Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species

SAVAŞAN, Serap; Diker, Kadir Serdar; ÇİFTÇİ, Alper; İÇA, Tuba

Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species

Tuba İÇA, (Erciyes Üniversitesi, Veteriner Fakültesi, Kayseri, Türkiye)

Alper ÇİFTÇİ, (Ondokuz Mayıs Üniversitesi, Veteriner Fakültesi, Samsun, Türkiye)

Serap SAVAŞAN, (Adnan Menderes Üniversitesi, Veteriner Fakültesi, Mikrobiyoloji Anabilim Dalı, Aydın, Türkiye)

Kadir Serdar DİKER (Ankara Üniversitesi, Veteriner Fakültesi, Ankara, Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2009 Cilt: 15 Sayı: 4 Sayfa Aralığı: 629 - 632 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species

Öz:

Bu çalışmada çeşitli hayvanlardan izole edilen Campylobacter jejuni ve Campylobacter coli suşlarında metronidazol direnç sıklığının belirlenmesi ve karşılaştırılması amaçlandı. Çalışmada tavuk, sığır, koyun ve köpek kökenli 240 C. jejuni/C.coli izolatının metronidazol Minimum İnhibisyon Konsantrasyon (MIC) değerleri agar dilusyon tekniği ile incelendi. Direnç sıklığı 133 tavuk, 32 sığır, 48 koyun ve 27 köpek orijinli izolatlar için sırasıyla %91.7, %18.75, %16.7, ve %18.5 oranlarında bulundu. Yüz yetmiş C. jejuni izolatının %52.9’unda ve 70 C. coli suşunun %72.85’inde metronidazol dirençliliği saptandı. Farklı hayvan izolatları için metronidazol MIC (mcg/ml) aralıkları şu şekilde bulundu; tavuk, 2->64; sığır, 0.25-32, koyun, 0.12-16 ve köpek, 0.25-32. Farklı hayvan izolatları için metronidazol MIC50/MIC90 değerleri; tavuk 16/64 (mcg/ml), sığır 2/8 (mcg/ml), koyun 1/8 (mcg/ml) ve köpek 2/8 (mcg/ml) olarak tespit edildi. Çalışma sonucunda kampilobakterlerde metronidazol duyarlılığı bakımından çeşitlilik olduğu ve direnç sıklığının suşun kökenine göre değiştiği anlaşıldı. Dirençli suşların tavuklarda neden daha sık görüldüğü açıklanamamakla birlikte metronidazol dirençliliği bakımından bir konak fenotip varlığının olduğu ortaya konuldu.

Anahtar Kelime: sığır antibiyotiklere duyarlılık metronidazol direnç hayvan hastalıkları Campylobacter jejuni antibiyotikler köpek koyun Campylobacter coli tavuk

Konular: Veterinerlik

Farklı hayvan türlerinden izole edilen Campylobacter jejuni ve Campylobacter coli türlerinin metronidazol duyarlılıkları

Öz:

In this study, we aimed to screen animal isolates of Campylobacter jejuni/Campylobacter coli for resistance to metronidazole and compared the resistance of selected groups of isolates. A total of 240 C. jejuni/C. coli isolates isolated from chickens, cattle, sheep and dogs were tested by an agar dilution technique to determine the Minimum Inhibitory Concentration (MIC) of metronidazole. The frequency of resistance in 133 avian, 32 bovine, 48 ovine and 27 canine isolates were 91.7%, 18.75%, 16.7% and 18.5%, respectively. Of 170 C. jejuni and 70 C. coli isolates tested, 52.9% and 72.85% were resistant to metronidazole, respectively. MIC (mcg/ml) ranges of metronidazole for animal isolates were as follows: chicken, 2->64; cattle, 0.25-32; sheep, 0.12-16 and dog, 0.25-32. MIC50/MIC90 values of metronidazole for animal isolates were as follows: chicken 16/64 (mcg/ml), cattle 2/8 (mcg/ml), sheep 1/8 (mcg/ml) and dog 2/8 (mcg/ml). We observed a wide range of sensitivity to metronidazole among campylobacters and frequency of resistance differed in relation to the origin of the isolate. Although it was not clear why the resistant isolates were common in chickens, a host-phenotype relationship for metronidazole resistance was demonstrated..

Anahtar Kelime: antibiotics dogs sheep Campylobacter coli fowls cattle antibiotic sensivity metronidazole resistance animal diseases Campylobacter jejuni

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	İÇA T, ÇİFTÇİ A, SAVAŞAN S, Diker K (2009). Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. , 629 - 632.
Chicago	İÇA Tuba,ÇİFTÇİ Alper,SAVAŞAN Serap,Diker Kadir Serdar Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. (2009): 629 - 632.
MLA	İÇA Tuba,ÇİFTÇİ Alper,SAVAŞAN Serap,Diker Kadir Serdar Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. , 2009, ss.629 - 632.
AMA	İÇA T,ÇİFTÇİ A,SAVAŞAN S,Diker K Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. . 2009; 629 - 632.
Vancouver	İÇA T,ÇİFTÇİ A,SAVAŞAN S,Diker K Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. . 2009; 629 - 632.
IEEE	İÇA T,ÇİFTÇİ A,SAVAŞAN S,Diker K "Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species." , ss.629 - 632, 2009.
ISNAD	İÇA, Tuba vd. "Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species". (2009), 629-632.

APA	İÇA T, ÇİFTÇİ A, SAVAŞAN S, Diker K (2009). Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 15(4), 629 - 632.
Chicago	İÇA Tuba,ÇİFTÇİ Alper,SAVAŞAN Serap,Diker Kadir Serdar Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 15, no.4 (2009): 629 - 632.
MLA	İÇA Tuba,ÇİFTÇİ Alper,SAVAŞAN Serap,Diker Kadir Serdar Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.15, no.4, 2009, ss.629 - 632.
AMA	İÇA T,ÇİFTÇİ A,SAVAŞAN S,Diker K Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2009; 15(4): 629 - 632.
Vancouver	İÇA T,ÇİFTÇİ A,SAVAŞAN S,Diker K Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2009; 15(4): 629 - 632.
IEEE	İÇA T,ÇİFTÇİ A,SAVAŞAN S,Diker K "Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 15, ss.629 - 632, 2009.
ISNAD	İÇA, Tuba vd. "Metronidazole resistance of Campylobacter jejuni and Campylobacter coli from different animal species". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 15/4 (2009), 629-632.