TY  - JOUR
TI  - Synthesis and antimicrobial evaluation of novel di-triazoles and 4-arylidene amino 4,5 dihydro-1H-[1,2,4] triazole-5-one derivatives
AB  - A series of novel di-[3(thiophen-2-yl-methyl)-4,5-dihydro-1H-[1,2,4]triazole-5-one-4yl]n-alkanes (2a-h) were obtained by the reaction of N’-1-ethoxy-2-thiophen-2-yl-ethylydene hydrazino carboxylic acid ethyl ester (1) and diamines. Compound 3 was reacted with aldehydes and 4-(arylidene-amino)- 3-thiophen-2-yl-methyl-4,5-dihydro-1H-[1,2,4] triazole-5-ones (4, 5, and 8) with Schiff base character were synthesized. (4-(arylidene-amino)-5-oxo-3-thiophen-2-yl-methyl-4,5-dihydro-1H-[1,2,4]triazole- 1-yl)-acetic acid ethyl esters (6, 7, and 9) were obtained by the reaction of 4-(arylidene-amino)-3- thiophen-2-yl-methyl-4,5-dihydro-1H-[1,2,4]triazole-5-ones (4, 5, and 8) and ethyl bromoacetate. The structures of the new compounds were inferred through IR, $^1H/^{13}C$ NMR, elemental analyses, and mass spectral data. Compound 8i was characterized by IR, $^1H/^{13}C$ NMR, elemental analyses, mass, and X-ray spectral techniques. Geometry optimization of compounds 2a, 2c, 2f, 4, and 5 was achieved by computer using the AM1 method. Compounds 2f, 4, 5, 6, 7, 8i, and 9k showed good antifungal activity only against yeast fungi, while compound 2d showed antimicrobial activity against the bacteria Pseudomonas aeruginosa ATCC10145, Enterococcus faecalis ATCC29212 and the yeast fungi Candida albicans ATCC 60193 and Candida tropicalis ATCC 13803.
AU  - Alpay Karaoğlu, Şengül
AU  - DÜĞDÜ, Esra
AU  - SANCAK, KEMAL
AU  - ER, MUSTAFA
AU  - ÜNVER, YASEMİN
PY  - 2008
JO  - Turkish Journal of Chemistry
VL  - 32
IS  - 4
SN  - 1300-0527
SP  - 441
EP  - 455
DB  - TRDizin
UR  - http://search/yayin/detay/77645
ER  -