Relationship between elevated levels of serum uric acid and saphenous vein graft disease

TAVİL, Yusuf; HIZAL, Fatma; AÇIKGÖZ, Sadri Kadri; TOPAL, Salih; ŞEN, Nihat; YALÇIN, Mehmet Rıdvan; TAŞOĞLU, İrfan

Relationship between elevated levels of serum uric acid and saphenous vein graft disease

Yusuf TAVİL, (Gazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Nihat ŞEN, (Gazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Fatma HIZAL, (Gazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Sadri Kadri AÇIKGÖZ, (Gazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

İrfan TAŞOĞLU, (Gazi Üniversitesi, Tıp Fakültesi, Kardiyovasküler Cerrahi Anabilim Dalı, Ankara, Türkiye)

Salih TOPAL, (Gazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Mehmet Rıdvan YALÇIN (Gazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Türk Kardiyoloji Derneği Arşivi

2 0

Yıl: 2008 Cilt: 36 Sayı: 1 Sayfa Aralığı: 14 - 18 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Relationship between elevated levels of serum uric acid and saphenous vein graft disease

Öz:

Amaç: Serum ürik asit (SÜA) yüksekliğinin koroner arter hastalığı ve kardiyovasküler ölümle ilişkisi birçok çalışmada gösterilmiştir. Bu çalışmada, koroner arter baypas ameliyatı geçiren hastalarda, uzun dönem safen ven grefti (SVG) açıklığının SÜA düzeyleri ile ilişkisi araştırıldı. Çalışma planı: Çalışmaya, en az bir adet SVG kullanılarak yapılan koroner arter baypas cerrahisinden ortalama 5.6 yıl sonra elektif koroner anjiyografi ile değerlendirilen 192 hasta (152 erkek, 40 kadın) alındı. Hastalar SVG açıklığının derecesine göre iki grupta değerlendirildi; ven greftinde %50 veya daha fazla darlık olması hemodinamik olarak önemli kabul edildi. Serum ürik asit düzeyleri enzimatik kolorimetrik yöntemle belirlendi. Bulgular: Safen ven greftleri 90 hastada (71 erkek, 19 kadın; ort. yaş 62±8) açık bulunurken, 102 hastada (81 erkek, 21 kadın; ort. yaş 62±10) darlık saptandı. Cerrahi ile anjiyografi arasındaki süre darlık saptanan grupta anlamlı derecede uzun bulundu (p<0.001). Greftin açık olduğu grupla karşılaştırıldığında, ortalama SÜA düzeyi darlık grubunda anlamlı derecede yüksek idi (4.9±1.2 mg/dl ve 5.8±1.4 mg/dl; p=0.02). Serum ürik asit düzeyleri, tek veya birden çok greftte darlık gelişen hastalar arasında anlamlı farklılık göstermedi (p=0.224). Çoklu regresyon analizinde, SVG hastalığının bağımsız belirleyicilerinin SÜA düzeyi (p<0.001), diyabetes mellitus (p=0.028) ve sigara içme (p=0.039) olduğu görüldü.Sonuç: Bulgularımız, koroner arter baypas ameliyatı geçiren hastalarda artmış SÜA düzeyi ile SVG hastalığı arasında anlamlı ilişki olduğunu göstermektedir. Bu durum hiperürisemi için erken tarama ve antiürisemik tedavi gerektiğini düşündürmektedir.

Anahtar Kelime: Koroner arter hastalığı Koroner anjiyografi Koroner arter köprüleme Safen ven Greft oklüzyonu, vasküler Hiperurisemi Testlerin kestirim değeri Ürik asit

Konular: Kalp ve Kalp Damar Sistemi

Yüksek serum ürik asit düzeyleri ile safen ven grefti hastalığı arasındaki ilişki

Öz:

Objectives: Several studies have shown an association between elevated serum uric acid (SUA) levels and coronary heart disease and cardiovascular mortality. We investigated the relationship between SUA levels and the patency of saphenous vein grafts (SVG) after coronary artery bypass graft (CABG) surgery. Study design: The study included 192 patients (152 men, 40 women) who underwent elective coronary angiography after a mean of 5.6 years following CABG surgery, which involved the use of at least one SVG. The patients were divided into two groups depending on the extent of SVG patency. Stenosis of 50% or greater within the SVG was accepted as hemodynamically significant. Serum uric acid levels were determined with the enzymatic colorimetric method. Results: Ninety patients (71 men, 19 women; mean age 62±8 years) were found to have patent SVG. Stenotic SVGs were detected in 102 patients (81 men, 21 women; mean age 62±10 years). The time interval between surgery and angiography was significantly longer in the stenotic group (p<0.001). Compared to patients without SVG disease, the mean SUA level was significantly higher in patients with SVG disease (4.9±1.2 mg/dl vs 5.8±1.4 mg/dl; p=0.02). Serum uric acid levels were similar in patients having stenosis in a single vein graft or multiple vein grafts (p=0.224). In multiple regression analysis, SVG disease was independently associated with SUA (p<0.001), diabetes mellitus (p=0.028), and smoking (p=0.039).Conclusion: Our results show that there is a significant association between increased SUA levels and SVG disease in patients undergoing CABG, which may justify the need for early screening for hyperuricemia and antiuricemic treatment.

