Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient

AKAY, Olga Meltem; GULBAS, ZAFER; GÜNDÜZ, Eren; DURAK ARAS, BEYHAN

Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient

Eren GÜNDÜZ, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Eskişehir, Türkiye)

Olga Meltem AKAY, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Eskişehir, Türkiye)

BEYHAN DURAK ARAS, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Eskişehir, Türkiye)

Zafer GÜLBAŞ (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Eskişehir, Türkiye)

Turkish Journal of Hematology

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Yıl: 2007 Cilt: 24 Sayı: 2 Sayfa Aralığı: 85 - 87 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient

Öz:

Akut promiyelositik lösemili hastalarda tedaviye bağlı miyelodisplastik sendrom nadir bir olaydır ve prognozu kötüdür. Son dönemde allogeneik kök hücre naklinin etkili bir tedavi şekli olduğu bildirilmektedir. Biz de tam remisyondan 52 ay sonra miyelodisplastik sendrom gelişen akut promiyelositik lösemili genç bir hastayı sunduk. Hastaya allogeneik kök hücre nakli yapıldı ancak 5 ay sonra bifenotipik lösemi gözlendi. Bildiğimiz kadarıyla bu olgu tedaviye bağlı miyelodisplastik sendrom nedeniyle yapılan allogeneik periferik kök hücre nakli sonrası bifenotipik lösemi şeklinde relaps gelişen ilk olgudur.

Anahtar Kelime: Erişkin Nakil, homolog Seyir Lösemi, promiyelostik, akut Kadın Kök hücre nakli

Konular: Hematoloji

Aynı hastada gelişen akut promiyelositik lösemi sonrası miyelodisplastik sendrom ve kök hücre nakli sonrası bifenotipik lösemi

Öz:

Therapy-related myelodysplastic syndrome in patients with acute promyelocytic leukemia is a rare event and the prognosis is poor. Allogeneic bone marrow transplantation is recently being reported as an effective treatment. We present a young patient with acute promyelocytic leukemia who developed myelodysplastic syndrome 52 months after complete remission. She underwent allogeneic peripheral blood stem cell transplantation but relapsed with biphenotypic leukemia after five months. To our knowledge, this is the first case to relapse with acute biphenotypic leukemia after allogeneic peripheral stem cell transplantation for therapy-related myelodysplastic syndrome following acute promyelocytic leukemia.

Anahtar Kelime: Leukemia, Promyelocytic, Acute Female Stem Cell Transplantation Adult Transplantation, Homologous Prognosis

Konular: Hematoloji

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

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APA	GÜNDÜZ E, AKAY O, DURAK ARAS B, GULBAS Z (2007). Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. , 85 - 87.
Chicago	GÜNDÜZ Eren,AKAY Olga Meltem,DURAK ARAS BEYHAN,GULBAS ZAFER Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. (2007): 85 - 87.
MLA	GÜNDÜZ Eren,AKAY Olga Meltem,DURAK ARAS BEYHAN,GULBAS ZAFER Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. , 2007, ss.85 - 87.
AMA	GÜNDÜZ E,AKAY O,DURAK ARAS B,GULBAS Z Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. . 2007; 85 - 87.
Vancouver	GÜNDÜZ E,AKAY O,DURAK ARAS B,GULBAS Z Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. . 2007; 85 - 87.
IEEE	GÜNDÜZ E,AKAY O,DURAK ARAS B,GULBAS Z "Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient." , ss.85 - 87, 2007.
ISNAD	GÜNDÜZ, Eren vd. "Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient". (2007), 85-87.

APA	GÜNDÜZ E, AKAY O, DURAK ARAS B, GULBAS Z (2007). Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. Turkish Journal of Hematology, 24(2), 85 - 87.
Chicago	GÜNDÜZ Eren,AKAY Olga Meltem,DURAK ARAS BEYHAN,GULBAS ZAFER Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. Turkish Journal of Hematology 24, no.2 (2007): 85 - 87.
MLA	GÜNDÜZ Eren,AKAY Olga Meltem,DURAK ARAS BEYHAN,GULBAS ZAFER Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. Turkish Journal of Hematology, vol.24, no.2, 2007, ss.85 - 87.
AMA	GÜNDÜZ E,AKAY O,DURAK ARAS B,GULBAS Z Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. Turkish Journal of Hematology. 2007; 24(2): 85 - 87.
Vancouver	GÜNDÜZ E,AKAY O,DURAK ARAS B,GULBAS Z Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. Turkish Journal of Hematology. 2007; 24(2): 85 - 87.
IEEE	GÜNDÜZ E,AKAY O,DURAK ARAS B,GULBAS Z "Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient." Turkish Journal of Hematology, 24, ss.85 - 87, 2007.
ISNAD	GÜNDÜZ, Eren vd. "Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient". Turkish Journal of Hematology 24/2 (2007), 85-87.