Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes

AYTEKİN, Vedat; GÜLBARAN, Murat; CİVAN, Murat; ERDOĞMUŞ, Onur; Görmez, Selçuk; DEMİROĞLU, Cemşid; ÇATAKOĞLU, Alp Burak; ERDİM, Refik

Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes

Selçuk GÖRMEZ, (Florence Nightingale Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Refik ERDİM, (Florence Nightingale Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Onur ERDOĞMUŞ, (Florence Nightingale Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Murat CİVAN, (İstanbul Bilim Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Alp Burak ÇATAKOĞLU, (Florence Nightingale Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Murat GÜLBARAN, (İstanbul Bilim Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Cemşid DEMİROĞLU, (Florence Nightingale Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Vedat AYTEKİN (İstanbul Bilim Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Anadolu Kardiyoloji Dergisi

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Yıl: 2008 Cilt: 8 Sayı: 6 Sayfa Aralığı: 431 - 436 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes

Öz:

Amaç: Bu çalışmada amacımız günlük pratikte paklitaksel salınımlı (PSS) ve sirolimus salınımlı (SSS) stentler ile tedavi edilen safen ven greft (SVG) lezyonlu hastaları kısa ve uzun dönem klinik sonuçlar açısından karşılaştırmaktır. Yöntemler: Merkezimizde Ağustos 2002 ile Eylül 2006 tarihleri arasında SVG lezyonu için perkütan koroner girişim ile PSS veya SSS uygulanmış olan toplam 71 hasta retrospektif olarak değerlendirildi. Hastane içi, 30. gün, 6. ay ve 1. yıl klinik sonuçları açısından PSS uygulanan 46 hasta (PSS grubu), SSS uygulanan 25 hasta (SSS grubu) ile karşılaştırıldı. İstatistiksel değerlendirmede Ki-Kare, “Fisher exact” ve bağımsız örneklem t testleri kullanıldı. Sağkalım analizi Kaplan-Meier yöntemi ve log-rank testi ile yapıldı.Bulgular: Temel klinik özellikler her iki grupta da SSS grubundaki hastaların yaş ortalamasının daha düşük olması dışında benzerdi. Lezyon ve işlem özellikleri açısından her iki grup arasında istatistiksel olarak anlamlı bir fark bulunmadı. Girişim sonrası 30. gün, 6. ay ve 1. yılda tüm klinik sonuçlar her iki grupta da benzerdi. Erken stent trombozu PSS grubundaki 1 hastada (%2.2) saptandı (p=0.65). Geç stent trombozu her iki grupta da görülmedi. Birinci yılda majör istenmeyen kardiyak olay oranı PSS grubunda %8.7, SSS grubunda %16 idi (p=0.44).Sonuç: Safen ven greft lezyonlarının tedavisinde paklitaksel ve sirolimus salınımlı stentlerin kısa ve uzun dönem klinik sonuçları birbirlerine benzerdir. Çalışmamızda elde ettiğimiz bulgular, her iki ilaç salınımlı stentin de SVG lezyonu bulunan hastaların tedavisinde etkin ve güvenli olduğunu göstermektedir.

Anahtar Kelime: Anjioplasti, balon, koroner Kaplan-Meier tahmini Safen ven Sirolimus Hastalık ciddiyet indeksi Greft oklüzyonu, vasküler Yatış süresi Tedavi sonucu Paklitaksel İlaç salınımlı stentler Hastaneye yatırma Geriyedönük çalışma

Konular: Kalp ve Kalp Damar Sistemi

Safen ven greft lezyonlarının paklitaksel ve sirolimus salınımlı stentler ile tedavisi: Kısa ve uzun dönem klinik sonuçların karşılaştırılması

Öz:

Objective: The purpose of this study was to compare treatment of saphenous vein graft (SVG) lesions with paclitaxel-eluting (PES) and sirolimus-eluting stents (SES) in daily practice with regard to short- and long-term clinical outcomes. Methods: Between August 2002 and September 2006, a total of 71 patients with SVG lesions who were implanted PES or SES with percutaneous coronary intervention in our center were evaluated retrospectively. Forty-six patients with PES (PES group) were compared to twenty-five patients treated with SES (SES group) in terms of in-hospital, 30-day, six-months and 1-year clinical outcomes. Statistical analyses were performed using Chi-Square statistics or Fisher’s exact and independent sample t test. Survival analysis was done using Kaplan-Meier method and log-rank test. Results: Baseline clinical characteristics were similar in both groups except for a tendency toward a lower age in the SES group. No statistically significant difference was found between two groups by means of lesion and procedural characteristics. All clinical outcomes at 30-day, 6-month and 1-year after the interventions were similar in both groups. Early stent thrombosis was detected in one patient (2.2%) of PES group (p=0.65). Late stent thrombosis was not observed in both groups. The rate of major adverse cardiac events at 1-year was 8.7% in the PES group and 16% in the SES group (p=0.44). Conclusion: Short- and long-term clinical outcomes of PES and SES in the treatment of SVG lesions are similar. The results of our study showed that both drug-eluting stents are effective and safe in real-world patient with diseased SVGs.

