İntihar davranışının genetiği

ÖZALP, Elvan

İntihar davranışının genetiği

Elvan ÖZALP (Ankara Onkoloji Eğitim ve Araştırma Hastanesi, Psikiyatri Kliniği, Ankara, Türkiye)

Türk Psikiyatri Dergisi

91 15

Yıl: 2009 Cilt: 20 Sayı: 1 Sayfa Aralığı: 85 - 93 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

İntihar davranışının genetiği

Öz:

Günümüzde genetik etkenlerin intihar davranışının oluşumundaki rolü ile ilgili tutarlı kanıtlar vardır. Aile, ikiz, evlat edinme çalışmaları intiharın genetik bir boyutu olduğunu göstermiştir. İntihar ve duygudurum bozuklukları klinik olarak birbirleriyle örtüşen tablolar olmalarına ve hatta intihar riskini en çok psikiyatrik bozukluğun artırdığı bilinmesine rağmen, bazı hastaların intihar girişiminde bulunmamaları intihar davranışı için yapısal yatkınlık ya da genetik eğilimin varlığının önemine ve bunun da psikiyatrik hastalıktan bağımsız olduğuna işaret etmektedir. Son 30 yılı aşkın bir zamandır, araştırmalar intihar davranışı, agresyon ve dürtüsellik arasında bir ilişki olduğunu göstermiştir. Genetik etkenlerin dürtüsellik, agresyon gibi kişilik özelliklerinin oluşumunda rol oynayarak intihar davranışına sebep olabilecekleri düşünülmektedir. Pek çok moleküler genetik araştırma son zamanlarda keşfedilen aday genlerin intihar davranışıyla ilişkili olduğunu düşündürmektedir. Bu aday genlerden en önemlileri serotonin taşıyıcı reseptör (SERT), triptofan hidroksilaz (TPH), bazı serotonin reseptörleri (5HT1A, 5HT1B, 5HT2A), katekol-O-metiltransferaz (COMT), monoamin oksidaz A(MAOA), tirozin hidroksilaz (TH) genleridir. Bu gözden geçirme yazısı, geçmişten günümüze intihar davranışının genetik boyutunu incelemeyi amaçlamaktadır.

Anahtar Kelime:

Konular: Psikiyatri

The genetics of suicidal behavior

Öz:

There is consistent evidence suggesting that genetic factors play an important role in predisposition to suicidal behavior. Family, twin, and adoption studies have demonstrated that there is a genetic dimension to suicide. Although there is some overlap between suicide and mood disorders, even among psychiatric groups with the highest risk, some patients never attempt suicide, indicating the importance of a diathesis or genetic link to suicide that is independent of the underlying psychiatric disorder. Over the last 3 decades research has shown that there is a relationship between suicide, aggressiveness, and impulsivity. It is possible that genetic factors may be related to personality traits such as impulsiveness and aggressiveness, which in turn may lead to suicide attempts. An increasing number of molecular genetic studies have been carried out among cases involving suicidal behavior and candidate genes thought to be related to suicide. The most important candidate genes include the serotonin transporters (SERTs), tryptophan hydroxylase (TPH), some serotonin receptors (5HT1A, 5HT1B, and 5HT2A), catechol-O-methyltransferase (COMT), monoamine oxidase-A (MAO-A), and tyrosine hydroxylase (TH). The aim of this review was to assess the genetic dimension of suicide behavior, both current and historical.

Anahtar Kelime:

Konular: Psikiyatri

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	ÖZALP E (2009). İntihar davranışının genetiği. , 85 - 93.
Chicago	ÖZALP Elvan İntihar davranışının genetiği. (2009): 85 - 93.
MLA	ÖZALP Elvan İntihar davranışının genetiği. , 2009, ss.85 - 93.
AMA	ÖZALP E İntihar davranışının genetiği. . 2009; 85 - 93.
Vancouver	ÖZALP E İntihar davranışının genetiği. . 2009; 85 - 93.
IEEE	ÖZALP E "İntihar davranışının genetiği." , ss.85 - 93, 2009.
ISNAD	ÖZALP, Elvan. "İntihar davranışının genetiği". (2009), 85-93.

APA	ÖZALP E (2009). İntihar davranışının genetiği. Türk Psikiyatri Dergisi, 20(1), 85 - 93.
Chicago	ÖZALP Elvan İntihar davranışının genetiği. Türk Psikiyatri Dergisi 20, no.1 (2009): 85 - 93.
MLA	ÖZALP Elvan İntihar davranışının genetiği. Türk Psikiyatri Dergisi, vol.20, no.1, 2009, ss.85 - 93.
AMA	ÖZALP E İntihar davranışının genetiği. Türk Psikiyatri Dergisi. 2009; 20(1): 85 - 93.
Vancouver	ÖZALP E İntihar davranışının genetiği. Türk Psikiyatri Dergisi. 2009; 20(1): 85 - 93.
IEEE	ÖZALP E "İntihar davranışının genetiği." Türk Psikiyatri Dergisi, 20, ss.85 - 93, 2009.
ISNAD	ÖZALP, Elvan. "İntihar davranışının genetiği". Türk Psikiyatri Dergisi 20/1 (2009), 85-93.