Yıl: 2009 Cilt: 26 Sayı: 1 Sayfa Aralığı: 9 - 11 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Factor V 1691 G-A mutation distribution in a healthy Turkish population

Öz:
Bu gözden geçirme makalesinde amaç, Faktör V 1691 G-A değişiminin sağlıklı Türk popülasyonunda yayınlanmış çalışmaların derlenmesi ve yayınlanmamış verilerin de yayınlanmasının sağlanmasıdır. Bu çalışmada 26 farklı bölgeden, FVL tayini yapılmış 4276 bireyden 345 bireyin taşıyıcı olduğu (% 7,9) belirlenmiştir. Yenidoğanlarda yapılmış iki çalışmada FVL taşıyıcı sıklığı % 10,9 olarak saptanmıştır.
Anahtar Kelime: Türk toplumu Faktör V leiden Türkiye Faktör V Nokta mutasyonu

Konular: Hematoloji

Sağlıklı Türk popülasyonunda faktör V (1691 G-A) mutasyon sıklığı

Öz:
The aim of this review was to compile published data on factor V 1691 G-A alteration in a healthy Turkish population and also to stimulate the reporting of unpublished data, in order to create a map for factor V Leiden (FVL) in Turkey. From a total of 4276 healthy individuals from 26 different centers of Turkey, 345 FVL carriers (7.9%) were determined. FVL was strikingly high among newborns from two different centers (10.9%).
Anahtar Kelime: Turkey Factor V Point Mutation Turkish population Factor V leiden

