Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity

DEMİRBAĞ, ZİHNİ; ÜÇÜNCÜ, OSMAN; YAYLI, Nuran; YAYLI, Nurettin; DEMİR, Emine

Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity

Nuran YAYLI, (Karadeniz Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Trabzon, Türkiye)

Osman ÜÇÜNCÜ, (Karadeniz Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Trabzon, Türkiye)

Nurettin YAYLI, (Karadeniz Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Trabzon, Türkiye)

Emine DEMİR, (Karadeniz Teknik Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Trabzon, Türkiye)

Zihni DEMİRBAĞ (Karadeniz Teknik Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Trabzon, Türkiye)

Turkish Journal of Chemistry

1 0

Yıl: 2008 Cilt: 32 Sayı: 6 Sayfa Aralığı: 785 - 795 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity

Öz:

1,4'-Diazaflavone pigment (2) was synthesized by a simple environmentally friendly microwave-assisted one-pot method for the cyclization of 2'-amino (E)-4''-aza-chalcone (1) under solventless conditions using K-10 clay. In addition, 10 new N-alkyl $(C_{5-12,14-15})$ substituted 1,4'-diazaflavonium bromide pigments (3-12) were prepared from compound 2 or directly from compound 1, with corresponding alkyl halides in acetonitrile under reflux. The anti-microbial activity of compounds 1-12 was tested. The N-alkyl substituted 1,4'-diazaflavonium bromides (3-12) showed good antimicrobial activity against the gram-positive bacteria tested with minimal bactericidal concentration (MBC) values for the reference antibiotic kanamycin. The optimum length of the alkyl chain for better and broader activity was 6-10 carbon atoms in the series of compounds (3-12).

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YAYLI N, ÜÇÜNCÜ O, YAYLI N, DEMİR E, DEMİRBAĞ Z (2008). Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. , 785 - 795.
Chicago	YAYLI Nuran,ÜÇÜNCÜ OSMAN,YAYLI Nurettin,DEMİR Emine,DEMİRBAĞ ZİHNİ Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. (2008): 785 - 795.
MLA	YAYLI Nuran,ÜÇÜNCÜ OSMAN,YAYLI Nurettin,DEMİR Emine,DEMİRBAĞ ZİHNİ Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. , 2008, ss.785 - 795.
AMA	YAYLI N,ÜÇÜNCÜ O,YAYLI N,DEMİR E,DEMİRBAĞ Z Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. . 2008; 785 - 795.
Vancouver	YAYLI N,ÜÇÜNCÜ O,YAYLI N,DEMİR E,DEMİRBAĞ Z Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. . 2008; 785 - 795.
IEEE	YAYLI N,ÜÇÜNCÜ O,YAYLI N,DEMİR E,DEMİRBAĞ Z "Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity." , ss.785 - 795, 2008.
ISNAD	YAYLI, Nuran vd. "Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity". (2008), 785-795.

APA	YAYLI N, ÜÇÜNCÜ O, YAYLI N, DEMİR E, DEMİRBAĞ Z (2008). Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. Turkish Journal of Chemistry, 32(6), 785 - 795.
Chicago	YAYLI Nuran,ÜÇÜNCÜ OSMAN,YAYLI Nurettin,DEMİR Emine,DEMİRBAĞ ZİHNİ Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. Turkish Journal of Chemistry 32, no.6 (2008): 785 - 795.
MLA	YAYLI Nuran,ÜÇÜNCÜ OSMAN,YAYLI Nurettin,DEMİR Emine,DEMİRBAĞ ZİHNİ Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. Turkish Journal of Chemistry, vol.32, no.6, 2008, ss.785 - 795.
AMA	YAYLI N,ÜÇÜNCÜ O,YAYLI N,DEMİR E,DEMİRBAĞ Z Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. Turkish Journal of Chemistry. 2008; 32(6): 785 - 795.
Vancouver	YAYLI N,ÜÇÜNCÜ O,YAYLI N,DEMİR E,DEMİRBAĞ Z Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity. Turkish Journal of Chemistry. 2008; 32(6): 785 - 795.
IEEE	YAYLI N,ÜÇÜNCÜ O,YAYLI N,DEMİR E,DEMİRBAĞ Z "Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity." Turkish Journal of Chemistry, 32, ss.785 - 795, 2008.
ISNAD	YAYLI, Nuran vd. "Microwave-assisted synthesis of 1,4'-diazaflavone and N-alkyl derivative pigments with anti-microbial activity". Turkish Journal of Chemistry 32/6 (2008), 785-795.