Yıl: 2008 Cilt: 15 Sayı: 3 Sayfa Aralığı: 43 - 53 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi

Öz:
Flor (F), yüksek elektronegatifliğe sahip, oldukça reaktif bir gazdır. Genellikle doğada serbest halde değil "flor bileşikleri (floridler)" şeklinde bulunur. Sularda, toprakta, kayalarda, atmosferde, yiyeceklerde, içeceklerde, bitki ve hayvanlarda rastlanan flor, en fazla çayda, tütünde ve balıkta mevcuttur. Flor, insan metabolizması için gerekli eser elementlerden biridir. Çocuk ve erişkinlerdeki çürük önleyici etkinlikleri kanıtlanan flor; doğal içme suyu flor konsantrasyonunun düşük olduğu (<0.5 ppm) coğrafi bölgelerde veya içme sularına ekonomik veya teknik yetersizlikler sebebiyle flor katılamayan ülkelerde, dişlerin çürükten korunması amacıyla bir halk sağlığı yöntemi olarak, sistemik ve topikal yollarla uygulanmakta ve bireylerdeki çürük prevalansı belirgin şekilde azaltılmaktadır. Günlük optimal flor dozu aşıldığında, vücutta çeşitli sistemik etkiler ortaya çıkar ve bunlardan ilki "Dental Florozis" tir. Doğal içme suyu ve kaynaklarında flor konsantrasyonunun yüksek olduğu coğrafi bölgelerde yaşayan kişilerde, .Endemik Florozis. tablosu yaygındır. Ayrıca son yıllarda endemik florozisin yanı sıra, diş hekimliğinde sistemik ve topikal flor uygulamaları ve kullanılan çeşitli restoratif materyallere ve ayrıca yiyecek, içecek ve vitaminlere flor katılması sebebiyle, çürük prevalansında belirgin bir azalmanın sağlandığı, ancak geçmişe oranla, dental florozisin görülme sıklığının arttığı bildirilmektedir. Dental florozis sıklığındaki bu artış, dişlerde hafiften şiddetliye değişen oranlarda estetik bozukluklara ve madde kayıplarına yol açabilmekte ve restoratif veya protetik tedavi gerekli olabilmektedir
Anahtar Kelime: Endemik hastalıklar Kronik hastalık Florozis, dental

Konular: Cerrahi

Evaluation of effects of fluor on human body and teeth in dentistry

Öz:
Fluor (F) is a highly electronegative and reactive gas. In nature, it was generally encountered as &#8220;fluor compounds (fluorides)&#8221;. Fluor is present in water, soil, rocks, atmosphere, foods, drinks, plants and animals and it&#8217;s mostly available in tea, tobacco and fish. Fluor is a trace element which is required for human metabolism. Caries preventive effects of fluor were proved. Fluor is applied with systemical and topical ways as a public health method for prevention of caries in geographical areas if their nature water concentration is decreased (<0.5 ppm) or if fluor could not been added in drinking water caused by economical or technical incapacities in some countries. If fluor is taken over &#8220;daily optimum fluor dose&#8221;, several systemical effetcs appear in the body. The first of these effects is &#8220;Dental Fluorosis&#8221;. Also, &#8220;Endemic Fluorosis&#8221; is common in persons living in geographical areas which have highly fluor concentrations in natural water and sources. Furthermore, in recent years, addition of fluor to dental products, foods, drinks and vitamins, and systemical and topical fluor applications in dentistry decreased the caries prevelance, however they increased the frequency of dental fluorosis. This increasing of dental esthetical disorders requires restorative or prosthetical treatmens of teeth.
Anahtar Kelime: Chronic Disease Fluorosis, Dental Endemic Diseases

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1- Venkateswarlu P. Evaluation of analytical methods for fluorine in biological and related materials. J Dent Res (Spec Iss) 1990; 69: 514-21.
  • 2- Nizel AE. Nutrition in Preventive Dentistry: Science and Practice. Chapter 13: Fluoride metabolism, safety and role in caries. Philadelphia, London, Toronto, W.B. Saunders Company 1972: 194-218
  • 3- Ekstrand J, Fejerskov O, Silverstone LM. Fluoride in Dentistry. 1st ed. Copenhagen, Munksgaard. 1988: 13-25, 96-192, 263-7.
