The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock

SÖZÜER, Erdoğan Mütevelli; KÜÇÜK, Can; ÖZTÜRK, Figen; DURUKAN, POLAT; AKDUR, OKHAN; Özkan, Seda; AVŞAROĞULLARI, Levent; İKİZCELİ, İbrahim; MUHTAROĞLU, Sebahattin

The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock

Seda ÖZKAN, (Erciyes Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Kayseri, Türkiye)

İbrahim İKİZCELİ, (Erciyes Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Kayseri, Türkiye)

Erdoğan Mütevelli SÖZÜER, (Erciyes Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Kayseri, Türkiye)

Levent AVŞAROĞULLARI, (Erciyes Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Kayseri, Türkiye)

Figen ÖZTÜRK, (Erciyes Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Kayseri, Türkiye)

Sebahattin MUHTAROĞLU, (Erciyes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Okhan AKDUR, (Erciyes Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Kayseri, Türkiye)

Can KÜÇÜK, (Erciyes Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Kayseri, Türkiye)

Polat DURUKAN (Erciyes Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Kayseri, Türkiye)

Ulusal Travma ve Acil Cerrahi Dergisi

4 0

Yıl: 2008 Cilt: 14 Sayı: 4 Sayfa Aralığı: 277 - 283 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock

Öz:

AMAÇ: Hemorajik şok oluşturulan köpeklerde, pirasetamın şoka bağlı nitrik oksit düzeylerinde değişikliğe ve beyin dokusunda oluşan hipoksiye etkisinin olup olmadığı araştırıldı. GEREÇ-YÖNTEM: Denekler randomize olarak 10’ar köpekten oluşan dört gruba ayrıldı. Grup I, bir saatlik hemorajik şoka uğratıldı ve hemorajik şok sonrası tedavi verilmedi. Grup II, bir saatlik hemorajik şoka uğratıldı ve şok sonrası kan ile birlikte serum fizyolojik verildi. Grup III, bir saat hemorajik şoka uğratıldı ve şok sonrası kan ile birlikte intravenöz pirasetam verildi. Grup IV’e ise şok ve tedavi uygulanmadı. Deneyin başlangıcında, 60., 120. ve 180. dakikalarda nitrik oksit analizi için kan örnekleri alındı. Deneyin sonunda, histopatolojik inceleme için beyin doku örnekleri çıkarıldı. BULGULAR: Kan basıncı ve nabız değerlerindeki düzelmenin Grup III’deki deneklerde Grup II’deki deneklere göre daha iyi olduğu saptandı. Grup I’de nitrik oksit seviyelerinde yükselme olmasına rağmen, pirasetamla nitrik oksit seviyeleri arasında herhangi bir ilişki saptanmadı. Deneyin sonunda, Grup III’de hemorajik şoka bağlı gelişen beyin hasarındaki düzelmenin kontrol grubuna göre daha iyi olduğu saptandı. SONUÇ: Tedaviye eklenen pirasetam hemorajik şokta iskemik hasarı azaltabilir.

Anahtar Kelime: Zaman faktörleri Beyin Nitrik oksit Nöroprotektif ajanlar Kan basıncı Köpekler Hastalık modelleri, hayvan Eğri altı alan Varyans analizi Şok, kanama Pirasetam Erkek Hayvanlar Rastgele seçim İmmünohistokimya

Konular: Cerrahi

Hemorajik şok oluşturulan köpeklerde beyin hasarı ve serum nitrik oksit seviyelerine pirasetamın etkisi

Öz:

BACKGROUND: To demonstrate the effect of piracetam on changes in brain tissue and serum nitric oxide levels in dogs submitted to hemorrhagic shock. METHODS: The subjects were randomized into four subgroups each consisting of 10 dogs. Hemorrhagic shock was induced in Group I for 1 hour and no treatment was given to this group. Blood and saline solutions were administered to Group II following 1 hour hemorrhagic shock. Blood and piracetam were given to Group III following 1 hour shock. No shock was induced and no treatment was applied to Group IV. Blood samples were obtained at the onset of the experiment and at 60, 120 and 180 minutes for nitric oxide analysis. For histopathological examination, brain tissue samples were obtained at the end of the experiment. RESULTS: The observed improvement in blood pressure and pulse rates in Group III was more than in Group II. Nitric oxide levels were increased in Group I; however, no correlation between piracetam and nitric oxide levels was determined. It was seen that recovery in brain damage in Group III was greater than in the control group. CONCLUSION: Piracetam, added to the treatment, may decrease ischemic damage in hemorrhagic shock.

