Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease

EREL, Ozcan; SEZEN, Yusuf; Yıldız, Ali; Konukoglu, Oguz; Demirbag, Recep; Zeybek, Rahmi; RABUŞ, Murat; YAKUT, Cevat

Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease

Murat RABUŞ, (Sağlık Bakanlığı, Kartal Koşuyolu Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, İstanbul, Türkiye)

Recep DEMİRBAĞ, (Harran Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Şanlıurfa, Türkiye)

Yusuf SEZEN, (Harran Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Şanlıurfa, Türkiye)

Oğuz KONUKOĞLU, (Sağlık Bakanlığı, Kartal Koşuyolu Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, İstanbul, Türkiye)

Ali YILDIZ, (Harran Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Şanlıurfa, Türkiye)

Özcan EREL, (Harran Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Şanlıurfa, Türkiye)

Rahmi ZEYBEK, (Sağlık Bakanlığı, Kartal Koşuyolu Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, İstanbul, Türkiye)

Cevat YAKUT (Sağlık Bakanlığı, Kartal Koşuyolu Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, İstanbul, Türkiye)

Türk Kardiyoloji Derneği Arşivi

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Yıl: 2008 Cilt: 36 Sayı: 8 Sayfa Aralığı: 536 - 540 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease

Öz:

Amaç: Bu çalışmada, romatizmal ve dejeneratif kalp kapak hastalığında (KKH) plazma ve doku oksidatif stres indeksi (OSİ) açısından farklılık olup olmadığı araştırıldı. Ça lış ma pla nı: Çalışmaya kapak replasmanı yapılan 56 hasta alındı. Bunların 32’sinde (15 erkek; ort. yaş 47±10) romatizmal, 24’ünde (13 erkek; ort. yaş 55±12) dejeneratif KKH vardı. Plazma ve dokuda total oksidatif durum (TOD) ve total antioksidan kapasite (TAK) seviyeleri ölçüldü ve OSİ hesaplandı. Bul gu lar: Dejeneratif KKH grubunda yaş, interventriküler septum kalınlığı ve aort darlığının sıklığı anlamlı derecede fazlaydı; romatizmal KKH grubunda ise mitral darlığı sıklığı daha yüksek bulundu (p<0.05). Plazma oksidatif parametreleri iki KKH grubu arasında farklılık göstermedi (p>0.05). Doku örneklerinde ise, romatizmal KKH grubunda TAK anlamlı derecede daha düşük bulunurken (p=0.027), TOD ve OSİ değerleri iki grupta benzerdi (p>0.05). İkili korelasyon analizinde, incelenen hiçbir klinik, laboratuvar ve ekokardiyografik parametre OSİ ile anlamlı ilişki göstermedi (p>0.05). So nuç: Bulgularımız, plazma ve doku OSİ seviyelerinin romatizmal ve dejeneratif KKH’de benzer olduğunu göstermektedir.

Anahtar Kelime: Yaş faktörü Oksidatif stres Hastalık ciddiyet indeksi Risk faktörleri Antioksidanlar Romatizmal kalp hastalığı Ekokardiyografi Biyolojik belirteçler Yükseltgenme-indirgenme Kalp kapağı hastalıkları

Konular: Kalp ve Kalp Damar Sistemi

Romatizmal ve dejeneratif kalp kapak hastalarında doku ve plazma oksidatif stres indeksi

Öz:

Objectives: We investigated whether patients with rheumatic and degenerative heart valve disease (HVD) differed with regard to plasma and tissue oxidative stress index (OSI). Study design: The study included 56 patients who underwent valve replacement due to rheumatic (n=32; 15 males; mean age 47±10 years) and degenerative (n=24; 13 males; mean age 55±12 years) HVD. Plasma and tissue total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and OSI was calculated. Results: Patients with degenerative HVD had significantly higher age, increased interventricular septum thickness, and higher frequency of aortic stenosis, whereas the incidence of mitral stenosis was higher in patients with rheumatic HVD (p<0.05). Plasma oxidative characteristics did not differ between the two HVD groups (p>0.05). Tissue TAC was significantly lower in patients with rheumatic HVD (p=0.027), whereas tissue TOS and OSI were similar between the two HVD groups (p>0.05). In bivariate analysis, plasma OSI did not show any correlation with clinical, laboratory, and echocardiographic variables (p>0.05). Conclusion: Our data show that plasma and tissue OSI levels are similar in patients with rheumatic and degenerative HVD.

