The purpose this study was to investigate the effect of reading material prepared with PowerPoint software on the reading comprehension skills of students with mild mental retardation. In the study, the improvement processes of the mild mentally retarded students’ reading comprehension levels were examined by using the reading materal prepared in PowerPoint software. The AB design model, a single-subject design model, was used in the study. The subjects in the research were three mild mentally retarded children attending the integration class in a state primary school. The research was carried out in two phases, data collection at the start-level and application process. In order to collect data in the start-level and application process, material for determining the level of understanding a vocabulary item that they read, vocabulary cards, a data recording form for understanding the vocabulary, sentence reading cards, a data recording form for understanding the sentence, texts that were read independently, a data recording form for understanding the texts were prepared and used. The research was categorized under four sub-categories: reading comprehension skill, vocabulary understanding, sentence understanding, and text understanding. The material was applied and the collected data were interpreted in the light of graphical analysis. According to the findings, the material, that is prepared in PowerPoint program in which visuality stands in the forefront, helps the students make concrete and give meaning to the word, sentence and the text. As a result, the use of the reading material prepared in PowerPoint is useful in improving the reading comprehension skills of mild mentally retarded students.