  • 4- Horowitz HS. The water fluoridation and other systemic fluorides. J Dent Res 1990;69:760-4.
  • 5- Kunzel W. Systemic use of fluoride-other methods: Salt, sugar, milk, etc. Caries Res 1993; 27:16-22.
  • 6- Levy SM, Maurice TJ, Jakobsen JR. Feeding patterns, water sources and fluoride exposures of infants and 1-year . olds. JADA 1993;124:65-9.
  • 7- Mc Donald RE, Avery DR. Dentistry for the child and adolescent. 7th ed. Mosby Inc. 1999:362-72.
  • 8- Bryant BS, Retief DH, Bradley EL, Denys FR. The effect of topical fluoride treatment on enamel fluoride uptake and the tensile bond strength of an orthodontic bonding resin. Am J Orthod 1985;87(4):294-302.
  • 9- Hallgren A, Oliveby A, Twetman S. Salivary fluoride concentrations in children with glass ionomer cemented orthodontic appliances. Caries Res 1990;24:239-41.
  • 10-Whitford GM, Ekstrand J. Summary of Session I: Metabolism of fluoride. J Dent Res 1990; 69;2(3):513.
  • 11- Croll TP. Light-hardened glass-ionomer-resin cement restoration adjacent to a bonded orthodontic bracket: A case report. Quintessence Int 1994;25(1): 65-7.
  • 12- O.Mullane DM. The future of water fluoridation. J Dent Res 1990;69:756-9.
  • 13- Möller IJ. Fluorides and dental fluorosis. Int Dent J 1982; 32:135-47.
  • 14- Horowitz HS. Indexes for measuring dental fluorosis. J Public Health Dent 1986;46:179-83.
  • 15- Dean HT. Classification of mottled enamel diagnosis. 1934. In: Horowitz HS. Indexes for measuring dental fluorosis. J Public Health Dent 1986;46:179-83.
  • 16- Pendrys DG, Stamm JW. Relationship of total fluoride intake to beneficial effects and enamel fluorosis. J Dent Res 1990;69 (Spec Iss):529-38.
  • 17- Burt BA. The changing patterns of systemic fluoride intake. J Dent Res 1992;71:1228-37.
  • 18- Riordan PJ. Specialist clinicians perceptions of dental fluorosis. J Dent Child Spec Iss; 1993; July- October:315-20.
  • 19-Thylstrup A, Fejerskov O. Clinical appearance of dental fluorosis in permanent teeth in relation to histologic changes. Community Dent Oral Epidemiol 1978;6:315-28.
  • 20- Aras Ş, Küçükeşmen Ç, Küçükeşmen HC. Influences of dental fluorosis and deproteinisation treatment on shear bond strengths of composite restorations in permanent molar teeth. Abstract no. P38. Fluoride 2007; 40(4): 290-1.
  • 21- Mc Clure FJ. Water Fluoridation. The Search and the Victory. National Institute of Dental Research Bethesda, Maryland. Library of Congress Catalog Number: 75-604642. 1970; 75-82.
  • 22-Groeneveld A, Van Eck AAMJ, Backer Dirks O. Fluoride in caries prevention: Is the pre-or post- eruptive? J Dent Res 1990;69:751-55.
  • 23-Grobler SR, Von Wyk CW, Kotze D. Relationship between enamel fluoride levels, degree of fluorosis and caries experience in communities with a nearly optimal and a high fluoride level in the drinking water. Caries Res 1986;20:284-8.
  • 24-Whitford GM, Allmann DW, Shaned AR. Topical fluorides: effects on physiologic and biochemical process. J Dent Res; 1987;66(5):1072-8.
  • 25-Szpunar SM, Burt BA. Dental caries fluorosis and fluoride exposure among Michigan schoolchildren. J Dent Res 1988;67:802-6.
  • 26- Şaroğlu I, Aras Ş. Florozis. A.Ü. Diş Hek. Fak. Derg 2001;28(2):239-50.
