The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats

Yıl: 2008 Cilt: 14 Sayı: 2 Sayfa Aralığı: 96 - 102 Metin Dili: Türkçe
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The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats

Öz:
Bu çalışmanın amacı, sıçanlarda akut stres gastritis gelişmesinde düşük serum tiroit hormon düzeylerinin etkisini araştırmaktır. GEREÇ VE YÖNTEM Altmış erişkin Sprague-Dawley cinsi sıçan onarlı altı gruba ayrıldı: Kontrol grubu, cerrahi tiroidektomi grubu, stres grubu, cerrahi tiroidektomi + stres grubu, cerrahi tiroidektomi + T4 + stress grubu ve cerrahi tiroidektomi + T3 + stres grubu. Gastrik mukoza hasarının sayı ve büyüklüğü milimetrik asetat kağıdı kullanılarak 3,5 kez büyütülmüş fotoğraf üzerinde belirlendi. BULGULAR Sadece stres altında olan sıçanlar (grup III) ile karşılaştırıldığında cerrahi tiroidektomi + stres grubunda (grup IV) akut stres gastriti, belirgin olarak artmıştı (stres gastriti skorları; grup IV: 44, grup III: 16, p<0,001). Grup IV'teki sıçanlarla karşılaştırıldığında stres gastriti skorunun grup VFda belirgin olarak azaldığı gözlendi (stres gastriti skorları; grup VI: 10, grup IV: 44, p<0,001). SONUÇ Sıçanlarda düşük serum tiroit hormon düzeyleri stres gastritinin gelişmesini artırmakta ve bu etki, tiroit hormon replasman tedavisi ile önlenebilmektedir.
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Fen > Tıp > Acil Tıp
Fen > Tıp > Adli Tıp
Fen > Tıp > Yoğun Bakım, Tıp
Fen > Tıp > Ortopedi
Fen > Tıp > Cerrahi

Stres gastriti oluşumunda düşük tiroit hormon düzeylerinin etkisi: sıçanlar üzerinde deneysel bir çalışma

Öz:
The aim of this study was to investigate the effect of low circulating thyroid hormone levels on the development of acute stress gastritis in rats. METHODS Sixty adult Sprague-Dawley rats were divided into six groups: Control group, surgically thyroidectomized group, stressed group, surgically thyroidectomized + stressed group, surgically thyroidectomized + T4 + stressed group, and surgically thyroidectomized + T3 + stressed group. Damage to the gastric mucosa was studied using millimetric acetate papers on photographs enlarged 3.5 times and the number and the size of the lesions was recorded. RESULTS Acute stress gastritis was significantly increased in stress + surgically thyroidectomized rats as compared to rats that were only put under stress (group III) (stress gastritis scores; group IV: 44, group İÜ: 16, p<0.001). The stress gastritis score in group VI was significantly decreased compared to rats in group IV (stress gastritis scores; group VI: 10, group IV: 44, p<0.001). CONCLUSION Low circulating thyroid hormone levels in rats increased the development of stress gastritis. This effect could be prevented by thyroid hormone replacement therapy.
Anahtar Kelime:

Konular:
Fen > Tıp > Acil Tıp
Fen > Tıp > Adli Tıp
Fen > Tıp > Yoğun Bakım, Tıp
Fen > Tıp > Ortopedi
Fen > Tıp > Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA YANAR F, PLEVIN R, ERKOL H, ERKOL Z, MARALCAN G (2008). The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi, 14(2), 96 - 102.
Chicago YANAR Fatih,PLEVIN Rebecca,ERKOL Hayri,ERKOL Zerrin,MARALCAN Göktürk The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi 14, no.2 (2008): 96 - 102.
MLA YANAR Fatih,PLEVIN Rebecca,ERKOL Hayri,ERKOL Zerrin,MARALCAN Göktürk The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi, vol.14, no.2, 2008, ss.96 - 102.
AMA YANAR F,PLEVIN R,ERKOL H,ERKOL Z,MARALCAN G The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi. 2008; 14(2): 96 - 102.
Vancouver YANAR F,PLEVIN R,ERKOL H,ERKOL Z,MARALCAN G The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats. Ulusal Travma ve Acil Cerrahi Dergisi. 2008; 14(2): 96 - 102.
IEEE YANAR F,PLEVIN R,ERKOL H,ERKOL Z,MARALCAN G "The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats." Ulusal Travma ve Acil Cerrahi Dergisi, 14, ss.96 - 102, 2008.