Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis

DURSUN, Engin; Dagli, Muharrem; Aydın, Emine; Korkmaz, Hakan; ORTAPAMUK, Hülya; Eryılmaz, Adil; SAYLAM, Güleser

Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis

Emine AYDIN, (SB Ankara Numune Eğitim ve Araştırma Hastanesi, 3. Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Hülya ORTAPAMUK, (Sağlık Bakanlığı, Ankara Numune Eğitim ve Araştırma Hastanesi, Ankara, Türkiye)

Hakan KORKMAZ, (SB Ankara Numune Eğitim ve Araştırma Hastanesi, 3. Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Engin DURSUN, (SB Ankara Numune Eğitim ve Araştırma Hastanesi, 3. Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Adil ERYILMAZ, (SB Ankara Numune Eğitim ve Araştırma Hastanesi, 3. Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Güleser SAYLAM, (SB Ankara Numune Eğitim ve Araştırma Hastanesi, 3. Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Muharrem DAĞLI (SB Ankara Numune Eğitim ve Araştırma Hastanesi, 3. Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2008 Cilt: 38 Sayı: 5 Sayfa Aralığı: 465 - 470 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis

Öz:

Amaç: Düşük doz uzun süreli oral makrolid tedavisinin sinonazal polipoziste etkinliğini belirlemek. Çalışma, sinonazal polipozisli ve cerrahi hikayesi olmayan bir grup hastada prospektif olarak planmıştır. Yöntem ve Gereç: On hastaya sekiz hafta boyunca günlük 150 mg roksitromisin verilmiştir. Tüm hastalara mukosiliar aktivitenin Tc-99m rinosintigrafik değerlendirilmesi ve tedavi öncesi ve sonrası endoskopik değerlendirme yapıldı. Tedaviye yanıt, rinosintigrafik ve endoskopik iyileşme ile değerlendirildi. Bulgular: On hastanın 7’si erkek ve 3’ü bayandı. Ortalama yaş 46 (27-74) idi. Tedaviyi takiben mukosilier transport zamanı anlamlı derecede düşmüş (P < 0.05) ve polipler klinik olarak küçülmüştür (P < 0.05). Sonuç: Düşük doz uzun süreli oral makrolid tedavisi sinonazal polipozisin tedavisinde etkilidir. Makrolidlerin, sinonazal polipozis tedavisinde bir alternatif olarak veya steroidlerle bir arada kullanımı düşünülebilir.

Anahtar Kelime: İlaç uygulama, oral Nazal polipler İleriye dönük çalışma Makrolidler Polipler

Konular: Cerrahi

Sinonazal polipozis tedavisinde oral makrolidlerin yerinin klinik ve rinosintigrafik olarak değerlendirilmesi

Öz:

Aim: To document the efficacy of low-dose long-term oral macrolide treatment in the management of sinonasal polyposis. The study was designed prospectively in a group of patients with sinonasal polyposis and negative history of surgery. Materials and Methods: Ten patients were administered roxithromycin (RXM) 150 mg/day single oral dose for eight weeks. All patients underwent Tc-99m rhinoscintigraphic evaluation of mucociliary activity and endoscopic evaluation before and after the treatments. Response to treatment, in terms of rhinoscintigraphic and endoscopic improvement, was assessed. Results: Of the 10 patients, 7 were male and 3 female, with an average age of 46 years (27-74). Following treatment, mucociliary transport time was significantly reduced (P < 0.05) and the polyps were clinically shrunk (P < 0.05). Conclusions: It was determined that low-dose long-term oral macrolide treatment was effective in the management of sinonasal polyposis. Macrolides can be considered, as an alternative to or in conjunction with steroids, in the management of sinonasal polyposis.

Anahtar Kelime: Macrolides Polyps Administration, Oral Nasal Polyps Prospective Studies

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Aydın E, ORTAPAMUK H, Korkmaz H, DURSUN E, Eryılmaz A, SAYLAM G, Dagli M (2008). Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. , 465 - 470.
Chicago	Aydın Emine,ORTAPAMUK Hülya,Korkmaz Hakan,DURSUN Engin,Eryılmaz Adil,SAYLAM Güleser,Dagli Muharrem Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. (2008): 465 - 470.
MLA	Aydın Emine,ORTAPAMUK Hülya,Korkmaz Hakan,DURSUN Engin,Eryılmaz Adil,SAYLAM Güleser,Dagli Muharrem Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. , 2008, ss.465 - 470.
AMA	Aydın E,ORTAPAMUK H,Korkmaz H,DURSUN E,Eryılmaz A,SAYLAM G,Dagli M Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. . 2008; 465 - 470.
Vancouver	Aydın E,ORTAPAMUK H,Korkmaz H,DURSUN E,Eryılmaz A,SAYLAM G,Dagli M Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. . 2008; 465 - 470.
IEEE	Aydın E,ORTAPAMUK H,Korkmaz H,DURSUN E,Eryılmaz A,SAYLAM G,Dagli M "Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis." , ss.465 - 470, 2008.
ISNAD	Aydın, Emine vd. "Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis". (2008), 465-470.

APA	Aydın E, ORTAPAMUK H, Korkmaz H, DURSUN E, Eryılmaz A, SAYLAM G, Dagli M (2008). Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. Turkish Journal of Medical Sciences, 38(5), 465 - 470.
Chicago	Aydın Emine,ORTAPAMUK Hülya,Korkmaz Hakan,DURSUN Engin,Eryılmaz Adil,SAYLAM Güleser,Dagli Muharrem Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. Turkish Journal of Medical Sciences 38, no.5 (2008): 465 - 470.
MLA	Aydın Emine,ORTAPAMUK Hülya,Korkmaz Hakan,DURSUN Engin,Eryılmaz Adil,SAYLAM Güleser,Dagli Muharrem Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. Turkish Journal of Medical Sciences, vol.38, no.5, 2008, ss.465 - 470.
AMA	Aydın E,ORTAPAMUK H,Korkmaz H,DURSUN E,Eryılmaz A,SAYLAM G,Dagli M Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. Turkish Journal of Medical Sciences. 2008; 38(5): 465 - 470.
Vancouver	Aydın E,ORTAPAMUK H,Korkmaz H,DURSUN E,Eryılmaz A,SAYLAM G,Dagli M Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis. Turkish Journal of Medical Sciences. 2008; 38(5): 465 - 470.
IEEE	Aydın E,ORTAPAMUK H,Korkmaz H,DURSUN E,Eryılmaz A,SAYLAM G,Dagli M "Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis." Turkish Journal of Medical Sciences, 38, ss.465 - 470, 2008.
ISNAD	Aydın, Emine vd. "Clinical and rhinoscintigraphic evaluation of oral macrolides in the management of sinonasal polyposis". Turkish Journal of Medical Sciences 38/5 (2008), 465-470.