  • 27- Küçükeşmen Ç, Sönmez H, Üşümez A, Küçükeşmen HC. Effects of dental fluorosis on microleakage from Class-V ormocer restorations in permanent molar teeth. Fluoride, 2007;40(2):134-9. Ê
  • 28-Kırzıoğlu Z, Küçükeşmen Ç, Altun AC, Erdoğan Y. Evaluation of caries incidence and severity of age- 6 teeth in children between 7 and 10 years-old with dental fluororsis and non-fluorosis. Abstract no: P37. Fluoride 2007; 40(4): 290.
  • 29- Dean HT. Chronic dental fluorosis. 1936. In: Grobler SR, Von Wyk CW, Kotze D. Relationship between enamel fluoride levels, degree of fluorosis and caries experience in communities with a nearly optimal and a high fluoride level in the drinking water. Caries Res 1986; 20:284-8.
  • 30- Heifetz SB, Horowitz HS. The amounts of fluoride in current fluoride therapies: Safety considerations for children. J Dent Child 1984;51:257-69.
  • 31- Heler KE, Eklund SA, Burt BA. Dental caries and dental fluorosis at varying water fluoride concentrations. J Public Health Dent 1997;57(3):136-43.
  • 32- Angelillo I, Torrel, Nobile CGA, Villari P. Caries and fluorosis prevalence in communities with different concentrations of fluoride in the water. Caries Res 1999;33:114-22.
  • 33- Dean HT. Fluorine in the control of dental caries. 1954. In: Pendrys DG, Stamm JW. Relationship of total fluoride intake to beneficial effects and enamel fluorosis. J Dent Res 1990;69 (Spec Iss): 529-38.
  • 34-Backer Dirks O, Kunzel W, Carlos JP. Caries preventive water fluoridation. Caries Res 1978;12 ( Suppl. 1):7-14.
  • 35-Mellberg JR, Ripa LW, Leske GS. Fluoride in Preventive Dentistry-theory and Clinical Applications. Chicago, Berlin, Rio de Janeiro and Tokyo. Quintessence Publishing Co. Inc.1983:123-45
  • 36- Larsen MJ, Richards A, Fejerskov O. Development of dental fluorosis according to age at start of fluoride administration. Caries Res 1985;19:519-27.
  • 37- Toumba KJ, Levy S, Curzon MEJ. The fluoride content of bottled drinking waters. Br Dent J 1994;176:266-8.
  • 38- Guha-Chowdhury N, Drummond BK, Smillie AC. Total fluoride intake in children aged 3 to 4 years-a longitudinal study. J Dent Res 1996;75(7):1451-7.
  • 39- Riordan PJ. Fluoride supplements in caries prevention. A literature review and proposal for a new dosage Schedule. J Public Health Dent. 1993;53(3):174-89.
  • 40- Mathewson RJ. Fundamentals of Dentistry for Children. Chapter:7. Clinical applications of Fluorides. 1982:147-171.
  • 41- Ölmez S, Altay N. Çocuklarda uygulanacak koruyucu diş hekimliği yöntemleri. TDBD 1998;44: 12-16.
  • 42- Ripa LW. Topical fluorides: A discussion of risks and benefits. J Dent Res 1987;66(5):1079-83.
  • 43- Carlos JP. Topical fluorides: Optimizing safety and efficacy-introduction. J Dent Res 1987;66(5):1055.
  • 44-Lecompte EJ. Clinical application of topical fluoride products-risks, benefits and recommendations. J Dent Res 1987;66(5):1066-71.
  • 45- Page DJ. A study of the effect of fluoride delivered from solution and dentifrices on enamel demineralization. Caries Res 1991;25:251-5.
  • 46- Peterson LG. Fluoride mouthrinses and fluoride varnishes. Caries Res 1992;27: 35-42.
  • 47- Strijp AJP, Buijs MJ, Ten Cate JM. In situ fluoride retention in enamel and dentine after the use of an amine fluoride dentifrice and amine fluoride/sodium fluoride mouthrinse. Caries Res 1999;33:61-5.
  • 48-Mellberg JR. Evaluation of topical fluoride preparations. J Dent Res 1990;69:771-9.
  • 49-Us Z, Ören C, Ulusu T, Orbey T. In vitro evaluation of fluoride uptake with application of APF to interproximal enamel of primary teeth using dental floss. J Dent Child 1995;8: 274-8.
