Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?

KUZU, ISINSU; KANKAYA, Duygu; KAYGUSUZ, GULSAH; Kiremitci, Saba; gençtürk, zeynep

Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?

Gülşah KAYGUSUZ, (Ankara Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Ankara, Türkiye)

Işınsu KUZU, (Ankara Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Ankara, Türkiye)

SABA KİREMİTCİ, (Ankara Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Ankara, Türkiye)

Duygu KANKAYA, (Ankara Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Ankara, Türkiye)

Zeynep BIYIKLI (Ankara Üniversitesi, Tıp Fakültesi, Bioistatistik Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

1 1

Yıl: 2008 Cilt: 38 Sayı: 6 Sayfa Aralığı: 511 - 517 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?

Öz:

Amaç: Biz bu çalışmada, geniş bir Hodgkin ve non-Hodgkin lenfoma serisinde CD117 ekspresyonunu değerlendirmeyi; CD117, IRF4/MUM1 ve CD38 ekspresyon patternleri arasındaki ilişkiyi araştırmayı amaçladık. Yöntem ve Gereç: Toplam 237 lenfoma vakası seçildi ve bu vakalardan 6 adet doku mikroarray paraffin bloğu hazırlandı. CD117, IRF4/MUM1 ve CD38 antikorları kullanılarak immunohistokimyasal inceleme yapıldı. Bulgular: CD117 ve IRF4/MUM1 ekspresyonu bir grup düşük ve yüksek dereceli B hücreli lenfomalar yanında; T hücreli lenfomalar ve Hodgkin lenfomalarda da gözlendi . CD38 pozitifliği, myeloma vakaları yanında diffüz büyük B hücreli lenfoma’ların yalnızca % 1’inde ve prekürsör B lenfoblastik lenfoma’ların % 66’ında görüldü. CD117 ekpresyonu, IRF4/MUM1 ekpresyonu ile korele bulunmadı (P > 0.05). CD38 pozitif 3 vakanın 2’sinde CD117 pozitif bulundu. Sonuç: Bu bulgular, CD117 ekspresyonunun bir grup T veya B hücreli lenfoid neoplazmlarda ve plazma hücreli myelomalarda görülebileceğini düşündürmektedir. Lenfomalarda, CD117 ekspresyonu ve plazma hücre diferansiasyonu belirleyicileri arasında bir ilişki bulunmamıştır.

Anahtar Kelime: Hücre farklılaşması Antijenler, CD38 Proto-onkojen protein c-kit Lenfom interferon düzenleyici faktör-4 İnterferon düzenleyici factör

Konular: Cerrahi

Lenfoid neoplazmlarda CD117 ekpresyonu, plazma hücre diferansiasyonu, IRF4/MUM1 ve CD38 ekpresyonları ile ilişkili midir?

Öz:

Aim: In this study, we aimed to assess the expression of CD117 in a large series of both Hodgkin’s and non- Hodgkin’s lymphoma, and to investigate the association between the expression patterns of CD117, IRF4/MUM1, and CD38. Materials and Methods: A total of 237 lymphoma cases were selected and examined within six tissue microarray paraffin blocks. Immunohistochemistry was performed using antibodies against CD117, IRF4/MUM1 and CD38. Results: CD117 and IRF4/MUM1 immunoreactivity were seen in a subset of high-grade and low-grade B-cell lymphomas, as well as T-cell lymphomas and classical type Hodgkin’s lymphomas. CD38 positivity was only detected in 1% of diffuse large B-cell lymphoma and 66% of precursor B-lymphoblastic lymphoma, in addition to myeloma cases. CD117 expression was not correlated with IRF4/MUM1 expression (P > 0.05). Two of three CD38- positive cases were positive for CD117. Conclusions: These results suggest that CD117 expression can be seen in a subset of T- or B- cell lymphoid neoplasms and plasma cell myelomas. It seems that there is no relation between the expression of CD117 and plasma cell differentiation markers in lymphomas.

Anahtar Kelime: Interferon Regulatory Factors Cell Differentiation Antigens, CD38 Proto-Oncogene Proteins c-kit Lymphoma interferon regulatory factor-4

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KAYGUSUZ G, KUZU I, Kiremitci S, KANKAYA D, gençtürk z (2008). Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. , 511 - 517.
Chicago	KAYGUSUZ GULSAH,KUZU ISINSU,Kiremitci Saba,KANKAYA Duygu,gençtürk zeynep Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. (2008): 511 - 517.
MLA	KAYGUSUZ GULSAH,KUZU ISINSU,Kiremitci Saba,KANKAYA Duygu,gençtürk zeynep Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. , 2008, ss.511 - 517.
AMA	KAYGUSUZ G,KUZU I,Kiremitci S,KANKAYA D,gençtürk z Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. . 2008; 511 - 517.
Vancouver	KAYGUSUZ G,KUZU I,Kiremitci S,KANKAYA D,gençtürk z Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. . 2008; 511 - 517.
IEEE	KAYGUSUZ G,KUZU I,Kiremitci S,KANKAYA D,gençtürk z "Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?." , ss.511 - 517, 2008.
ISNAD	KAYGUSUZ, GULSAH vd. "Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?". (2008), 511-517.

APA	KAYGUSUZ G, KUZU I, Kiremitci S, KANKAYA D, gençtürk z (2008). Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. Turkish Journal of Medical Sciences, 38(6), 511 - 517.
Chicago	KAYGUSUZ GULSAH,KUZU ISINSU,Kiremitci Saba,KANKAYA Duygu,gençtürk zeynep Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. Turkish Journal of Medical Sciences 38, no.6 (2008): 511 - 517.
MLA	KAYGUSUZ GULSAH,KUZU ISINSU,Kiremitci Saba,KANKAYA Duygu,gençtürk zeynep Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. Turkish Journal of Medical Sciences, vol.38, no.6, 2008, ss.511 - 517.
AMA	KAYGUSUZ G,KUZU I,Kiremitci S,KANKAYA D,gençtürk z Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. Turkish Journal of Medical Sciences. 2008; 38(6): 511 - 517.
Vancouver	KAYGUSUZ G,KUZU I,Kiremitci S,KANKAYA D,gençtürk z Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?. Turkish Journal of Medical Sciences. 2008; 38(6): 511 - 517.
IEEE	KAYGUSUZ G,KUZU I,Kiremitci S,KANKAYA D,gençtürk z "Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?." Turkish Journal of Medical Sciences, 38, ss.511 - 517, 2008.
ISNAD	KAYGUSUZ, GULSAH vd. "Is CD117 expression related with plasma cell differentiation, IRF4/MUM1 and CD38 expressions in lymphoid neoplasms?". Turkish Journal of Medical Sciences 38/6 (2008), 511-517.