Anahtar Kelime: Predictive Value of Tests Uric Acid Coronary Artery Disease Coronary Angiography Coronary Artery Bypass Saphenous Vein Graft Occlusion, Vascular Hyperuricemia

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TAVİL Y, ŞEN N, HIZAL F, AÇIKGÖZ S, TAŞOĞLU İ, TOPAL S, YALÇIN M (2008). Relationship between elevated levels of serum uric acid and saphenous vein graft disease. , 14 - 18.
Chicago	TAVİL Yusuf,ŞEN Nihat,HIZAL Fatma,AÇIKGÖZ Sadri Kadri,TAŞOĞLU İrfan,TOPAL Salih,YALÇIN Mehmet Rıdvan Relationship between elevated levels of serum uric acid and saphenous vein graft disease. (2008): 14 - 18.
MLA	TAVİL Yusuf,ŞEN Nihat,HIZAL Fatma,AÇIKGÖZ Sadri Kadri,TAŞOĞLU İrfan,TOPAL Salih,YALÇIN Mehmet Rıdvan Relationship between elevated levels of serum uric acid and saphenous vein graft disease. , 2008, ss.14 - 18.
AMA	TAVİL Y,ŞEN N,HIZAL F,AÇIKGÖZ S,TAŞOĞLU İ,TOPAL S,YALÇIN M Relationship between elevated levels of serum uric acid and saphenous vein graft disease. . 2008; 14 - 18.
Vancouver	TAVİL Y,ŞEN N,HIZAL F,AÇIKGÖZ S,TAŞOĞLU İ,TOPAL S,YALÇIN M Relationship between elevated levels of serum uric acid and saphenous vein graft disease. . 2008; 14 - 18.
IEEE	TAVİL Y,ŞEN N,HIZAL F,AÇIKGÖZ S,TAŞOĞLU İ,TOPAL S,YALÇIN M "Relationship between elevated levels of serum uric acid and saphenous vein graft disease." , ss.14 - 18, 2008.
ISNAD	TAVİL, Yusuf vd. "Relationship between elevated levels of serum uric acid and saphenous vein graft disease". (2008), 14-18.

APA	TAVİL Y, ŞEN N, HIZAL F, AÇIKGÖZ S, TAŞOĞLU İ, TOPAL S, YALÇIN M (2008). Relationship between elevated levels of serum uric acid and saphenous vein graft disease. Türk Kardiyoloji Derneği Arşivi, 36(1), 14 - 18.
Chicago	TAVİL Yusuf,ŞEN Nihat,HIZAL Fatma,AÇIKGÖZ Sadri Kadri,TAŞOĞLU İrfan,TOPAL Salih,YALÇIN Mehmet Rıdvan Relationship between elevated levels of serum uric acid and saphenous vein graft disease. Türk Kardiyoloji Derneği Arşivi 36, no.1 (2008): 14 - 18.
MLA	TAVİL Yusuf,ŞEN Nihat,HIZAL Fatma,AÇIKGÖZ Sadri Kadri,TAŞOĞLU İrfan,TOPAL Salih,YALÇIN Mehmet Rıdvan Relationship between elevated levels of serum uric acid and saphenous vein graft disease. Türk Kardiyoloji Derneği Arşivi, vol.36, no.1, 2008, ss.14 - 18.
AMA	TAVİL Y,ŞEN N,HIZAL F,AÇIKGÖZ S,TAŞOĞLU İ,TOPAL S,YALÇIN M Relationship between elevated levels of serum uric acid and saphenous vein graft disease. Türk Kardiyoloji Derneği Arşivi. 2008; 36(1): 14 - 18.
Vancouver	TAVİL Y,ŞEN N,HIZAL F,AÇIKGÖZ S,TAŞOĞLU İ,TOPAL S,YALÇIN M Relationship between elevated levels of serum uric acid and saphenous vein graft disease. Türk Kardiyoloji Derneği Arşivi. 2008; 36(1): 14 - 18.
IEEE	TAVİL Y,ŞEN N,HIZAL F,AÇIKGÖZ S,TAŞOĞLU İ,TOPAL S,YALÇIN M "Relationship between elevated levels of serum uric acid and saphenous vein graft disease." Türk Kardiyoloji Derneği Arşivi, 36, ss.14 - 18, 2008.
ISNAD	TAVİL, Yusuf vd. "Relationship between elevated levels of serum uric acid and saphenous vein graft disease". Türk Kardiyoloji Derneği Arşivi 36/1 (2008), 14-18.