  • 50-Stookey GK, De Paola PF, Featherstone JDB, Fejerskov O, Möller IJ, Rotberg S, Stephen KW, Wefel JS. A critical review of the relative anticaries efficacy of sodium fluoride and sodium monoflorophospate dentrifices. Caries Res 1993;27:337-60.
  • 51-Ekstrand J. Pharmacokinetic aspects of topical fluorides. J Dent Res 1987;66(5):1061-5.
  • 52-Menteş AR. Floridli diş macunlarının bugünkü durumunun değerlendirilmesi. Diş Hekimliğinde Klinik 1993;6(3):95-104.
  • 53-Osuji OO, Leake JL, Chipman ML, Nikiforuk G, Locker D, Levine N. Risk factors for dental fluorosis in a fluoridated community. J Dent Res 1988;67:1488-92.
  • 54- Bottenberg P, Declerck D, Ghidey W, Bogaerts K, Vanobbergen J, Martens L. Prevalence and determinants of enamel fluorosis in Flemish school children. Caries Res 2004;38(1):20-8.
  • 55- Bentley EM, Ellwood RP, Davies RM. Fluoride ingestion from toothpaste by young children. Br Dent J 1999;186(9): 460-2.
  • 56- Ripa LW. Need for prior tooth cleaning when performing a proffesional topical fluoride application: review and recommendations for change. JADA 1984;109:281-5.
  • 57- Warren JJ, Levy SM. A review of fluoride dentifrice related to dental fluorosis. Pediatr Dent 1999;21(4):265-71.
  • 58- Pendrys DG. Risk of enamel fluorosis in nonfluoridated and optimally fluoridated. Populations: considerations for the dental professional. JADA 2000;131:746-55.
  • 59- Mascarenhas AK. Risk factors for dental fluorosis: A review of the recent literature. Pediatr Dent 2000;22 (4): 269-77.
  • 60- Tabari ED, Ellwood R, Rugg-Gunn AJ, Evans DJ, Davies RM. Dental fluorosis in permanent incisor teeth in relation to water fluoridation, social deprivation and toothpaste use in infancy. Br Dent J 2000;189(4):216-20.
  • 61- Villena SR. An investigation of the transverse technique of dentifrice application to reduce the amount of fluoride dentifrice for young children. Pediatr Dent 2000;22 (4):312-7.
  • 62- Newbrun E. Topical fluoride therapy: Discussion of some aspects of toxicology, safety and efficacy. J Dent Res 1987;66(5):1084-6.
  • 63- Levy SM, Mc Grady JA, Bhuridej P, Warren JJ, Heilman JR, Wefel JS. Factors affecting dentifrice use and ingestion among a sample of US preschoolers. Pediatr Dent 2000;22(5):389-94.
  • 64- Ulusu F. Çocuk diş hekimliğinde flor. TDBD 1994;24:9-10.
  • 65- Tulga F. Fluorid uygulamaları. Türk Ortodonti Dergisi 1998;11(1):74-8.
  • 66- Küçükeşmen Ç, Sönmez H. Florozisli daimi insan dişlerinde, iki farklı bağlanma sisteminin, mineye bağlanma üzerine olan etkilerinin, in vitro olarak incelenmesi.ÊA:Ü Diş Hekimliği Fakültesi, Pedodonti ABD, Doktora Tezi 2007:7
  • 67- Dean HT, Jay P, Arnold FA, Elvove E. Domestic water and dental care II.1941. In: Grobler Sr, Von Wyk CW, Kotze D. Relationship between enamel fluoride levels, degree of fluorosis and caries experience in communities with a nearly optimal and a high fluoride level in the drinking water. Caries Res 1986;20:284-8.
  • 68- Dean HT, Arnold FA, Elvove E. Domestic water and dental caries. 1942. In: Grobler SR, Von Wyk CW, Kotze D. Relationship between enamel fluoride levels, degree of fluorosis and caries experience in communities with a nearly optimal and a high fluoride level in the drinking water. Caries Res 1986;20:284-8.
  • 69- Driscoll WS, Horowitz HS, Meyers RJ, Heifetz, Kingman A, Zimmerman ER. Prevalence of dental caries and dental fluorosis in areas with optimal and above- optimal water fluoride concentrations. JADA 1983;107:42-7.
