Factors related to non-alcoholic fatty liver disease in obese children

DALGIÇ, Buket; EMİNOĞLU, F.Tuba; OKTAR, Ö. Suna; ÇAMURDAN, Mahmut Orhun; BİDECİ, Aysun

Factors related to non-alcoholic fatty liver disease in obese children

F.Tuba EMİNOĞLU, (Gazi Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Ankara, Türkiye)

Ö. Suna OKTAR, (Gazi Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Ankara, Türkiye)

Aysun BİDECİ, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Ankara, Türkiye)

Buket DALGIÇ, (Gazi Üniversitesi, Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Ankara, Türkiye)

Mahmut Orhun ÇAMURDAN (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Gastroenterology

2 1

Yıl: 2008 Cilt: 19 Sayı: 2 Sayfa Aralığı: 85 - 91 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Factors related to non-alcoholic fatty liver disease in obese children

Öz:

Amaç: Alkole bağlı olmayan karaciğer yağlanmasının sıklığı çocukluk yaş grubunda obesiteye parallel olarak artmaktadır. Bu çalışma obez çocuklarda alkole bağlı olmayan karaciğer yağlanması ile ilişkili faktörleri belirlemek için planlandı. Yöntem: Çalışmaya 101 obez ve 68 obez olmayan çocuk katıldı. Karaciğ erde yağlanma varlığı ultrasonografi ile araştırıldı. Olgular 3 gruba ayrıldı; 53 yağlı karaciğeri olan obez hastalar (grup I), 48 karaciğerde yağlanma olmayan obez hastalar (grup II) ve 68 karaciğerde yağlanma olmayan kontrol olgu (grup III). Grup I’de kendi içinde 2 gruba ayrıldı; grade 1 yağlanması olan ( 44 hasta Grup Ia), yüksek grade yağlanması olan (9 hasta, Grup Ib). Vücut kitle indeksi, serum ALT, lipidler, leptin, insülin direnci indexi ile karaciğer yağlanması arasındaki ilişki incelendi. Bulgular: Obez çocukların %52,4’ünde karaciğer yağlanması, %13,8’inde yüksek ALT değerleri vardı. Aynı zamanda; ALT seviyesi yüksek olan hastaların tümünde karaciğer yağ- lanması mevcuttu. Leptin ve insülin direnci indexi düzeyleri Grup I ve II’de Grup III’e kıyasla yüksek olmasına rağmen vücut kitle indeksi ile düzeltme yapıldığında gruplar arasında fark kalmadı. Grup I'de serum ALT düzeyleri (31.5±30.2) Grup II (18.0±7.1) ve Grup III’e (14.5±5.2) kıyasla daha yüksek idi (p<0.05). Grup Ib’de ise ALT ve VLDL düzeylerinin Grup Ia’ya göre daha yüksek olduğu saptandı (p<0.05). Çoklu regresyon analizlerinde: Yağlanma üzerinde vücut kitle indeksi belirleyici, ALT düzeylerinde ise vücut kitle indeksi ve VLDL belirleyici olarak tanımlandı. Sonuç: Çalışmamız vücut kitle indeksi'nin karaciğer yağlanmasında belirleyici en önemli faktör olduğunu ve VLDL ile birlikte yüksek ALT düzeylerine katkıda bulunabileceğ ini düşündürdü. Ancak çalışmamızda leptinin bu sürece katkısı gösterilememiştir.

Anahtar Kelime: Leptin İnsülin Vücut kitle indeksi Hastalık ciddiyet indeksi Risk faktörleri Eş tanı Sebep sonuç ilişkisi Alanin transaminaz Olgu-kontrol çalışmaları Yağlı karaciğer Obezite Kan şekeri Lipoproteinler, VLDL

Konular: Cerrahi

Obez çocuklarda alkole bağlı olmayan yağlı karaciğer hastalığı ile ilişkili faktörler

Öz:

Background/aims: The incidence of non-alcoholic fatty liver disease has been increasing parallel to obesity in the pediatric age group. This study aimed to analyze the factors that are related to non-alcoholic fatty liver disease in obese children. Methods: 101 obese children and 68 non-obese controls were included in the study. Liver steatosis was investigated by ultrasonography. The subjects were divided into three groups: 53 obese patients with fatty liver (Group I), 48 obese patients without steatosis (Group II), and 68 controls without steatosis (Group III). Group I was further divided into those with Grade 1 steatosis (44 patients, Group Ia) and higher grades of steatosis (9 patients, Group Ib). The relationships of body mass index, serum ALT, lipids, leptin, and insulin resistance index with steatosis were analyzed. Results: 52.4% of obese children had fatty liver and 13.8% had high ALT levels. Additionally, all patients with elevated ALT levels were seen to have liver steatosis by ultrasonography. Leptin and insulin resistance index levels were higher in obese groups than controls; however, the difference disappeared when these levels were adjusted for body mass index. ALT levels were higher in Group I (31.5±30.2) than Group II (18.0±7.1) and Group III (14.5±5.2) (p<0.05). Group Ib showed higher VLDL and ALT levels than Group Ia (p<0.05). Multiple regression analysis revealed that body mass index was the most important determinant of liver steatosis, while body mass index and VLDL were the determinants of higher ALT levels. Conclusions: We suggest that body mass index and VLDL are the most important determinants of non-alcoholic fatty liver disease and elevated ALT levels in obese children. The contribution of leptin to this process could not be determined in our findings.

Anahtar Kelime: Comorbidity Causality Alanine Transaminase Case-Control Studies Fatty Liver Obesity Blood Glucose Lipoproteins, VLDL Leptin Insulin Body Mass Index Severity of Illness Index Risk Factors

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	EMİNOĞLU F, OKTAR Ö, BİDECİ A, DALGIÇ B, ÇAMURDAN M (2008). Factors related to non-alcoholic fatty liver disease in obese children. , 85 - 91.
Chicago	EMİNOĞLU F.Tuba,OKTAR Ö. Suna,BİDECİ Aysun,DALGIÇ Buket,ÇAMURDAN Mahmut Orhun Factors related to non-alcoholic fatty liver disease in obese children. (2008): 85 - 91.
MLA	EMİNOĞLU F.Tuba,OKTAR Ö. Suna,BİDECİ Aysun,DALGIÇ Buket,ÇAMURDAN Mahmut Orhun Factors related to non-alcoholic fatty liver disease in obese children. , 2008, ss.85 - 91.
AMA	EMİNOĞLU F,OKTAR Ö,BİDECİ A,DALGIÇ B,ÇAMURDAN M Factors related to non-alcoholic fatty liver disease in obese children. . 2008; 85 - 91.
Vancouver	EMİNOĞLU F,OKTAR Ö,BİDECİ A,DALGIÇ B,ÇAMURDAN M Factors related to non-alcoholic fatty liver disease in obese children. . 2008; 85 - 91.
IEEE	EMİNOĞLU F,OKTAR Ö,BİDECİ A,DALGIÇ B,ÇAMURDAN M "Factors related to non-alcoholic fatty liver disease in obese children." , ss.85 - 91, 2008.
ISNAD	EMİNOĞLU, F.Tuba vd. "Factors related to non-alcoholic fatty liver disease in obese children". (2008), 85-91.

APA	EMİNOĞLU F, OKTAR Ö, BİDECİ A, DALGIÇ B, ÇAMURDAN M (2008). Factors related to non-alcoholic fatty liver disease in obese children. Turkish Journal of Gastroenterology, 19(2), 85 - 91.
Chicago	EMİNOĞLU F.Tuba,OKTAR Ö. Suna,BİDECİ Aysun,DALGIÇ Buket,ÇAMURDAN Mahmut Orhun Factors related to non-alcoholic fatty liver disease in obese children. Turkish Journal of Gastroenterology 19, no.2 (2008): 85 - 91.
MLA	EMİNOĞLU F.Tuba,OKTAR Ö. Suna,BİDECİ Aysun,DALGIÇ Buket,ÇAMURDAN Mahmut Orhun Factors related to non-alcoholic fatty liver disease in obese children. Turkish Journal of Gastroenterology, vol.19, no.2, 2008, ss.85 - 91.
AMA	EMİNOĞLU F,OKTAR Ö,BİDECİ A,DALGIÇ B,ÇAMURDAN M Factors related to non-alcoholic fatty liver disease in obese children. Turkish Journal of Gastroenterology. 2008; 19(2): 85 - 91.
Vancouver	EMİNOĞLU F,OKTAR Ö,BİDECİ A,DALGIÇ B,ÇAMURDAN M Factors related to non-alcoholic fatty liver disease in obese children. Turkish Journal of Gastroenterology. 2008; 19(2): 85 - 91.
IEEE	EMİNOĞLU F,OKTAR Ö,BİDECİ A,DALGIÇ B,ÇAMURDAN M "Factors related to non-alcoholic fatty liver disease in obese children." Turkish Journal of Gastroenterology, 19, ss.85 - 91, 2008.
ISNAD	EMİNOĞLU, F.Tuba vd. "Factors related to non-alcoholic fatty liver disease in obese children". Turkish Journal of Gastroenterology 19/2 (2008), 85-91.