TY  - JOUR
TI  - Decreasing selenium levels and glutathione peroxidase activity in patients with cutaneous leishmaniasis
AB  - For most infectious diseases, increased formation of reactive oxygen species is secondary to the primary disease process. Some microorganisms are highly susceptible to exogenous reactive oxygen species such as hydrogen peroxide. Glutathione peroxidase (GSH-Px) remove H 2 O 2 , and selenium is requird for the activity of GSH-Px. Therefore, to assess the status of GSH-Px and selenium in cutaneous leishmaniasis (CL), we determined serum selenium concentration and blood GSH-Px activity in 52 patients with CL and in 38 healthy controls. Selenium concentrations and GSH-Px activities were found to be lower in the patient group than in the controls (p<0.0001). Serum albumin and hematocrit % (Htc%) levels were not different in patients than in controls. There were positive relationships between selenium concentrations and GSH-Px activities (r=0.703, p<0.0001), selenium and albumin ( r= 0.344, p<0.05), GSH-Px and Htc%(r=0.48, p<0.01) in CL patients. We suggest that selenium has an important role in the pathophysiologic processes of CL, and that the decreasing levels of selenium may be a host defense strategy of the organism against CL infection.
AU  - EREL, Ozcan
AU  - GÜR, Selahattin
AU  - AKTEPE, Necmeddin
AU  - GUREL, Mehmet Salih
AU  - Kocyigit, Abdurrahim
AU  - AVCI, Şenel
AU  - SEYREK, Adnan
PY  - 1999
JO  - Turkish Journal of Medical Sciences
VL  - 29
IS  - 3
SN  - 1300-0144
SP  - 291
EP  - 295
DB  - TRDizin
UR  - http://search/yayin/detay/9221
ER  -