  • 70- Irigojen ME, Molina N, Luengos. Prevalence and severity of dental fluorosis in a Mexican community with above-optimal fluoride concentration in drinking water. Community Dent Oral Epidemiol. 1995;23:243-5.
  • 71- Jackson RD, Kelly SA, Kotz BP, Hull JR, Stookey GK. Dental fluorosis and caries prevalence in children residing in communities with different levels of fluoride in the water. J Public Health Dent 1995;55(2):79-84.
  • 72- Ata P. Isparta.da endemik floroz ve diş çürüğü. 1955. In: Akyüz, S. Dünden bugüne fluor. Istanbul. 1997:69-75.
  • 73-Velicangil S, Demirhindi O. Isparta.da endemik fluorosis ve bu mevzu ile alakalı bazı problemler üzerinde araştırmalar.1957. In: Akyüz, S. Dünden bugüne fluor. Istanbul. 1997:69-75.
  • 74-Usmen E. Isparta il, ilçe ve köylerinde diş fluorosisi. 1976 In: Akyüz, S. Dünden bugüne fluor. Istanbul. 1997:69-75.
  • 75- Akyüz, S. Dünden bugüne fluor. Istanbul. 1997:69 75.
  • 76-Küçükeşmen Ç, Sönmez H. Microleakage of Class- V composite restorations with different bonding systems on fluorosed teeth. Eur J Dent 2008;2:48-58.
  • 77-Kırzıoğlu Z, Sağlam AMS, Şimşek S. Occlusal disharmonies of primary dentition in a high and a low fluoride area of Turkey. Fluoride 2005; 38(1): 57-64.
  • 78-Kırzıoğlu Z, Özay Ertürk MS, Karayılmaz H. Evaluation of dental caries and nursing caries prevalence in pre-school children living in a high fluoride area of Turkey. Fluoride 2004; 37(4): 290-2.
  • 79-Kırzıoğlu Z, Özay Ertürk MS, Karayılmaz H, Orhan H. Effects of dental fluorosis and salivary contamination on microleakage of four different restorative materials in primary molars. Fluoride 2006; 39: 220-7.
  • 80-Bozkurt FY, Gürsel M, Özdemir E, Fentoğlu Ö, Kıran M, Güngör I. Florozisin periodontal dokulara etkisinin klinik olarak incelenmesi. A.Ü Diş Hek Fak Derg 2000;27(2):215-25.
  • 81-Bozkurt FY, Kıran M. Yetiştirme yurdunda kalan 12- 16 yaş grubu bireylerde ağız sağlığı bulguları. C.Ü Diş Hek Fak Derg 2005; 8(1):31-7.
  • 82-Keçeci AD. Florozlu dişlerde tedavi alternatifleri: .Office-Bleaching + Home Bleaching. Göldent Isparta Burdur Diş hekimleri Odası Derg. 2000; 2: 11-5.
  • 83-Eser S. Kuzey Anadolu öğrencilerinde diş çürüğü prevalans ve etyolojisi. 1970. In: Akyüz, S. Dünden bugüne fluor. Istanbul. 1997:69-75.
  • 84-Baydaş S. Doğu Beyazıt köylerinde florosis. 1972. In: Akyüz, S. Dünden bugüne fluor. Istanbul. 1997:69-75.
  • 85-Gülhan A, Mermutlu B. Relations entre la fluorose endemique et la frequence de la carie. 1973. In: Akyüz, S. Dünden bugüne fluor. Istanbul. 1997:69-75.
  • 86- Mermutlu S, Mermutlu M. Endemic fluorosis in eastern Turkey. 1973. In: Akyüz, S. Dünden bugüne fluor. Istanbul. 1997:69-75.
  • 87- Mermutlu B. Endemik floroz bölgesinde diş taşlarının kimyasal analizi. 1977. In: Şaroğlu I, Aras Ş. Florozis. A. Ü. Diş Hek. Fak. Derg. 2001; 28(2): 239-50.
  • 88-Tanyeri K. (1975). Doğu Anadolu Bölgesi.nde endemik fluorosis. In: Akyüz, S. (1997). Dünden bugüne fluor. Istanbul; 69-75.
  • 89-Çolak S. (1990). Kırşehir ili-Çomalak Köyü.nde diş fluorosisi ve çürük sıklığı. In: Akyüz, S. Dünden bugüne fluor. Istanbul; 69-70.
