Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD

BARTU, Sevgi Saryal; YILDIZ, Öznur Akkoca; SEN, ELIF; KÖSE, Kenan

Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD

Elif ŞEN, (Ankara Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Sevgi Saryal BARTU, (Ankara Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Öznur Akkoca YILDIZ, (Ankara Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Kenan KÖSE (Ankara Üniversitesi, Tıp Fakültesi, Bioistatistik Anabilim Dalı, Ankara, Türkiye)

Türk Toraks Dergisi

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Yıl: 2009 Cilt: 10 Sayı: 3 Sayfa Aralığı: 122 - 129 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD

Öz:

Amaç: Torasik gaz kompresyonunun (TGK) ekspiratuar akım üzerine olumsuz etkisi vardır. Kronik obstrüktif akciğer hastalığı (KOAH) olan hastalarda TGK yüksektir.Bronkodilatörler hava yolu direncini azaltarak ve maksimal ekspiratuar akımı iyileştirerek torasik gaz kompresyonunu etkileyebilir.Bu çalışmanın amacı uzun etkili bronkodilatörlerin (formoterol 12 μg ve tiotropium 18 μg) KOAH'lı hastalarda torasik gaz kompresyonu, ağızda ve pletismografta ölçülen zorlu ekspiratuar volümlerine etkilerini araştırmaktı.Gereç ve Yöntem: KOAH'lı 40 hastada, ağızdan (m) ve pletismograftan (p) ölçülen maksimum ekspiratuar akım-volüm eğrilerini kullanarak formoterol ve tiotropiuma bronkodilatör yanıt değerlendirildi. Kompresyon volümü (V Comp= ΔV akciğer - ΔV ağız) elde edildi.Bulgular: Bazal, 30., 60. ve 120. dakikalarda tekrarlanan ölçümler yapıldı. Formoterol ve tiotropiumun belirgin bronkodilatör etkisi oldu ve formoterol tiotropiumla karşılaştırıldığında FEV1 m'de daha fazla (p<0.001) artış oluşturdu.Torasik gaz kompresyon volümleri KOAH'lı hastalarda her iki uzun etkili bronkodilatörden sonra anlamlı olarak değişmedi. Vital kapasitenin %25, 50 ve 75'inde (Vcomp25, Vcomp50, Vcomp75) torasik gaz kompresyon volümlerinde iki ilaç arasında belirgin farklılık bulunmadı. Torasik gaz kompresyon volümleri evre II–III ve IV KOAH'lı hastalar arasında farklılık göstermedi.Sonuç: Bu çalışmanın sonuçları her iki çalışma ilacının spirometrik ölçümlerde anlamlı bronkodilatör etki göstermekle birlikte torasik gaz kompresyon volümlerinin uzun etkili bronkodilatör verilmesinden sonar belirgin olarak değişmediğini ve hastalık şiddetinin uzun etkili bronkodilatör ilaçların torasik gaz kompresyon volümlerine olan etkisini değiştirmediğini düşündürmektedir.

Anahtar Kelime: Bronkodilatör ajanlar formoterol tiotropiyum Akciğer hastalığı, kronik obstrüktif Pletismografi

Konular: Solunum Sistemi Kulak, Burun, Boğaz

KOAH'lı hastalarda uzun etkili bronkodilatörlerin torasik gaz kompresyonuna akut etkileri

Öz:

Objective: Thoracic gas compression (TGC) has a negative effect on expiratory flow. In patients with chronic obstructive pulmonary disease (COPD), TGC is high. Bronchodilators may affect thoracic gas compression by reducing airway resistance and improve maximal expiratory flow. The aim of this study was to investigate the effects of long-acting bronchodilators (formoterol 12 μg and tiotropium 18 μg) on thoracic gas compression, forced expiratory volumes measured at the mouth and in a plethysmograph in patients with COPD.Material and Method: Bronchodilator response to formoterol and tiotropium was assessed in 40 COPD patients using maximum expiratory flow-volume curve values measured at the mouth (m) and plethysmograph (p). Volume of compression (V Comp= ΔV lung - ΔV mouth) was obtained.Results: The repeated measurements were performed at baseline, 30., 60. and 120. minutes. Formoterol and tiotropium had significant bronchodilator effects, and formoterol produced a higher increase in FEV1 m (p<0,001) compared to tiotropium. Thoracic gas compression volumes did not change significantly after either long-acting bronchodilator administration in patients with COPD. With regard to thoracic gas compression volume at 25, 50 and 75 % of VC (Vcomp25, Vcomp50, Vcomp75, no relevant difference was found between the two drugs. The thoracic gas compression volumes did not differ between stage II–III and stage IV COPD patients.Conclusion: The results of this study suggest that thoracic gas compression volume did not change significantly after administration of long-acting bronchodilators, even if both study drugs elicited significant bronchodilation in spirometric measurements, and the disease severity did not influence the effect of the long acting bronchodilator agents on thoracic gas compression volumes.

Anahtar Kelime: Pulmonary Disease, Chronic Obstructive Plethysmography Bronchodilator Agents formoterol tiotropium

Konular: Solunum Sistemi Kulak, Burun, Boğaz

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SEN E, BARTU S, YILDIZ Ö, KÖSE K (2009). Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. , 122 - 129.
Chicago	SEN ELIF,BARTU Sevgi Saryal,YILDIZ Öznur Akkoca,KÖSE Kenan Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. (2009): 122 - 129.
MLA	SEN ELIF,BARTU Sevgi Saryal,YILDIZ Öznur Akkoca,KÖSE Kenan Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. , 2009, ss.122 - 129.
AMA	SEN E,BARTU S,YILDIZ Ö,KÖSE K Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. . 2009; 122 - 129.
Vancouver	SEN E,BARTU S,YILDIZ Ö,KÖSE K Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. . 2009; 122 - 129.
IEEE	SEN E,BARTU S,YILDIZ Ö,KÖSE K "Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD." , ss.122 - 129, 2009.
ISNAD	SEN, ELIF vd. "Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD". (2009), 122-129.

APA	SEN E, BARTU S, YILDIZ Ö, KÖSE K (2009). Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. Türk Toraks Dergisi, 10(3), 122 - 129.
Chicago	SEN ELIF,BARTU Sevgi Saryal,YILDIZ Öznur Akkoca,KÖSE Kenan Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. Türk Toraks Dergisi 10, no.3 (2009): 122 - 129.
MLA	SEN ELIF,BARTU Sevgi Saryal,YILDIZ Öznur Akkoca,KÖSE Kenan Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. Türk Toraks Dergisi, vol.10, no.3, 2009, ss.122 - 129.
AMA	SEN E,BARTU S,YILDIZ Ö,KÖSE K Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. Türk Toraks Dergisi. 2009; 10(3): 122 - 129.
Vancouver	SEN E,BARTU S,YILDIZ Ö,KÖSE K Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD. Türk Toraks Dergisi. 2009; 10(3): 122 - 129.
IEEE	SEN E,BARTU S,YILDIZ Ö,KÖSE K "Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD." Türk Toraks Dergisi, 10, ss.122 - 129, 2009.
ISNAD	SEN, ELIF vd. "Acute effect of long-acting bronchodilators on thoracic gas compression in patients with COPD". Türk Toraks Dergisi 10/3 (2009), 122-129.