Yeni keşif nöropeptitlerden: Oreksin

Gezmen Karadağ, Makbule; Aksoy, Meral

Yeni keşif nöropeptitlerden: Oreksin

MAKBULE GEZMEN KARADAĞ, (Hacettepe Üniversitesi, Tıp Fakültesi, Erişkin Hastanesi, Diyet ve Beslenme Bölümü, Ankara, Türkiye)

Meral AKSOY (Hacettepe Üniversitesi, Tıp Fakültesi, Erişkin Hastanesi, Diyet ve Beslenme Bölümü, Ankara, Türkiye)

Göztepe Tıp Dergisi

5 2

Yıl: 2009 Cilt: 24 Sayı: 2 Sayfa Aralığı: 79 - 87 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Yeni keşif nöropeptitlerden: Oreksin

Öz:

Oreksin A ve oreksin B tekli öncü polipeptit olan ve 130 amino asit içeren pre-pro oreksinden üremektedir. Pre-pro oreksin hipotalamusda ve daha az olmakla birlikte testis ve adrenal bezde bulunmaktadır. Oreksin-A ve oreksin-B ise merkezi sinir siteminde bulunmasının yanı sıra, adrenal bez ve ince bağırsak gibi ekstrahipotalamik bölgelerde de bulunmaktadır. Oreksin-A reseptörü (OX1) hipotalamus ve locus coeruleus ile diğer beyin bölgeleri ve spinal cord’da, Oreksin-B reseptörü (OX2) ise hipotalamus, korteks, spinal cord ve bazı nükleilerde eksprese olmaktadır. Aynı zamanda her iki reseptör de barsaklarda ekspire olmabilmektedir. Oreksinler yeme-içme davranışında, enerji homestazında, uyku/uyanıklık regülasyonunda görev almakla birlikte kardiyovasküler ve nöroendokrin sistem üzerine de etki etmektedirler. Bu yazı, oreksinlerin yerleşimi, farmakolojisi ve fizyolojik olaylardaki rollerini özetlemek amacıyla derlenmiştir.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

New discovery neuropeptides: Orexin

Öz:

Orexin A and orexin B are two peptides derived by proteolytic cleavage from a 130 amino acid precursor prepro-orexin. Pre-pro orexin is found in the hypothalamus and, to a markedly lesser extent, the testes and adrenals. However orexin-A and orexin-B are found in throught the central neural system, due to extrahypothalamic projectons, as well as in the adrenals and small intestine. The orexin-A receptor (OX1) is exspresses mainly in the hypothalamus and locus coeruleus, as well as other brain regions and the spinal cord. The orexin-B receptor (OX2) is expressed in the hypothalamus, cortex, spinal cord, and a few discrete bain nuclei. Both receptors are also expressed in the gut. The orexins modulate feding behaviour and energy homeostasis, as well as associated drinking behaviours, and also regulate sleep/ wake cycle. The orexins also have cardiovascular and neuroendocrine effects. This review is aimed to the pharmacology and localisation of these peptides and summarises the evidence of their role in physiology.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Gezmen Karadağ M, Aksoy M (2009). Yeni keşif nöropeptitlerden: Oreksin. , 79 - 87.
Chicago	Gezmen Karadağ Makbule,Aksoy Meral Yeni keşif nöropeptitlerden: Oreksin. (2009): 79 - 87.
MLA	Gezmen Karadağ Makbule,Aksoy Meral Yeni keşif nöropeptitlerden: Oreksin. , 2009, ss.79 - 87.
AMA	Gezmen Karadağ M,Aksoy M Yeni keşif nöropeptitlerden: Oreksin. . 2009; 79 - 87.
Vancouver	Gezmen Karadağ M,Aksoy M Yeni keşif nöropeptitlerden: Oreksin. . 2009; 79 - 87.
IEEE	Gezmen Karadağ M,Aksoy M "Yeni keşif nöropeptitlerden: Oreksin." , ss.79 - 87, 2009.
ISNAD	Gezmen Karadağ, Makbule - Aksoy, Meral. "Yeni keşif nöropeptitlerden: Oreksin". (2009), 79-87.

APA	Gezmen Karadağ M, Aksoy M (2009). Yeni keşif nöropeptitlerden: Oreksin. Göztepe Tıp Dergisi, 24(2), 79 - 87.
Chicago	Gezmen Karadağ Makbule,Aksoy Meral Yeni keşif nöropeptitlerden: Oreksin. Göztepe Tıp Dergisi 24, no.2 (2009): 79 - 87.
MLA	Gezmen Karadağ Makbule,Aksoy Meral Yeni keşif nöropeptitlerden: Oreksin. Göztepe Tıp Dergisi, vol.24, no.2, 2009, ss.79 - 87.
AMA	Gezmen Karadağ M,Aksoy M Yeni keşif nöropeptitlerden: Oreksin. Göztepe Tıp Dergisi. 2009; 24(2): 79 - 87.
Vancouver	Gezmen Karadağ M,Aksoy M Yeni keşif nöropeptitlerden: Oreksin. Göztepe Tıp Dergisi. 2009; 24(2): 79 - 87.
IEEE	Gezmen Karadağ M,Aksoy M "Yeni keşif nöropeptitlerden: Oreksin." Göztepe Tıp Dergisi, 24, ss.79 - 87, 2009.
ISNAD	Gezmen Karadağ, Makbule - Aksoy, Meral. "Yeni keşif nöropeptitlerden: Oreksin". Göztepe Tıp Dergisi 24/2 (2009), 79-87.