Anahtar Kelime: Shock, Hemorrhagic Piracetam Male Animals Random Allocation Immunohistochemistry Time Factors Brain Nitric Oxide Neuroprotective Agents Blood Pressure Dogs Disease Models, Animal Area Under Curve Analysis of Variance

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Özkan S, İKİZCELİ İ, SÖZÜER E, AVŞAROĞULLARI L, ÖZTÜRK F, MUHTAROĞLU S, AKDUR O, KÜÇÜK C, DURUKAN P (2008). The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. , 277 - 283.
Chicago	Özkan Seda,İKİZCELİ İbrahim,SÖZÜER Erdoğan Mütevelli,AVŞAROĞULLARI Levent,ÖZTÜRK Figen,MUHTAROĞLU Sebahattin,AKDUR OKHAN,KÜÇÜK Can,DURUKAN POLAT The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. (2008): 277 - 283.
MLA	Özkan Seda,İKİZCELİ İbrahim,SÖZÜER Erdoğan Mütevelli,AVŞAROĞULLARI Levent,ÖZTÜRK Figen,MUHTAROĞLU Sebahattin,AKDUR OKHAN,KÜÇÜK Can,DURUKAN POLAT The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. , 2008, ss.277 - 283.
AMA	Özkan S,İKİZCELİ İ,SÖZÜER E,AVŞAROĞULLARI L,ÖZTÜRK F,MUHTAROĞLU S,AKDUR O,KÜÇÜK C,DURUKAN P The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. . 2008; 277 - 283.
Vancouver	Özkan S,İKİZCELİ İ,SÖZÜER E,AVŞAROĞULLARI L,ÖZTÜRK F,MUHTAROĞLU S,AKDUR O,KÜÇÜK C,DURUKAN P The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. . 2008; 277 - 283.
IEEE	Özkan S,İKİZCELİ İ,SÖZÜER E,AVŞAROĞULLARI L,ÖZTÜRK F,MUHTAROĞLU S,AKDUR O,KÜÇÜK C,DURUKAN P "The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock." , ss.277 - 283, 2008.
ISNAD	Özkan, Seda vd. "The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock". (2008), 277-283.

APA	Özkan S, İKİZCELİ İ, SÖZÜER E, AVŞAROĞULLARI L, ÖZTÜRK F, MUHTAROĞLU S, AKDUR O, KÜÇÜK C, DURUKAN P (2008). The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. Ulusal Travma ve Acil Cerrahi Dergisi, 14(4), 277 - 283.
Chicago	Özkan Seda,İKİZCELİ İbrahim,SÖZÜER Erdoğan Mütevelli,AVŞAROĞULLARI Levent,ÖZTÜRK Figen,MUHTAROĞLU Sebahattin,AKDUR OKHAN,KÜÇÜK Can,DURUKAN POLAT The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. Ulusal Travma ve Acil Cerrahi Dergisi 14, no.4 (2008): 277 - 283.
MLA	Özkan Seda,İKİZCELİ İbrahim,SÖZÜER Erdoğan Mütevelli,AVŞAROĞULLARI Levent,ÖZTÜRK Figen,MUHTAROĞLU Sebahattin,AKDUR OKHAN,KÜÇÜK Can,DURUKAN POLAT The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. Ulusal Travma ve Acil Cerrahi Dergisi, vol.14, no.4, 2008, ss.277 - 283.
AMA	Özkan S,İKİZCELİ İ,SÖZÜER E,AVŞAROĞULLARI L,ÖZTÜRK F,MUHTAROĞLU S,AKDUR O,KÜÇÜK C,DURUKAN P The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. Ulusal Travma ve Acil Cerrahi Dergisi. 2008; 14(4): 277 - 283.
Vancouver	Özkan S,İKİZCELİ İ,SÖZÜER E,AVŞAROĞULLARI L,ÖZTÜRK F,MUHTAROĞLU S,AKDUR O,KÜÇÜK C,DURUKAN P The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock. Ulusal Travma ve Acil Cerrahi Dergisi. 2008; 14(4): 277 - 283.
IEEE	Özkan S,İKİZCELİ İ,SÖZÜER E,AVŞAROĞULLARI L,ÖZTÜRK F,MUHTAROĞLU S,AKDUR O,KÜÇÜK C,DURUKAN P "The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock." Ulusal Travma ve Acil Cerrahi Dergisi, 14, ss.277 - 283, 2008.
ISNAD	Özkan, Seda vd. "The effect of piracetam on brain damage and serum nitric oxide levels in dogs submitted to hemorrhagic shock". Ulusal Travma ve Acil Cerrahi Dergisi 14/4 (2008), 277-283.