar Kelime: rats ischaemia ischemia reperfusion enzyme activity erythrocytes glutathione peroxidase catalase aspirin oxidoreductases superoxide dismutase vitamin E

Konular: Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AYDIN K, EREN Z (2007). The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. , 51 - 56.
Chicago	AYDIN Kılıçoğlu Birsen,EREN Zafer The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. (2007): 51 - 56.
MLA	AYDIN Kılıçoğlu Birsen,EREN Zafer The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. , 2007, ss.51 - 56.
AMA	AYDIN K,EREN Z The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. . 2007; 51 - 56.
Vancouver	AYDIN K,EREN Z The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. . 2007; 51 - 56.
IEEE	AYDIN K,EREN Z "The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion." , ss.51 - 56, 2007.
ISNAD	AYDIN, Kılıçoğlu Birsen - EREN, Zafer. "The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion". (2007), 51-56.

APA	AYDIN K, EREN Z (2007). The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. Journal of Applied Biological Sciences, 1(1), 51 - 56.
Chicago	AYDIN Kılıçoğlu Birsen,EREN Zafer The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. Journal of Applied Biological Sciences 1, no.1 (2007): 51 - 56.
MLA	AYDIN Kılıçoğlu Birsen,EREN Zafer The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. Journal of Applied Biological Sciences, vol.1, no.1, 2007, ss.51 - 56.
AMA	AYDIN K,EREN Z The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. Journal of Applied Biological Sciences. 2007; 1(1): 51 - 56.
Vancouver	AYDIN K,EREN Z The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion. Journal of Applied Biological Sciences. 2007; 1(1): 51 - 56.
IEEE	AYDIN K,EREN Z "The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion." Journal of Applied Biological Sciences, 1, ss.51 - 56, 2007.
ISNAD	AYDIN, Kılıçoğlu Birsen - EREN, Zafer. "The efffects of Aspirin and Vitamin E on antioxidant enzymes of Rats during experimental liver Ischemia-Reperfusion". Journal of Applied Biological Sciences 1/1 (2007), 51-56.