The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women

TABAK, Yalçın; Altay, Murat; ÖZKURT, Bülent; ÇAĞLAYAN, Osman; AKTEKİN, Cem Nuri; ÖZKURT, Zübeyde Nur

The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women

Bülent ÖZKURT, (Ankara Numune Eğitim ve Araştırma Hastanesi, 5. Ortopedi ve Travmatoloji Kliniği, Ankara, Türkiye)

Zübeyde Nur ÖZKURT, (Gazi Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Ankara, Türkiye)

Murat ALTAY, (Ankara Numune Eğitim ve Araştırma Hastanesi, 5. Ortopedi ve Travmatoloji Kliniği, Ankara, Türkiye)

Cem Nuri AKTEKİN, (Ankara Numune Eğitim ve Araştırma Hastanesi, 5. Ortopedi ve Travmatoloji Kliniği, Ankara, Türkiye)

Osman ÇAĞLAYAN, (Kırıkkale Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Kırıkkale, Türkiye)

Yalçın TABAK (Ankara Numune Eğitim ve Araştırma Hastanesi, 5. Ortopedi ve Travmatoloji Kliniği, Ankara, Türkiye)

Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.)

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Yıl: 2009 Cilt: 20 Sayı: 2 Sayfa Aralığı: 78 - 84 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women

Öz:

Amaç: Bu çalışmada serum adiponektin düzeyi ile kemik kütlesi ve serum adiponektin düzeyi ile osteoporotik kırıklar arasındaki olası ilişki prospektif olarak araştırıldı. Hastalar ve yöntemler: Kalça kırığı olan menopoz sonrası diyabetik olmayan 105 kadın hasta (ort. yaş 63.4±8.1; dağılım 52-64 yıl) prospektif olarak değerlendirildi. Hastaların 46’sı trokanterik, 24’ü subtrokanterik ve 35’i femoral boyun kırıklı idi. Antropometrik ölçümler yapıldı. Serum adiponektin düzeyi ELISA ile değerlendirildi. Lomber ve femoral kemik mineral yoğunluğu ve kemik mineral içeriği çift enerjili X-ışını soğurma cihazı (DEXA) ile ölçüldü. Bulgular: Lomber ve femoral kemik mineral yoğunluğu serum adiponektin düzeyi ile ilişkili bulunmadı. Serum adiponektin düzeyinin kemik kütlesi üzerinde anlamlı bir etkisi saptanmadı. Osteoporotik kırıklı hastalarda ve osteoporozla ilişkisiz kırıklı hastalar arasında serum adiponektin düzeyleri yönünden anlamlı bir fark saptanmadı. Sonuç: Bizim çalışmamızda serum adiponektin düzeyi ile kemik kütlesi ve osteoporotik kırık riski arasında klinik düzeyde bir ilişki bulunamamış olsa da kemik dokudaki lokal adiponektin düzeyinin incelendiği çalışmalar yapılarak bu olası ilişki daha net ortaya çıkarılabilir.

Anahtar Kelime: Kemik yoğunluğu Postmenopoz Antropometri Adiponektin Absorptiyometri, foton Osteoporoz

Konular: Ortopedi

Menopoz sonrası kadınlarda serum adiponektin ve antropometrinin kemik kütlesi ve osteoporotik kırık riski ile ilişkisi kemik kütlesi ve osteoporotik kırık riski ile ilişkisi

Öz:

Objectives: The aim of the present study was to evaluate the possible correlation between bone mass and serum adiponectin levels, and the correlation between adiponectin levels and osteoporotic fracture risk in a prospective clinical trial. Patients and methods: Postmenopausal non-diabetic 105 women (mean age 63.4±8.1; range 52 to 64 years) with hip fracture were evaluated. Of these 105 patients, 46 had trochanteric fractures, 24 had subtrochanteric fractures and 35 had femoral neck fractures. Anthropometric measurements were performed. Serum adiponectin level was measured by means of ELISA. Total bone mineral density and bone mineral content of lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry (DEXA). Results: Lumbar bone mineral density and proximal femoral bone mineral density were not correlated with serum adiponectin levels. Serum adiponectin level was not found to have any significant effect on bone mass. Serum adiponectin levels were not significantly different between the patients with osteoporotic fractures and those with non-osteoporotic fractures. Conclusion: Our study showed that serum adiponectin level is not associated with bone mass and osteoporotic fracture risk. Investigation of local adiponectin levels in bony tissue is needed to clarify the possible relation between adiponectin and bone mass, and risk of fractures associated with osteoporosis.