Konular: Hematoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995;346:1133-4.
  • 2. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-7.
  • 3. Pawar AR, Shetty S, Ghosh K, Mohanty D. How old is factor V Leiden mutation? Thromb Haemost 2001;86:1591-2.
  • 4. Dönmez Y, Kanadasi M, Tanriverdi K, Demir M, Demirtas M, Cayli M, Alhan C, Baslamisli F. Prothrombin 20210GA and factor V Leiden mutations in patients less than 55 years old with myocardial infarction. Jpn Heart J 2004;45:505-12.
  • 5. Akar N, Akar E, Dalgin G, Sözüöz A, Omürlü K, Cin S. Frequency of factor V (1691 G --> A) mutation in Turkish population. Thromb Haemost 1997;78:1527-8.
  • 6. Gürgey A, Mesci L. The prevalence of factor V Leiden (1691 G-->A) mutation in Turkey. Turk J Pediatr 1997;39:313-5.
  • 7. Aras S, Yilmaz G, Alpas I, Baltaci V, Tayanç E, Aydin P. Retinal vein occlusion and factor V Leiden and prothrombin 20210 G:A mutations. Eur J Ophthalmol 2001;11:351-5.
  • 8. Erkan O, Bozdayi AM, Disibeyaz S, Oguz D, Ozcan M, Bahar K, Karayalcin S, Ozden A, Bozkaya H, Yurdaydin C, Uzunalimoglu O. Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis. Eur J Gastroenterol Hepatol 2005;17:339-43.
  • 9. Toydemir PB, Elhan AH, Tükün A, Toydemir R, Gürler A, Tüzüner A, Bökesoy I. Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothrombin gene G20210A mutations on deep venous thrombogenesis in Behçet's disease. J Rheumatol 2000;27:2849-54.
  • 10. Yasa MH, Bolaman Z, Yukselen V, Kadikoylu G, Karaoglul AO, Batun S. Factor V Leiden G1691A, prothrombin G20210A, and MTHFR C677T mutations in Turkish inflammatory bowel disease patients. Hepatogastroenterology 2007;54:1438-42.
  • 11. Ağaoğlu N, Türkyilmaz S, Ovali E, Uçar F, Ağaoğlu C. Prevalence of prothrombotic abnormalities in patients with acute mesenteric ischemia. World J Surg 2005;29:1135-8.
  • 12. Kabukcu S, Keskin N, Keskin A, Atalay E. The frequency of factor V Leiden and concomitance of factor V Leiden with prothrombin G20210A mutation in healthy population of Denizli, Aegan region of Turkey. Clin Appl Thromb Hemost 2007;13:166-71.
  • 13. Irdem A, Devecioglu C, Batun S, Soker M, Sucakli IA. Prevalence of factor V Leiden and prothrombin G20210A gene mutation. Saudi Med J 2005;26:580 3.
  • 14. Yilmaz S, Bayan K, Tüzün Y, Batun S, Altıntaş A. A comprehensive analysis of 12 thromboembolic mutations and related parameters in patients with inflammatory bowel disease: data from Turkey. J Thromb Thrombolysis 2006;22:205-12.
  • 15. Kalkanlı S, Ayyıldız O, Tiftik N, Batun S, Isikdogan A, İnce H, Tekes S, Muftuoglu E. Factor V Leiden mutation in venous thrombosis in southeast Turkey. Angiology 2006;57:193-6.
  • 16. Gurlertop HY, Gundogdu F, Pirim I, Islamoglu Y, Egerci N, Sevimli S, Erdem F, Senocak H. Association between factor V Leiden mutation and coronary artery disease in the northeast region of Turkey. Blood Coagul Fibrinolysis 2007;18:719-22.
  • 17. Özbek U, Tangün Y. Frequency of factor V Leiden in Turkey. Br J Haemotol 1997;97:504-5.
  • 18. Gül A, Ozbek U, Oztürk C, Inanç M, Koniçe M, Ozçelik T. Coagulation factor V gene mutation increases the risk of venous thrombosis in Behçet's disease. Br J Rheumatol 1996;35:1178-80.
  • 19. Berber E, Kavaklı K, Akar N, Berber E, Çağlayan SH. R506Q (FV Leiden) and R485K mutations in the factor V gene: incidence in deep venous thrombosis and hemophilia A patients. Turk J Hematol 2003;20:221-5.
  • 20. Hobikoglu GF, Akyuz U, Akyuz F, Ozer O, Güney D, Narin A, Unaltuna N. Factor V Leiden is a risk factor for myocardial infarction in young Turkish men. Acta Cardiol 2004;59:594-7.
  • 21. Dölek B, Eraslan S, Eroğlu S, Kesim BE, Ulutin T, Yalçıner A, Laleli YR, Gözükırmızı N. Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A, methylenetetrahydrofolate reductase C677T and A1298C mutations related to Turkish thrombosis patients. Clin Appl Thromb Hemost 2007;13:435-8.
  • 22. Okumuş G, Kiyan E, Arseven O, Tabak L, Diz-Kucukkaya R, Unlucerci Y, Abaci N, Ünaltuna NE, Issever H. Hereditary thrombotic risk factors and venous thromboembolism in İstanbul, Turkey: the role in different clinical manifestations of venous thromboembolism. Clin Appl Thromb Hemost 2008; 14:168 73.