  • 90- Saydam G, Oktay I, Moller I. (1990). Türkiye.de ağız diş sağlığı durum analizi. In: Akyüz, S. Dünden bugüne fluor. Istanbul; 69-75.
  • 91-Ulusu T, Ölmez S, Köse MR, Üstündağ M, Haznedaroğlu D, Aycan E. Türkiye.nin su fluor haritası. T.C Sağlık Bakanlığı, Ana Çocuk Sağlığı ve Aile Planlaması Genel Müdürlüğü, 2003, s. 3-442.
  • 92-WHO Technical Report Series. Fluorides and oral health. Geneva, 1994:1-35.
  • 93-Angmar-Mansson B, Whitford GM. Environmental and physiological factors affecting dental fluorosis. J Dent Res 1990;69:706-13.
  • 94-Robinson C, Kirkham J. The effect of fluoride on the developing mineralized tissues. J Dent Res 1990;69(Spec Iss):685-91.
  • 95-Warren JJ, Konnelis MJ, Levy SM. Fluorosis of the primary dentition; what does it mean for permanent teeth. JADA 1999;130:347-56.
  • 96-Jenkins GN. The physiology and biochemistry of the mouth. Philadelphia: W.B. Saunders Co.1978:489-497.
  • 97-Buischi Y, Burt BA, Ghandour I, Murray JJ, Mwaniki DL, O.Mullane D, Phantumvanit P, Wei SH. Fluorides and oral health. Report of a WHO expert committee on oral health status and fluoride use./Review. WHO, World Health Organisation, Geneva. WHO, Technical Report Series 1994:846.
  • 98-Fejerskov O, Larsen MJ, Richards A, Baelum V. Dental tissue effects of fluoride. Adv Dent Res 1994;8:15-31. 99-Whitford GM. The physiological and toxicological characteristics of fluoride. J Dent Res 1990;69:539-44.
  • 100-Whitford GM. Acute and chronic fluoride toxicity. J Dent Res 1992;71: 1249-54.
  • 101-Nişli N. Florür metabolizması ve florürün enzim sistemlerine etkisi. E.Ü. Diş Hek. Fak. Derg 1989;10(2):11-6.
  • 102- Angmar-Mansson B, Whitford GM. Plasma fluoride levels and enamel fluorosis in the rat. Caries Res 1982;16:334-9.
  • 103-Angmar-Mansson B, Whitford GM. Enamel fluorosis related to plasma F levels in the rat. Caries Res 1984;18:25-32.
  • 104- Angmar-Mansson B, Whitford GM. Single fluoride doses and enamel fluorosis in the rat. Caries Res 1985;19:145-52.
  • 105- Kühns C. Monatsschr. Zahnheilkd 1888. In: Horowitz HS. Indexes for measuring dental fluorosis. J Public Health Dent 1986;46:179-83.
  • 106- Den Besten PK, Thariani H. Biological mechanisms of fluorosis and level and timing of systemic exposure to fluoride with respect to fluorosis. J Dent Res 1992;71(5):1238-43.
  • 107- White DJ, Nancollas GH Physical and chemical considerations of the role of firmly and loosely bound fluoride in caries prevention. J Dent Res 1990;69:587-94.
  • 108- Gedalia I, Shapira L. Effect of prenatal and postnatal fluoride on the human decidiuous dentition. A literature review. Adv Dent Res 1989;3(2):168-76.
  • 109-Thylstrup A, Fejerskov O. Clinical appearance of dental fluorosis in permanent teeth in relation to histologic changes. Commun Dent Oral Epidemiol 1978;6:315-28.
  • 110- Dean HT. The investigation of physiological effects by the epidemiological method. 1942. In:Horowitz HS. Indexes for measuring dental fluorosis. J Public Health Dent 1986;46:179-83.
  • 111- Al-Sugair MH, Akpata ES. Effect of fluorosis on etching of human enamel. J Oral Rehabil 1999;26:521-8.
  • 112- Awliya WY, Akpata ES. Effect of fluorosis on shear bond strength of glass ionomer-based restorative materials to dentin. J Prosthet Dent 1999;8:290-4.
