Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz

ÖZDEMİR, Özlem; VATANSEVER, Sevgül; CANITEZ, Yakup; TURAN, HAKAN; Sarıcaoğlu, Hayriye

Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz

Hakan TURAN, (Uludağ Üniversitesi, Tıp Fakültesi, Bursa, Türkiye)

Sevgül VATANSEVER, (Uludağ Üniversitesi, Tıp Fakültesi, Bursa, Türkiye)

Özlem ÖZDEMİR, (Uludağ Üniversitesi, Tıp Fakültesi, Bursa, Türkiye)

Yakup CANITEZ, (Uludağ Üniversitesi, Tıp Fakültesi, Bursa, Türkiye)

Hayriye SARICAOĞLU (Uludağ Üniversitesi, Tıp Fakültesi, Bursa, Türkiye)

Güncel Pediatri

6 0

Yıl: 2008 Cilt: 6 Sayı: 3 Sayfa Aralığı: 104 - 110 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz

Öz:

Amaç: Steven’s Johnson Sendromu (SJS) ve Toksik Epidermal Nekroliz (TEN) tanısı almış çocuk hastalarda klinik bulgular, sorumlu etkenler, laboratuvar sonuçları, komplikasyonlar ve tedavi seçeneklerinin gözden geçirilmesi amaçlandı. Gereç ve Yöntem: Uludağ Üniversitesi Tıp Fakültesi Dermatoloji Anabilim Dalı, Çocuk Nöroloji Bilim Dalı ve Çocuk Alerji Bilim Dalı’na 2000-2008 yılları arasında başvuran SJS ve TEN tanısı almış olan hastalar retrospektif olarak incelenmiştir. Bulgular: Toplam 14 hastanın (7’si kız ve 7’si erkek) kayıtları incelendi. Hastaların 9’u SJS, 2’si SJS-TEN overlap sendrom, 3’ü TEN idi. Dokuz hastanın epilepsi tanısı ile, diğer hastaların anksiyete, diş apsesi, kriptik tonsillit, otitis media ve bronşit tanıları ile ilaç kullanım öyküleri mevcuttu. Hastaların 11’inde (%78,5) çoklu ilaç kullanımı bulunmaktaydı. SJS/TEN etyolojisinde 7 hastada (%50) Lamotrijin (7 hastanın 4'ünde ek olarak Valproik asit kullanımı vardı) diğer hastalarda Okskarbamazepin, Azitromisin, Fenitoin, İmipramin, Sefuroksim aksetil, Siprofloksasin, Seftriakson kullanımının sorumlu olduğu düşünüldü. Oniki hastaya sistemik kortikosteroid, 2 hastaya intravenöz immünglobulin tedavisi uygulanmıştı ve hastaların tümünde tam iyileşme görüldüğü saptandı. Sonuç: İlaç reaksiyonları çocuklarda erişkinlere oranla daha az görülmekle birlikte uzun süreli ve çoklu ilaç kullanımı olan çocuk hastalarda, SJS ve TEN gibi şiddetli ilaç reaksiyonlarının gelişme riski göz önünde bulundurulmalıdır.

Anahtar Kelime: Epidermal nekroliz, toksik Stevens-Johnson sendromu Çocuk İlaç toksisitesi Geriyedönük çalışma

Konular: Alerji Pediatri

Steven’s Johnson syndrome and toxic epidermal necrolysis in children

Öz:

Aim: The aim of this study was to consider clinical features, laboratory findings, treatment alternatives, complications and responsible agents of Steven’s Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in childhood.Materials and Method: The patients who were diagnosed with Steven’s Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) and followed by Department of Dermatology, Division of Pediatric Neurology and Division of Pediatric Allergy of Uludag University Faculty of Medicine, between 2000-2008 were evaluated retrospectively. Results: Records of 14 patients (7 females/7 males) were examined. Nine of the patients had SJS, 2 had SJS-TEN overlap syndrome and the rest 3 had TEN. Nine patients had history of using drugs for epilepsy and the others for anxiety, tooth abscess, cryptic tonsillitis, otitis media and bronchiolitis. Eleven of the patients (78.5%) had multiple drug intake. In 7 patients (50%) Lamotrigine (4 of 7 patients was also taken Valproic acid) and in other patients oxcarbamazepine, azytromicine, phenytoin, imipramine, cefuroxime axetil, ciprofloxacin, ceftriaxone were responsible for SJS and TEN. Twelve patients were treated with systemic corticosteroids and 2 with intravenous immunoglobulin. All of the patients were cured. Conclusion: Although drug reactions were seen less frequently in children compared to adults, it must be taken into consideration that there is the risk of developing severe drug reactions like SJS and TEN in children who have been using such drugs for a long time or using multipl drugs for extended period

Anahtar Kelime: Stevens-Johnson Syndrome Child Drug Toxicity Retrospective Studies Epidermal Necrolysis, Toxic

Konular: Alerji Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TURAN H, VATANSEVER S, ÖZDEMİR Ö, CANITEZ Y, Sarıcaoğlu H (2008). Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. , 104 - 110.
Chicago	TURAN HAKAN,VATANSEVER Sevgül,ÖZDEMİR Özlem,CANITEZ Yakup,Sarıcaoğlu Hayriye Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. (2008): 104 - 110.
MLA	TURAN HAKAN,VATANSEVER Sevgül,ÖZDEMİR Özlem,CANITEZ Yakup,Sarıcaoğlu Hayriye Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. , 2008, ss.104 - 110.
AMA	TURAN H,VATANSEVER S,ÖZDEMİR Ö,CANITEZ Y,Sarıcaoğlu H Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. . 2008; 104 - 110.
Vancouver	TURAN H,VATANSEVER S,ÖZDEMİR Ö,CANITEZ Y,Sarıcaoğlu H Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. . 2008; 104 - 110.
IEEE	TURAN H,VATANSEVER S,ÖZDEMİR Ö,CANITEZ Y,Sarıcaoğlu H "Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz." , ss.104 - 110, 2008.
ISNAD	TURAN, HAKAN vd. "Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz". (2008), 104-110.

APA	TURAN H, VATANSEVER S, ÖZDEMİR Ö, CANITEZ Y, Sarıcaoğlu H (2008). Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. Güncel Pediatri, 6(3), 104 - 110.
Chicago	TURAN HAKAN,VATANSEVER Sevgül,ÖZDEMİR Özlem,CANITEZ Yakup,Sarıcaoğlu Hayriye Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. Güncel Pediatri 6, no.3 (2008): 104 - 110.
MLA	TURAN HAKAN,VATANSEVER Sevgül,ÖZDEMİR Özlem,CANITEZ Yakup,Sarıcaoğlu Hayriye Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. Güncel Pediatri, vol.6, no.3, 2008, ss.104 - 110.
AMA	TURAN H,VATANSEVER S,ÖZDEMİR Ö,CANITEZ Y,Sarıcaoğlu H Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. Güncel Pediatri. 2008; 6(3): 104 - 110.
Vancouver	TURAN H,VATANSEVER S,ÖZDEMİR Ö,CANITEZ Y,Sarıcaoğlu H Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz. Güncel Pediatri. 2008; 6(3): 104 - 110.
IEEE	TURAN H,VATANSEVER S,ÖZDEMİR Ö,CANITEZ Y,Sarıcaoğlu H "Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz." Güncel Pediatri, 6, ss.104 - 110, 2008.
ISNAD	TURAN, HAKAN vd. "Çocuklarda Steven’s Johnson sendromu ve toksik epidermal nekroliz". Güncel Pediatri 6/3 (2008), 104-110.