The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes

GAYATHRI, Mahallingam; KANNABİRAN, Krishnan

The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes

Mahallingam GAYATHRI, (School of Biotechnology Chemical and Biomedical Engineering VIT Univercity Vellore 632 014 Tamil Nadu., India)

Krishnan KANNABİRAN (School of Biotechnology Chemical and Biomedical Engineering VIT Univercity Vellore 632 014 Tamil Nadu., India)

Turkish Journal of Biology

1 0

Yıl: 2009 Cilt: 33 Sayı: 1 Sayfa Aralığı: 9 - 13 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes

Öz:

Bu çalışmada Ficus bengalensis gövde kabuğu sıvı ekstresinin sub kronik uygulamasının streptozotosin (STZ) ile indüklenmiş diyabetik ratların hematolojik ve biyokimyasal parametrelerine etkisi değerlendirilmiştir. STZ ile indüklenmişdeki değişimlere F. bengalensis (500 mg/kg vücut ağırlığı/gün) ekstraktının olası koruyucu etkisi 12 hafta için test edilmiştir. Diyabetik ratlarda parametre olarak total protein, albumin, globulini kapsayan plazma proteinleri, üre, ürik asit, kreatinini kapsayan protein olmayan azotlu bileşikleri ve toplam hemoglobin miktarı, eritrosit, lökosit, trombosit miktarını kapsayan hematolojik veriler değerlendirilmiştir. Protein metabolizması ve hematolojik veriler ışığında STZ ile indüklenmiş değişimlere karşı sıvı ekstrakt önemli (P < 0,05) koruyucu etki göstermiştir. Ayrıca protein olmayan azotlu maddelerin artan düzeyleri ekstrakt uygulaması ile normal düzeylere indirilmiştir. Bu nedenle F. bengalensis’in sıvı ektresi, ratlarda STZ ile indüklenmiş değişimlerde biyokimyasal ve hematolojik parametreler üzerine üstün koruyucu etkiye sahiptir.

Anahtar Kelime: hematoloji deneysel diabetikler tıbbi bitkiler bitki özütü streptezotosin sıçan biyokimyasal parametreler Ficus benghalensis diyabet

Konular: Biyoloji

Oral yolla uygulanan Ficus bengalensis gövde Kabuğu sıvı ekstresinin streptozotosin ile indüklenmiş diyabetik ratların bazı hematolojik ve biyokimyasal parametreleri üzerine etkisi

Öz:

The effects of sub-chronic administration of an aqueous extract of Ficus bengalensis stem bark on hematological and biochemical parameters in rats with streptozotocin (STZ)-induced diabetes were evaluated. The possible protective effect of the F. bengalensis (500 mg/kg of body weight per day) extract on STZ-induced changes was evaluated over 12 weeks. The parameters evaluated were plasma proteins, including total protein albumin and globulin, non-protein nitrogenous substances, including urea, uric acid, and creatinine, and hematological indices, including total hemoglobin content, erythrocytes, leucocytes, and platelets counts. The aqueous extract had a significant (P < 0.05) protective effect against STZ-induced changes in terms of the markers of protein metabolism and hematological indices. Furthermore, increases in levels of non-protein nitrogenous substances were normalized in response to the administration of the extract. Thus, the aqueous extract of F. bengalensis had a significant protective effect on STZinduced changes to biochemical and hematological parameters in the diabetic rats.

Anahtar Kelime: streptozotocin rats biochemical parameters Ficus benghalensis diabetes haematology experimental diabetes medicinal plants plant extracts

Konular: Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GAYATHRI M, KANNABİRAN K (2009). The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. , 9 - 13.
Chicago	GAYATHRI Mahallingam,KANNABİRAN Krishnan The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. (2009): 9 - 13.
MLA	GAYATHRI Mahallingam,KANNABİRAN Krishnan The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. , 2009, ss.9 - 13.
AMA	GAYATHRI M,KANNABİRAN K The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. . 2009; 9 - 13.
Vancouver	GAYATHRI M,KANNABİRAN K The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. . 2009; 9 - 13.
IEEE	GAYATHRI M,KANNABİRAN K "The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes." , ss.9 - 13, 2009.
ISNAD	GAYATHRI, Mahallingam - KANNABİRAN, Krishnan. "The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes". (2009), 9-13.

APA	GAYATHRI M, KANNABİRAN K (2009). The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. Turkish Journal of Biology, 33(1), 9 - 13.
Chicago	GAYATHRI Mahallingam,KANNABİRAN Krishnan The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. Turkish Journal of Biology 33, no.1 (2009): 9 - 13.
MLA	GAYATHRI Mahallingam,KANNABİRAN Krishnan The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. Turkish Journal of Biology, vol.33, no.1, 2009, ss.9 - 13.
AMA	GAYATHRI M,KANNABİRAN K The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. Turkish Journal of Biology. 2009; 33(1): 9 - 13.
Vancouver	GAYATHRI M,KANNABİRAN K The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes. Turkish Journal of Biology. 2009; 33(1): 9 - 13.
IEEE	GAYATHRI M,KANNABİRAN K "The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes." Turkish Journal of Biology, 33, ss.9 - 13, 2009.
ISNAD	GAYATHRI, Mahallingam - KANNABİRAN, Krishnan. "The effects of oral administration of an aqueous extract of Ficus bengalensis stem bark on some hematological and biochemical parameters in rats with streptozotocin-induced diabetes". Turkish Journal of Biology 33/1 (2009), 9-13.