The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats
Yıl: 2008 Cilt: 14 Sayı: 2 Sayfa Aralığı: 96 - 102 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats
Öz: Bu çalışmanın amacı, sıçanlarda akut stres gastritis gelişmesinde düşük serum tiroit hormon düzeylerinin etkisini araştırmaktır. GEREÇ VE YÖNTEM Altmış erişkin Sprague-Dawley cinsi sıçan onarlı altı gruba ayrıldı: Kontrol grubu, cerrahi tiroidektomi grubu, stres grubu, cerrahi tiroidektomi + stres grubu, cerrahi tiroidektomi + T4 + stress grubu ve cerrahi tiroidektomi + T3 + stres grubu. Gastrik mukoza hasarının sayı ve büyüklüğü milimetrik asetat kağıdı kullanılarak 3,5 kez büyütülmüş fotoğraf üzerinde belirlendi. BULGULAR Sadece stres altında olan sıçanlar (grup III) ile karşılaştırıldığında cerrahi tiroidektomi + stres grubunda (grup IV) akut stres gastriti, belirgin olarak artmıştı (stres gastriti skorları; grup IV: 44, grup III: 16, p<0,001). Grup IV'teki sıçanlarla karşılaştırıldığında stres gastriti skorunun grup VFda belirgin olarak azaldığı gözlendi (stres gastriti skorları; grup VI: 10, grup IV: 44, p<0,001). SONUÇ Sıçanlarda düşük serum tiroit hormon düzeyleri stres gastritinin gelişmesini artırmakta ve bu etki, tiroit hormon replasman tedavisi ile önlenebilmektedir.
Anahtar Kelime: Konular:
Stres gastriti oluşumunda düşük tiroit hormon düzeylerinin etkisi: sıçanlar üzerinde deneysel bir çalışma
Öz: The aim of this study was to investigate the effect of low circulating thyroid hormone levels on the development of acute stress gastritis in rats. METHODS Sixty adult Sprague-Dawley rats were divided into six groups: Control group, surgically thyroidectomized group, stressed group, surgically thyroidectomized + stressed group, surgically thyroidectomized + T4 + stressed group, and surgically thyroidectomized + T3 + stressed group. Damage to the gastric mucosa was studied using millimetric acetate papers on photographs enlarged 3.5 times and the number and the size of the lesions was recorded. RESULTS Acute stress gastritis was significantly increased in stress + surgically thyroidectomized rats as compared to rats that were only put under stress (group III) (stress gastritis scores; group IV: 44, group İÜ: 16, p<0.001). The stress gastritis score in group VI was significantly decreased compared to rats in group IV (stress gastritis scores; group VI: 10, group IV: 44, p<0.001). CONCLUSION Low circulating thyroid hormone levels in rats increased the development of stress gastritis. This effect could be prevented by thyroid hormone replacement therapy.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | maralcan g, ERKOL M, ERKOL Z, Yanar F, PLEVIN R (2008). The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. , 96 - 102. |
Chicago | maralcan göktürk,ERKOL MEHMET HAYRI,ERKOL ZEHRA ZERRIN,Yanar Fatih,PLEVIN Rebecca The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. (2008): 96 - 102. |
MLA | maralcan göktürk,ERKOL MEHMET HAYRI,ERKOL ZEHRA ZERRIN,Yanar Fatih,PLEVIN Rebecca The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. , 2008, ss.96 - 102. |
AMA | maralcan g,ERKOL M,ERKOL Z,Yanar F,PLEVIN R The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. . 2008; 96 - 102. |
Vancouver | maralcan g,ERKOL M,ERKOL Z,Yanar F,PLEVIN R The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. . 2008; 96 - 102. |
IEEE | maralcan g,ERKOL M,ERKOL Z,Yanar F,PLEVIN R "The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats." , ss.96 - 102, 2008. |
ISNAD | maralcan, göktürk vd. "The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats". (2008), 96-102. |
APA | maralcan g, ERKOL M, ERKOL Z, Yanar F, PLEVIN R (2008). The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi, 14(2), 96 - 102. |
Chicago | maralcan göktürk,ERKOL MEHMET HAYRI,ERKOL ZEHRA ZERRIN,Yanar Fatih,PLEVIN Rebecca The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi 14, no.2 (2008): 96 - 102. |
MLA | maralcan göktürk,ERKOL MEHMET HAYRI,ERKOL ZEHRA ZERRIN,Yanar Fatih,PLEVIN Rebecca The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi, vol.14, no.2, 2008, ss.96 - 102. |
AMA | maralcan g,ERKOL M,ERKOL Z,Yanar F,PLEVIN R The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi. 2008; 14(2): 96 - 102. |
Vancouver | maralcan g,ERKOL M,ERKOL Z,Yanar F,PLEVIN R The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi. 2008; 14(2): 96 - 102. |
IEEE | maralcan g,ERKOL M,ERKOL Z,Yanar F,PLEVIN R "The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats." Ulusal Travma ve Acil Cerrahi Dergisi, 14, ss.96 - 102, 2008. |
ISNAD | maralcan, göktürk vd. "The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats". Ulusal Travma ve Acil Cerrahi Dergisi 14/2 (2008), 96-102. |