  • 23. Colak Y, Karasu Z, Oruc N, Can C, Balým Z, Akarca U, Gunsar F, Ersoz G, Tokat Y, Batur Y. Hyperhomocysteinaemia and factor V Leiden mutation are associated with Budd-Chiari syndrome. Eur J Gastroenterol Hepatol 2006;18:917 n20.
  • 24. Payzin B, Adakan FY, Yalçin HC, Cetinkaya GS, Berkmen S, Eraslan S, Unsal B. Natural coagulation inhibitory proteins and activated protein C resistance in Turkish patients with inflammatory bowel disease. Turk J Gastroenterol 2006;17:183-90.
  • 25. Görür K, Tuncer Ü, Eskandari G, Özcan C, Ünal M, Özsahinoglu C. The role of factor V Leiden and prothrombin G20210a mutations in sudden sensorineural hearing loss. Otol Neurotol 2005;26:599-601.
  • 26. Altintas A, Pasa S, Akdeniz N, Cil T, Yurt M, Ayyildiz O, Batun S, Isi H. Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey. Ann Hematol 2007;86:727-31.
  • 27. Kurt C, Tanrıverdi K, Koçak R. The frequency of factor V Leiden in southern Turkey. Ann Med Sci 1999;8:56.
  • 28. Celik S, Ovali E, Baykan M, Uçar F, Erdöl C, Durmuş I, Kaplan S. Factor V Leiden and its relation to left ventricular thrombus in acute myocardial infarction. Acta Cardiol 2001;56:1-6.
  • 29. Vurkun M, Vural Ö, Demir M. The prevalence of activated protein C resistance and F V Leiden in healthy population of Edirne, Turkey. Turk J Hematol 2002;19:287.
  • 30. Atasay B, Arsan S, Günlemez A, Kemahli S, Akar N. Factor V Leiden and prothrombin gene 20210A variant in neonatal thromboembolism and in healthy neonates and adults: a study in a single center. Pediatr Hematol Oncol 2003;20:627-34.
  • 31. Baytan B, Meral AG, İlçöl YÖ, Günay Ü. The prevalence of factor V Leiden (1691 G-A) and methylenetetrahydrofolate reductase C677T mutations in healthy newborns in Bursa, Turkey. Turk J Hematol 2007;24:90-2.
  • 32. Akar N. Frequency of hereditary thrombophilia in the Turkish population (effect of the age and genetic polymorphisms on the occurrence of thrombosis. Turk J Hematol 2000;17:3 (Suppl):230-3.
  • 33. Chaida C, Gialeraki A, Tsoukala C, Mandalaki T. Prevalence of the FVQ506 mutation in the Hellenic population. Thromb Haemost 1994;73:739-42.
  • 34. Cin Ş, Akar N, Arcasoy A, Dedeoğlu S, Çavdar AO. Prevalence of thalassemia and G6PD deficiency in North Cyprus. Acta Haematol 1984;71:69-70.
APA akar n (2009). Factor V 1691 G-A mutation distribution in a healthy Turkish population. , 9 - 11.
Chicago akar nejat Factor V 1691 G-A mutation distribution in a healthy Turkish population. (2009): 9 - 11.
MLA akar nejat Factor V 1691 G-A mutation distribution in a healthy Turkish population. , 2009, ss.9 - 11.
AMA akar n Factor V 1691 G-A mutation distribution in a healthy Turkish population. . 2009; 9 - 11.
Vancouver akar n Factor V 1691 G-A mutation distribution in a healthy Turkish population. . 2009; 9 - 11.
IEEE akar n "Factor V 1691 G-A mutation distribution in a healthy Turkish population." , ss.9 - 11, 2009.
ISNAD akar, nejat. "Factor V 1691 G-A mutation distribution in a healthy Turkish population". (2009), 9-11.
APA akar n (2009). Factor V 1691 G-A mutation distribution in a healthy Turkish population. Turkish Journal of Hematology, 26(1), 9 - 11.
Chicago akar nejat Factor V 1691 G-A mutation distribution in a healthy Turkish population. Turkish Journal of Hematology 26, no.1 (2009): 9 - 11.
MLA akar nejat Factor V 1691 G-A mutation distribution in a healthy Turkish population. Turkish Journal of Hematology, vol.26, no.1, 2009, ss.9 - 11.
AMA akar n Factor V 1691 G-A mutation distribution in a healthy Turkish population. Turkish Journal of Hematology. 2009; 26(1): 9 - 11.
Vancouver akar n Factor V 1691 G-A mutation distribution in a healthy Turkish population. Turkish Journal of Hematology. 2009; 26(1): 9 - 11.
IEEE akar n "Factor V 1691 G-A mutation distribution in a healthy Turkish population." Turkish Journal of Hematology, 26, ss.9 - 11, 2009.
ISNAD akar, nejat. "Factor V 1691 G-A mutation distribution in a healthy Turkish population". Turkish Journal of Hematology 26/1 (2009), 9-11.