  • 113- Ateyah N, Akpata E. Factors affecting shear bond strength of composite resin to fluorosed human enamel. Oper Dent 2000;25:216-22.
  • 114- Ermis BR, Gokay N. Effect of fluorosis on dentine shear bond strength of a self-etching bonding system. J Oral Rehabil 2003;30:1090-4.
  • 115- Weerasinghe DS, Nikaido T, Wettasinghe KA, Abayakoon JB, Tagami J. Micro-shear bond strength and morphological analysis of a self-etching primer adhesive system to fluorosed enamel. J Dent 2005;33:419-26.
  • 116- Ermis RB, De Munck J, Cardoso MV, Coutinho E, Van Landuyt KL, Poitevin A, Lambrecths P, Van Meerbeek B. Bonding to ground versus enamel in fluorosed teeth. Dent Mater 2007; 8:Epub ahead of print. PMID:17215035.
  • 117- Fejerskov O, Manji F, Baelum V. The nature and mechanisms of dental fluorosis in man. J Dent Res 1990;69(Spec Iss):692-700.
  • 118- Leverett DH, Adoir SM, Vaughon BW, Proskin HM, Moss ME. Randomized clinical trial of the effect of prenatal fluorid supplements in preventing dental caries. Caries Res 1997;31: 174-9.
  • 119- Mann J, Mahmoud W, Ernest M, Sgan-Cohen H, Shoshen N, Gedalial I. Fluorosis and dental caries in 6-8 year-old children in a 5 ppm fluoride area. Community Dent Oral Epidemiol 1990;18(2):77-9.
  • 120- Mabelya L, Konig KG, Heldermen WH. Dental fluorosis, altitude and associated dietary factors. Caries Res 1992;26:65-7.
  • 121- Clark CD, Berkowitz J. The influence of various fluoride exposures on the prevalence of esthetic problems resulting from dental fluorosis. J Pub Health Dent 1997;57:144-9.
  • 122- Mc Knigth CB, Levy SM, Cooper SF, Jakobsen JR. A pilot study of esthetic perceptions of dental fluorosis vs selected other dental conditions. J Dent Child 1998; July-August 233-8.
  • 123- Riordan PJ. Perceptions of dental fluorosis. J Dent Res 1993;72(9):1268-74.
  • 124-Waggoner WF, Johnston WM, Schumann S, Schikowski E. Microabrasion of human enamel in vitro using hydrochloric acid and pumice. Pediatr Dent 1989;11(4):319-23.
  • 125-Çetiner S. Renkleşmiş dişlerin tedavisinde ağartma yöntemleri. TDBD 1992;20:20-3.
APA küçükeşmen ç, SÖNMEZ H (2008). Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. , 43 - 53.
Chicago küçükeşmen çiğdem,SÖNMEZ Hayriye Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. (2008): 43 - 53.
MLA küçükeşmen çiğdem,SÖNMEZ Hayriye Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. , 2008, ss.43 - 53.
AMA küçükeşmen ç,SÖNMEZ H Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. . 2008; 43 - 53.
Vancouver küçükeşmen ç,SÖNMEZ H Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. . 2008; 43 - 53.
IEEE küçükeşmen ç,SÖNMEZ H "Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi." , ss.43 - 53, 2008.
ISNAD küçükeşmen, çiğdem - SÖNMEZ, Hayriye. "Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi". (2008), 43-53.
APA küçükeşmen ç, SÖNMEZ H (2008). Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 15(3), 43 - 53.
Chicago küçükeşmen çiğdem,SÖNMEZ Hayriye Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 15, no.3 (2008): 43 - 53.
MLA küçükeşmen çiğdem,SÖNMEZ Hayriye Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, vol.15, no.3, 2008, ss.43 - 53.
AMA küçükeşmen ç,SÖNMEZ H Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi. 2008; 15(3): 43 - 53.
Vancouver küçükeşmen ç,SÖNMEZ H Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi. 2008; 15(3): 43 - 53.
IEEE küçükeşmen ç,SÖNMEZ H "Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi." Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 15, ss.43 - 53, 2008.
ISNAD küçükeşmen, çiğdem - SÖNMEZ, Hayriye. "Diş hekimliğinde florun, insan vücudu ve dişler üzerindeki etkilerinin değerlendirilmesi". Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 15/3 (2008), 43-53.