Yıl: 2009 Cilt: 37 Sayı: 3 Sayfa Aralığı: 168 - 173 Metin Dili: Türkçe

Relationship between elevated serum gamma-glutamyltransferase activity and slow coronary flow

Öz:
Amaç: Çalışmamızda yavaş koroner kan akımı (YKA) olan hastalarda serum gama-glutamiltransferaz (GGT) aktivitesi ile koroner kan akımı arasındaki ilişki araştırıldı. Ça­lış­ma pla­nı: Çalışmaya YKA saptanan 90 hasta (47 erkek, 43 kadın; ort. yaş 50.8±9.4) ve koroner arter hastalığı (KAH) olan 88 hasta (45 erkek, 43 kadın; ort. yaş 50.8±9.4) alındı. Yavaş koroner kan akımı ve KAH tanıları koroner anjiyografi ile kondu. Koroner arter hastalığı olan grupta normal koroner akım vardı. Tüm hastalarda koroner akım düzeltilmiş TIMI kare sayısı ile değerlendirildi ve serum GGT düzeyleri ölçüldü. Sonuçlar, yaş ve cinsiyet uyumlu ve koroner arterleri ve koroner akımı normal bulunan 86 hastadan oluşan kontrol grubuyla karşılaştırıldı. Bul­gu­lar: Gruplar arasında beden kütle indeksi, hipertansiyon ve diyabet varlığı, lipit profili ve açlık kan şekeri açısından fark yoktu. Koroner arter hastalığı olan grupta ilaç kullanımı anlamlı derecede fazlaydı (p<0.01). Kontrol grubuyla karşılaştırıldığında, serum GGT aktivitesi YKA’lı ve KAH’li gruplarda anlamlı derecede yüksek bulundu (p<0.01); ancak, iki grup arasında bu açıdan fark yoktu (p=0.71). Epikardiyal koroner arterlerde ölçülen TIMI kare sayıları ve ortalama TIMI kare sayısı YKA grubunda anlamlı derecede yüksek bulundu (p<0.01). TIMI kare sayıları açısından KAH grubu ile kontrol grubu arasında fark yoktu. Ortalama TIMI kare sayısı serum GGT düzeyi ile orta düzeyde pozitif ilişki gösterdi (r=0.326; p<0.001). Regresyon analizinde, serum GGT aktivitesi ortalama TIMI kare sayısını öngörmede tek bağımsız değişken idi (β=0.309; p<0.001). So­nuç: Çalışmamızda artmış serum GGT aktivitesi ile YKA arasındaki ilişki ilk kez gösterilmiş olmaktadır. Serum GGT aktivitesinin YKA’da tam patofizyolojik rolünü ortaya koymak için ileri çalışmalara ihtiyaç vardır.
Anahtar Kelime:

Yüksek serum gama-glutamiltransferaz aktivitesi ile yavaş koroner akım arasındaki ilişki

Öz:
Objectives: We evaluated the relationship between coronary blood flow and serum gamma-glutamyltransferase(GGT) activity in patients with slow coronary flow (SCF).Study design: The study included 90 patients (47 men,43 women; mean age 50.8±9.4 years) with SCF and 88patients (45 men, 43 women; mean age 51.4±8.8 years)with coronary artery disease (CAD), whose diagnoses weremade by coronary angiography. Patients with CAD had nor- mal coronary flow. Coronary flow was quantified using thecorrected TIMI frame count (TFC) method and serum levelsof gamma-glutamyltransferase were measured. The resultswere compared with those of a control group consisting of86 age- and sex-matched patients who had normal coronaryarteries and normal coronary flow. Results: The three groups were similar with respect tobody mass index, presence of hypertension and diabetesmellitus, lipid profiles, and fasting glucose. The use of medi- cations was significantly more common in the CAD group(p<0.01). Compared to the control group, serum GGT activ- ity was significantly increased in both SCF and CAD groups(p<0.01), but these two groups did not differ significantly inthis respect (p=0.71). The TFCs for all the epicardial coro- nary arteries and the mean TFC were significantly higher inthe SCF group (p<0.01). Patients with CAD and the controlshad similar TFC parameters. The mean TFC showed apositive and moderate correlation with serum GGT activ- ity (r=0.326; p<0.001). In regression analysis, serum GGTactivity was found as the only independent predictor of themean TFC (&#946;=0.309; p<0.001). Conclusion: We have shown for the first time an asso- ciation between increased serum GGT activity and SCF.Further clinical studies are needed to clarify the physio- pathologic role of serum GGT activity in SCF.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ŞEN N, ÖZLÜ M, BAŞAR N, ÖZCAN F, GÜNGÖR Ö, TURAK O, MALÇOK Ö, ÇAĞLI K, MADEN O, ERBAY A, DEMİR A (2009). Relationship between elevated serum gamma-glutamyltransferase activity and slow coronary flow. Türk Kardiyoloji Derneği Arşivi, 37(3), 168 - 173.
Chicago ŞEN Nihat,ÖZLÜ Mehmet F.,BAŞAR Nurcan,ÖZCAN Fırat,GÜNGÖR Ömer,TURAK Osman,MALÇOK Özgül,ÇAĞLI Kumral,MADEN ORHAN,ERBAY Ali R.,DEMİR Ahmet D. Relationship between elevated serum gamma-glutamyltransferase activity and slow coronary flow. Türk Kardiyoloji Derneği Arşivi 37, no.3 (2009): 168 - 173.
MLA ŞEN Nihat,ÖZLÜ Mehmet F.,BAŞAR Nurcan,ÖZCAN Fırat,GÜNGÖR Ömer,TURAK Osman,MALÇOK Özgül,ÇAĞLI Kumral,MADEN ORHAN,ERBAY Ali R.,DEMİR Ahmet D. Relationship between elevated serum gamma-glutamyltransferase activity and slow coronary flow. Türk Kardiyoloji Derneği Arşivi, vol.37, no.3, 2009, ss.168 - 173.
AMA ŞEN N,ÖZLÜ M,BAŞAR N,ÖZCAN F,GÜNGÖR Ö,TURAK O,MALÇOK Ö,ÇAĞLI K,MADEN O,ERBAY A,DEMİR A Relationship between elevated serum gamma-glutamyltransferase activity and slow coronary flow. Türk Kardiyoloji Derneği Arşivi. 2009; 37(3): 168 - 173.
Vancouver ŞEN N,ÖZLÜ M,BAŞAR N,ÖZCAN F,GÜNGÖR Ö,TURAK O,MALÇOK Ö,ÇAĞLI K,MADEN O,ERBAY A,DEMİR A Relationship between elevated serum gamma-glutamyltransferase activity and slow coronary flow. Türk Kardiyoloji Derneği Arşivi. 2009; 37(3): 168 - 173.
IEEE ŞEN N,ÖZLÜ M,BAŞAR N,ÖZCAN F,GÜNGÖR Ö,TURAK O,MALÇOK Ö,ÇAĞLI K,MADEN O,ERBAY A,DEMİR A "Relationship between elevated serum gamma-glutamyltransferase activity and slow coronary flow." Türk Kardiyoloji Derneği Arşivi, 37, ss.168 - 173, 2009.