Anahtar Kelime: Drug-Eluting Stents Hospitalization Retrospective Studies Angioplasty, Balloon, Coronary Kaplan-Meier Estimate Saphenous Vein Sirolimus Severity of Illness Index Graft Occlusion, Vascular Length of Stay Treatment Outcome Paclitaxel

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Görmez S, ERDİM R, ERDOĞMUŞ O, CİVAN M, ÇATAKOĞLU A, GÜLBARAN M, DEMİROĞLU C, AYTEKİN V (2008). Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. , 431 - 436.
Chicago	Görmez Selçuk,ERDİM Refik,ERDOĞMUŞ Onur,CİVAN Murat,ÇATAKOĞLU Alp Burak,GÜLBARAN Murat,DEMİROĞLU Cemşid,AYTEKİN Vedat Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. (2008): 431 - 436.
MLA	Görmez Selçuk,ERDİM Refik,ERDOĞMUŞ Onur,CİVAN Murat,ÇATAKOĞLU Alp Burak,GÜLBARAN Murat,DEMİROĞLU Cemşid,AYTEKİN Vedat Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. , 2008, ss.431 - 436.
AMA	Görmez S,ERDİM R,ERDOĞMUŞ O,CİVAN M,ÇATAKOĞLU A,GÜLBARAN M,DEMİROĞLU C,AYTEKİN V Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. . 2008; 431 - 436.
Vancouver	Görmez S,ERDİM R,ERDOĞMUŞ O,CİVAN M,ÇATAKOĞLU A,GÜLBARAN M,DEMİROĞLU C,AYTEKİN V Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. . 2008; 431 - 436.
IEEE	Görmez S,ERDİM R,ERDOĞMUŞ O,CİVAN M,ÇATAKOĞLU A,GÜLBARAN M,DEMİROĞLU C,AYTEKİN V "Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes." , ss.431 - 436, 2008.
ISNAD	Görmez, Selçuk vd. "Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes". (2008), 431-436.

APA	Görmez S, ERDİM R, ERDOĞMUŞ O, CİVAN M, ÇATAKOĞLU A, GÜLBARAN M, DEMİROĞLU C, AYTEKİN V (2008). Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. Anadolu Kardiyoloji Dergisi, 8(6), 431 - 436.
Chicago	Görmez Selçuk,ERDİM Refik,ERDOĞMUŞ Onur,CİVAN Murat,ÇATAKOĞLU Alp Burak,GÜLBARAN Murat,DEMİROĞLU Cemşid,AYTEKİN Vedat Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. Anadolu Kardiyoloji Dergisi 8, no.6 (2008): 431 - 436.
MLA	Görmez Selçuk,ERDİM Refik,ERDOĞMUŞ Onur,CİVAN Murat,ÇATAKOĞLU Alp Burak,GÜLBARAN Murat,DEMİROĞLU Cemşid,AYTEKİN Vedat Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. Anadolu Kardiyoloji Dergisi, vol.8, no.6, 2008, ss.431 - 436.
AMA	Görmez S,ERDİM R,ERDOĞMUŞ O,CİVAN M,ÇATAKOĞLU A,GÜLBARAN M,DEMİROĞLU C,AYTEKİN V Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. Anadolu Kardiyoloji Dergisi. 2008; 8(6): 431 - 436.
Vancouver	Görmez S,ERDİM R,ERDOĞMUŞ O,CİVAN M,ÇATAKOĞLU A,GÜLBARAN M,DEMİROĞLU C,AYTEKİN V Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes. Anadolu Kardiyoloji Dergisi. 2008; 8(6): 431 - 436.
IEEE	Görmez S,ERDİM R,ERDOĞMUŞ O,CİVAN M,ÇATAKOĞLU A,GÜLBARAN M,DEMİROĞLU C,AYTEKİN V "Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes." Anadolu Kardiyoloji Dergisi, 8, ss.431 - 436, 2008.
ISNAD	Görmez, Selçuk vd. "Treatment of saphenous vein graft lesions with paclitaxel- and sirolimus-eluting stents: comparison of short- and long-term clinical outcomes". Anadolu Kardiyoloji Dergisi 8/6 (2008), 431-436.