Anahtar Kelime: Adiponectin Absorptiometry, Photon Osteoporosis Bone Density Postmenopause Anthropometry

Konular: Ortopedi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. American Association of Clinical Endocrinologists Osteoporosis Task Force. American Association of clinical endocrinologists 2001 medical guidelines for clinical practice for the prevention and management of postmenopausal osteoporosis. Endocr Pract 2001;7:293-312.
2. Solomon DH, Morris C, Cheng H, Cabral D, Katz JN, Finkelstein JS, et al. Medication use patterns for osteoporosis: an assessment of guidelines, treatment rates, and quality improvement interventions. Mayo Clin Proc 2005;80:194-202.
3. Başaran A, Sarıbay GF, Akın S, Korkusuz F. Bone mineral density is not affected by salt consumption in diet. [Article in Turkish] Eklem Hastalık Cerrahisi 2006;17:15-20.
4. Atik OS. Osteoporotic fracture risk assestment. [Article in Turkish] Eklem Hastalık Cerrahisi 2008;19:1.
5. Kozacı DL, Şavk ŞÖ, Özkan İ, Çullu E, Alparslan B, Yürekli Y, et al. Evaluation of osteoporozis in early and late postmenopausal women: correlations between bone mineral density and bone turn over markers. [Article in Turkish] Eklem Hastalık Cerrahisi 2006;17:28-32.
6. Hla MM, Davis JW, Ross PD, Wasnich RD, Yates AJ, Ravn P, et al. A multicenter study of the influence of fat and lean mass on bone mineral content: evidence for differences in their relative influence at major fracture sites. Early Postmenopausal Intervention Cohort (EPIC) Study Group. Am J Clin Nutr 1996;64:354-60.
7. Reid IR, Ames R, Evans MC, Sharpe S, Gamble G, France JT, et al. Determinants of total body and regional bone mineral density in normal postmenopausal women-a key role for fat mass. J Clin Endocrinol Metab 1992;75:45-51.
8. Kontogianni MD, Dafni UG, Routsias JG, Skopouli FN. Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res 2004;19:546-51.
9. Lenchik L, Register TC, Hsu FC, Lohman K, Nicklas BJ, Freedman BI, et al. Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone 2003;33:646-51.
10. Díez JJ, Iglesias P. The role of the novel adipocytederived hormone adiponectin in human disease. Eur J Endocrinol 2003;148:293-300.
11. Huang KC, Cheng WC, Yen RF, Tsai KS, Tai TY, Yang WS. Lack of independent relationship between plasma adiponectin, leptin levels and bone density in nondiabetic female adolescents. Clin Endocrinol (Oxf) 2004;61:204-8.
12. Jürimäe J, Rembel K, Jürimäe T, Rehan M. Adiponectin is associated with bone mineral density in perimenopausal women. Horm Metab Res 2005;37:297-302.
13. Kleerekoper M, Nelson DA, Peterson EL, Wilson PS, Jacobsen G, Longcope C. Body composition and gonadal steroids in older white and black women. J Clin Endocrinol Metab 1994;79:775-9.
14. Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone 2004;35:842-9.
15. Tsao TS, Murrey HE, Hug C, Lee DH, Lodish HF. Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem 2002;277:29359-62.
16. Oshima K, Nampei A, Matsuda M, Iwaki M, Fukuhara A, Hashimoto J, et al. Adiponect in increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 2005; 331:520-6.

APA	ÖZKURT B, ÖZKURT Z, Altay M, AKTEKİN C, ÇAĞLAYAN O, TABAK Y (2009). The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. , 78 - 84.
Chicago	ÖZKURT Bülent,ÖZKURT Zübeyde Nur,Altay Murat,AKTEKİN Cem Nuri,ÇAĞLAYAN Osman,TABAK Yalçın The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. (2009): 78 - 84.
MLA	ÖZKURT Bülent,ÖZKURT Zübeyde Nur,Altay Murat,AKTEKİN Cem Nuri,ÇAĞLAYAN Osman,TABAK Yalçın The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. , 2009, ss.78 - 84.
AMA	ÖZKURT B,ÖZKURT Z,Altay M,AKTEKİN C,ÇAĞLAYAN O,TABAK Y The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. . 2009; 78 - 84.
Vancouver	ÖZKURT B,ÖZKURT Z,Altay M,AKTEKİN C,ÇAĞLAYAN O,TABAK Y The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. . 2009; 78 - 84.
IEEE	ÖZKURT B,ÖZKURT Z,Altay M,AKTEKİN C,ÇAĞLAYAN O,TABAK Y "The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women." , ss.78 - 84, 2009.
ISNAD	ÖZKURT, Bülent vd. "The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women". (2009), 78-84.

APA	ÖZKURT B, ÖZKURT Z, Altay M, AKTEKİN C, ÇAĞLAYAN O, TABAK Y (2009). The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), 20(2), 78 - 84.
Chicago	ÖZKURT Bülent,ÖZKURT Zübeyde Nur,Altay Murat,AKTEKİN Cem Nuri,ÇAĞLAYAN Osman,TABAK Yalçın The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) 20, no.2 (2009): 78 - 84.
MLA	ÖZKURT Bülent,ÖZKURT Zübeyde Nur,Altay Murat,AKTEKİN Cem Nuri,ÇAĞLAYAN Osman,TABAK Yalçın The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), vol.20, no.2, 2009, ss.78 - 84.
AMA	ÖZKURT B,ÖZKURT Z,Altay M,AKTEKİN C,ÇAĞLAYAN O,TABAK Y The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.). 2009; 20(2): 78 - 84.
Vancouver	ÖZKURT B,ÖZKURT Z,Altay M,AKTEKİN C,ÇAĞLAYAN O,TABAK Y The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.). 2009; 20(2): 78 - 84.
IEEE	ÖZKURT B,ÖZKURT Z,Altay M,AKTEKİN C,ÇAĞLAYAN O,TABAK Y "The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women." Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), 20, ss.78 - 84, 2009.
ISNAD	ÖZKURT, Bülent vd. "The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women". Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) 20/2 (2009), 78-84.