Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives

ÜNVER, YASEMİN; DÜĞDÜ, Esra; ER, MUSTAFA; SANCAK, KEMAL; Alpay Karaoğlu, Şengül

Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives

Yasemin ÜNVER, (Karadeniz Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Trabzon, Türkiye)

Esra DÜĞDÜ, (Karadeniz Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Trabzon, Türkiye)

Kemal SANCAK, (Karadeniz Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Trabzon, Türkiye)

Mustafa ER, (Karadeniz Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Trabzon, Türkiye)

ŞENGÜL ALPAY KARAOĞLU (Rize Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Rize, Türkiye)

Turkish Journal of Chemistry

1 0

Yıl: 2009 Cilt: 33 Sayı: 1 Sayfa Aralığı: 135 - 147 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives

Öz:

4-[Arylidene-amino]-3-thiophen-2-ylmethyl-4,5-dihydro[1,2,4]triazole-5-one compounds (3a-g) with Schiff base character were obtained from the reaction of 4-amino-3-thiophen-2-ylmethyl-4,5-dihydro-1H-[1,2,4]triazole- 5-one (2) with various aldehydes. 1-(2-Oxo-2-phenyl-ethyl)-4-[arylidene-amino]-3-thiophen-2-ylmethyl-4,5- dihydro-1H-[1,2,4]triazole-5-ones (4a-g) were synthesized from the reaction of corresponding compounds 3ag with bromoacetophenone. 1-(2-Hydroxy-2-phenyl-ethyl)-3-thiophen-2-ylmethyl-4-[aryl-amino]4,5-dihydro- 1H-[1,2,4]triazole-5-ones (5a-g) and 1-(2-hydroxy-2-phenyl-ethyl)-3-thiophen-2-ylmethyl-4-[arylidene-amino]4,5- dihydro-1H-[1,2,4]triazole-5-ones (6b,d,e) were obtained from the selective reduction of 1-(2-oxo-2-phenylethyl)- 4-[arylidene-amino]-3-thiophen-2ylmethyl-4,5-dihydro-1H-[1,2,4] triazole-5-ones (4) with NaBH4. They were characterized by IR, $^1 H-NMR$, $^{13}C-NMR$, and elemental analyses. Compounds 2, 3a, 3c, 3g, 4f, 5b, and 5g showed good antifungal activity against yeast-like fungi. Compounds selected by the National Cancer Institute (NCI, USA) were investigated for antitumor activity.

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÜNVER Y, DÜĞDÜ E, SANCAK K, ER M, Alpay Karaoğlu Ş (2009). Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. , 135 - 147.
Chicago	ÜNVER YASEMİN,DÜĞDÜ Esra,SANCAK KEMAL,ER MUSTAFA,Alpay Karaoğlu Şengül Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. (2009): 135 - 147.
MLA	ÜNVER YASEMİN,DÜĞDÜ Esra,SANCAK KEMAL,ER MUSTAFA,Alpay Karaoğlu Şengül Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. , 2009, ss.135 - 147.
AMA	ÜNVER Y,DÜĞDÜ E,SANCAK K,ER M,Alpay Karaoğlu Ş Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. . 2009; 135 - 147.
Vancouver	ÜNVER Y,DÜĞDÜ E,SANCAK K,ER M,Alpay Karaoğlu Ş Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. . 2009; 135 - 147.
IEEE	ÜNVER Y,DÜĞDÜ E,SANCAK K,ER M,Alpay Karaoğlu Ş "Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives." , ss.135 - 147, 2009.
ISNAD	ÜNVER, YASEMİN vd. "Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives". (2009), 135-147.

APA	ÜNVER Y, DÜĞDÜ E, SANCAK K, ER M, Alpay Karaoğlu Ş (2009). Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. Turkish Journal of Chemistry, 33(1), 135 - 147.
Chicago	ÜNVER YASEMİN,DÜĞDÜ Esra,SANCAK KEMAL,ER MUSTAFA,Alpay Karaoğlu Şengül Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. Turkish Journal of Chemistry 33, no.1 (2009): 135 - 147.
MLA	ÜNVER YASEMİN,DÜĞDÜ Esra,SANCAK KEMAL,ER MUSTAFA,Alpay Karaoğlu Şengül Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. Turkish Journal of Chemistry, vol.33, no.1, 2009, ss.135 - 147.
AMA	ÜNVER Y,DÜĞDÜ E,SANCAK K,ER M,Alpay Karaoğlu Ş Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. Turkish Journal of Chemistry. 2009; 33(1): 135 - 147.
Vancouver	ÜNVER Y,DÜĞDÜ E,SANCAK K,ER M,Alpay Karaoğlu Ş Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives. Turkish Journal of Chemistry. 2009; 33(1): 135 - 147.
IEEE	ÜNVER Y,DÜĞDÜ E,SANCAK K,ER M,Alpay Karaoğlu Ş "Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives." Turkish Journal of Chemistry, 33, ss.135 - 147, 2009.
ISNAD	ÜNVER, YASEMİN vd. "Synthesis and antimicrobial and antitumor activitiy of some new (1,2,4) triazole-5-one derivatives". Turkish Journal of Chemistry 33/1 (2009), 135-147.