Anahtar Kelime: Rheumatic Heart Disease Echocardiography Biological Markers Oxidation-Reduction Heart Valve Diseases Age Factors Oxidative Stress Severity of Illness Index Risk Factors Antioxidants

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	RABUŞ M, Demirbag R, SEZEN Y, Konukoglu O, Yıldız A, EREL O, Zeybek R, YAKUT C (2008). Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. , 536 - 540.
Chicago	RABUŞ Murat,Demirbag Recep,SEZEN Yusuf,Konukoglu Oguz,Yıldız Ali,EREL Ozcan,Zeybek Rahmi,YAKUT Cevat Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. (2008): 536 - 540.
MLA	RABUŞ Murat,Demirbag Recep,SEZEN Yusuf,Konukoglu Oguz,Yıldız Ali,EREL Ozcan,Zeybek Rahmi,YAKUT Cevat Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. , 2008, ss.536 - 540.
AMA	RABUŞ M,Demirbag R,SEZEN Y,Konukoglu O,Yıldız A,EREL O,Zeybek R,YAKUT C Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. . 2008; 536 - 540.
Vancouver	RABUŞ M,Demirbag R,SEZEN Y,Konukoglu O,Yıldız A,EREL O,Zeybek R,YAKUT C Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. . 2008; 536 - 540.
IEEE	RABUŞ M,Demirbag R,SEZEN Y,Konukoglu O,Yıldız A,EREL O,Zeybek R,YAKUT C "Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease." , ss.536 - 540, 2008.
ISNAD	RABUŞ, Murat vd. "Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease". (2008), 536-540.

APA	RABUŞ M, Demirbag R, SEZEN Y, Konukoglu O, Yıldız A, EREL O, Zeybek R, YAKUT C (2008). Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Türk Kardiyoloji Derneği Arşivi, 36(8), 536 - 540.
Chicago	RABUŞ Murat,Demirbag Recep,SEZEN Yusuf,Konukoglu Oguz,Yıldız Ali,EREL Ozcan,Zeybek Rahmi,YAKUT Cevat Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Türk Kardiyoloji Derneği Arşivi 36, no.8 (2008): 536 - 540.
MLA	RABUŞ Murat,Demirbag Recep,SEZEN Yusuf,Konukoglu Oguz,Yıldız Ali,EREL Ozcan,Zeybek Rahmi,YAKUT Cevat Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Türk Kardiyoloji Derneği Arşivi, vol.36, no.8, 2008, ss.536 - 540.
AMA	RABUŞ M,Demirbag R,SEZEN Y,Konukoglu O,Yıldız A,EREL O,Zeybek R,YAKUT C Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Türk Kardiyoloji Derneği Arşivi. 2008; 36(8): 536 - 540.
Vancouver	RABUŞ M,Demirbag R,SEZEN Y,Konukoglu O,Yıldız A,EREL O,Zeybek R,YAKUT C Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Türk Kardiyoloji Derneği Arşivi. 2008; 36(8): 536 - 540.
IEEE	RABUŞ M,Demirbag R,SEZEN Y,Konukoglu O,Yıldız A,EREL O,Zeybek R,YAKUT C "Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease." Türk Kardiyoloji Derneği Arşivi, 36, ss.536 - 540, 2008.
ISNAD	RABUŞ, Murat vd. "Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease". Türk Kardiyoloji Derneği Arşivi 36/8 (2008), 536-540.