A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows

ERDAG, DINÇER; KART, Asım; GIGREMIS, Yılmaz; BİLGİLİ, Ali; Hanedan, Başak

A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows

Ali BİLGİLİ, (Ankara Üniversitesi, Veteriner Fakültesi, Ankara, Türkiye)

Asım KART, (Kafkas Üniversitesi, Veteriner Fakültesi, Kars, Türkiye)

Yılmaz GIGREMIS, (Kafkas Üniversitesi, Kars, Türkiye)

BAŞAK HANEDAN, (Ankara Üniversitesi, Veteriner Fakültesi, Ankara, Türkiye)

DİNÇER ERDAĞ (Kafkas Üniversitesi, Kars, Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

14 1

Yıl: 2009 Cilt: 15 Sayı: 2 Sayfa Aralığı: 287 - 292 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows

Öz:

Avermektinlerden İvermektin ve Eprinomektin geniş spekturumlu endektositlerdir. Bu ilaçlar tedavi dozlarında ciddi yan etkileri olmayan ilaçlar olarak kabul edilir. Fakat avermektinler yüksek dozlarda hayvanlarda ve sağaltım dozunda insanlarda sinir sistemi ve genel semptomlarla karakterize bazı yan etkileri vardır. Bu çalışmada İvermektin ve Eprinomektin’in sağımdaki ineklerde plazma malondialdehid (MDA) ve glutatyon (GSH) seviyelerine etkisi araştUrUlmUştUr. 10 adet Holştayn ırkı süt veren inek 2 gruba ayrıldı. Grup 1 ve grup 2 ye sırasıyla tek doz olarak dökme tarzında İvermektin (0.5 mg/kg vücut ağırlığı) ve Eprinomektin (0.5 mg/kg vücut ağUrlUğU) uygulandU. İlaç uygulamasından önce kan örnekleri 0. saatte kontrol uygulamasU olarak vena jugularis’ten alındı. Kan örnekleri ilaç uygulamasını takiben belirli zaman aralıklarında (1, 4, 8, 24 ve 36. saatlerde ve 2, 3, 4, 5, 6, 8, 10, 12, 15, 20, ve 25. günlerde) yine jugular ven’den toplandı. Eprinomektin ve İvermektin GSH seviyesinde geçici bir düşmeye ve takiben yine geçici bir artışa sebep oldu (P<0.05). Fakat MDA seviyelerinde herhangi bir değişikliğe rastlanmadı (P>0.05). Sonuç olarak, Eprinomektin ve İvermektinin plazma GSH seviyesinde geçici bir düşmeye sebeb olarak antioksidan kapasitede bir düşüşe neden olabileceği fakat bu düşüşün lipid peroksidasyonuna yol açmayacak derecede olduğu sonucuna varıldı.

Anahtar Kelime: yan etkiler malondialdehit glutatyon inek ivermektin antihelmintikler kan plazması lipit peroksidasyonu eprinomektin antioksidanlar

Konular: Veterinerlik

İneklerde eprinomektin ve ivermektin'in plazma antioksidan ve lipid peroksidasyonu üzerine etkisinin karşılaştırmalı araştırılması

Öz:

Avermectins including Ivermectin and Eprinomectin are broad spectrum endectocides. These drugs are considered to have no serious adverse effects at therapeutic range. However, use of avermectins in overdose in some animal species and at the therapeutic range in humans could result in some adverse effects including mainly nervous system effects and some general symptoms. This study was aimed to investigate effects of Eprinomectin and Ivermectin on plasma malondialdehyde (MDA) and glutathione (GSH) levels in lactating cow. Ten Holstein breed lactating dairy cows were divided into 2 groups. Before the application of drugs, blood samples were collected from the jugular vein in each group at 0 hour as control, and then Group 1 and 2 received a single pour-on application of Ivermectin (0.5 mg/kg body weight) and Eprinomectin (0.5 mg/kg body weight), respectively. Blood samples were then collected again from the jugular vein at timed-intervals (at 1, 4, 8, 24 and 36 hours and on 2, 3, 4, 5, 6, 8, 10, 12, 15, 20 and 25th days) to measure plasma MDA and GSH concentrations. Eprinomectin and Ivermectin treatment caused a transient decrease in GSH levels which is followed by transient increase (P<0.05). However, no difference was observed in MDA levels at all sampling points following the Eprinomectin and Ivermectin treatment compared to control samples (P>0.05). It was concluded that Eprinomectin and Ivermectin cause decreased GSH concentrations without alterations in MDA level leading to a decrease in the defense mechanism against oxidative stress although the decrease is not enough to cause lipid peroxidation.

Anahtar Kelime: ivermectin anthelmintics blood plasma lipid peroxidation eprinomectin antioxidants adverse effects malondialdehyde glutathione cows

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BİLGİLİ A, KART A, GIGREMIS Y, Hanedan B, ERDAG D (2009). A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. , 287 - 292.
Chicago	BİLGİLİ Ali,KART Asım,GIGREMIS Yılmaz,Hanedan Başak,ERDAG DINÇER A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. (2009): 287 - 292.
MLA	BİLGİLİ Ali,KART Asım,GIGREMIS Yılmaz,Hanedan Başak,ERDAG DINÇER A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. , 2009, ss.287 - 292.
AMA	BİLGİLİ A,KART A,GIGREMIS Y,Hanedan B,ERDAG D A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. . 2009; 287 - 292.
Vancouver	BİLGİLİ A,KART A,GIGREMIS Y,Hanedan B,ERDAG D A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. . 2009; 287 - 292.
IEEE	BİLGİLİ A,KART A,GIGREMIS Y,Hanedan B,ERDAG D "A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows." , ss.287 - 292, 2009.
ISNAD	BİLGİLİ, Ali vd. "A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows". (2009), 287-292.

APA	BİLGİLİ A, KART A, GIGREMIS Y, Hanedan B, ERDAG D (2009). A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 15(2), 287 - 292.
Chicago	BİLGİLİ Ali,KART Asım,GIGREMIS Yılmaz,Hanedan Başak,ERDAG DINÇER A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 15, no.2 (2009): 287 - 292.
MLA	BİLGİLİ Ali,KART Asım,GIGREMIS Yılmaz,Hanedan Başak,ERDAG DINÇER A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.15, no.2, 2009, ss.287 - 292.
AMA	BİLGİLİ A,KART A,GIGREMIS Y,Hanedan B,ERDAG D A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2009; 15(2): 287 - 292.
Vancouver	BİLGİLİ A,KART A,GIGREMIS Y,Hanedan B,ERDAG D A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2009; 15(2): 287 - 292.
IEEE	BİLGİLİ A,KART A,GIGREMIS Y,Hanedan B,ERDAG D "A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 15, ss.287 - 292, 2009.
ISNAD	BİLGİLİ, Ali vd. "A comparative study on the effects of eprinomectin and ıvermectin on plasma antioxidant level and lipid peroxidation in cows". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 15/2 (2009), 287-292.