Yıl: 2008 Cilt: 32 Sayı: 4 Sayfa Aralığı: 259 - 263 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine

Öz:
Equisetum telmateia bitkisinin topraküstü kısımları Türkiye’de halk arasında mide ağrısı ve peptik ülser dahil olmak üzere çeşitli hastalıkların tedavisinde halk ilacı olarak kullanılmaktadır. E. telmateia’nın iddia edilen antiülserojenik etkisini incelemek için toprak üstü kısımlarının sulu ve metanollü ekstreleri hazırlanmış ve sıçanlarda etanolle oluşturulan gastrik ülser modelinde incelenmiştir. Farmakolojik deneyler materyalin metanollü ve sulu ekstrelerinin her ikisinin de oral yolla uygulandığında bu ülser modeli üzerinde midede anlamlı bir koruma sağladığını (ülser önleme oranı sırasıyla %77,9 ve %100) göstermiştir (P < 0,001). Her iki ekstrenin de aktif olması nedeniyle, materyalin %80 etanol ile ekstre edilmesi tercih edilmiş; ardından %80 etanol ekstresi kloroform ve suyla doyurulmuş n-bütanol ile daha ileri bir ayırıma tabi tutularak, kloroform, n-bütanol ve kalan su ekstreleri elde edilmiştir. %80 etanol ekstresi ve sıvı-sıvı ekstraksiyonla elde edilen ekstreler aynı in vivo deneysel ülser modeline uygulanmıştır. Tüm ekstreler bu model üzerinde istatistiksel olarak kuvvetli antiülserojenik etki göstermiş (P < 0.001), ancak en belirgin etki kalan sulu ekstrede görülmüştür (ülser önleme oranı %98,2). Sonuç olarak bu çalışmayla E. telmateia’nın halk arasında peptik ülser üzerindeki kullanımı, sıçanlarda etanolle oluşturulan deneysel gastrik ülser modeli kullanılarak doğrulanmıştır.
Anahtar Kelime: ülser tıbbi bitkiler mide-bağırsak hastalıkları bitki özütü Equisetum telmateia peptik ülser

Konular: Biyoloji

Türkiye'de halk ilacı olarak kullanılan Equisetum telmateia Ehrh. bitkisinin ekstrelerinin ın vivo antiülserojenik aktivitesi

Öz:
The aerial part of Equisetum telmateia Ehrh. is used against various conditions including stomachache and peptic ulcer in Turkish folk medicine. In order to prove the claimed anti-ulcerogenic potential of the plant, aqueous and methanol extracts were prepared from aerial parts of E. telmateia and investigated for their anti-ulcerogenic effect on ethanol-induced gastric ulcer model in rats. Pharmacological experiments clearly demonstrated that the oral administration of both methanol and aqueous extracts of Equisetum telmateia Ehrh. plant showed significant stomach protection (77.9% and 100% ulcer inhibition, respectively) against the applied model of ulcerogenesis (P < 0.001). Since both extracts were found significantly active, 80% ethanol was preferred for the extraction of the plant material and this crude methanolic extract was further fractionated by successive solvent extractions with chloroform and H2O saturated n-BuOH to obtain the chloroform and n-BuOH extracts as well as the remaining aqueous extract. The 80% ethanol extract and the solvent extracts were then submitted to pharmacological assay using the same in vivo experimental ulcer model. All the extracts statistically showed potent anti-ulcerogenic effect on this model (P < 0.001). However, the remaining aqueous extract was found prominent (98.2% ulcer inhibition). Consequently, folkloric utilization of E. telmateia on peptic ulcer has been confirmed in the present study by using ethanol-induced experimental ulcer model in rats.
Anahtar Kelime: Equisetum telmateia peptic ulcers ulcers medicinal plants gastrointestinal diseases plant extracts

Konular: Biyoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA GÜRBÜZ İ, Yesilada E (2008). In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. , 259 - 263.
Chicago GÜRBÜZ İLHAN,Yesilada Erdem In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. (2008): 259 - 263.
MLA GÜRBÜZ İLHAN,Yesilada Erdem In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. , 2008, ss.259 - 263.
AMA GÜRBÜZ İ,Yesilada E In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. . 2008; 259 - 263.
Vancouver GÜRBÜZ İ,Yesilada E In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. . 2008; 259 - 263.
IEEE GÜRBÜZ İ,Yesilada E "In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine." , ss.259 - 263, 2008.
ISNAD GÜRBÜZ, İLHAN - Yesilada, Erdem. "In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine". (2008), 259-263.
APA GÜRBÜZ İ, Yesilada E (2008). In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. Turkish Journal of Biology, 32(4), 259 - 263.
Chicago GÜRBÜZ İLHAN,Yesilada Erdem In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. Turkish Journal of Biology 32, no.4 (2008): 259 - 263.
MLA GÜRBÜZ İLHAN,Yesilada Erdem In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. Turkish Journal of Biology, vol.32, no.4, 2008, ss.259 - 263.
AMA GÜRBÜZ İ,Yesilada E In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. Turkish Journal of Biology. 2008; 32(4): 259 - 263.
Vancouver GÜRBÜZ İ,Yesilada E In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine. Turkish Journal of Biology. 2008; 32(4): 259 - 263.
IEEE GÜRBÜZ İ,Yesilada E "In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine." Turkish Journal of Biology, 32, ss.259 - 263, 2008.
ISNAD GÜRBÜZ, İLHAN - Yesilada, Erdem. "In vivo anti-ulceroggenic activity of Equisetum telmateia Ehrh. extracts used in Turkish folk medicine". Turkish Journal of Biology 32/4 (2008), 259-263.