Effect of chronic high dose-alcohol consumption on the general biochemical parameters

TUNÇEL, Özgür K.; ANKARALI, Seyit; TOMAK, LEMAN; Amanvermez, Ramazan; ALVUR, Muhlie

Effect of chronic high dose-alcohol consumption on the general biochemical parameters

Ramazan AMANVERMEZ, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Samsun, Türkiye)

Seyit ANKARALI, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Samsun, Türkiye)

Özgür K. TUNÇEL, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Samsun, Türkiye)

Leman TOMAK, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Samsun, Türkiye)

Muhlie ALVUR (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Samsun, Türkiye)

Türk Biyokimya Dergisi

2 0

Yıl: 2009 Cilt: 34 Sayı: 3 Sayfa Aralığı: 113 - 120 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Effect of chronic high dose-alcohol consumption on the general biochemical parameters

Öz:

Amaç: Kronik yüksek doz alkol alımı vücutta oksidatif stres, metabolik anormallikler ve besinsel eksikliklere sebep olabilir. Uzun dönem alkol içilmesinde, biyokimyasal parametrelere alkol tüketiminin etkisi yeterince açıklanmamıştır.Gereç ve Yöntem: Dişi ve erkek ratlar; I. Kontrol (n=7), II. Alkol (2.5 g/k %50etanol bir gün ara ile intragastrik verildi; insanlardaki karşılığı 60 kg için ~750 g)alan grup (n=6) olarak 90 günlük periyod dahilinde bakıldı. Bu periyodik süre sonunda; rat serum veya plazmasında kimyasal, elektrolit, lipid, demir ve enzimatiktest analizleri Roche kitlerin kullanıldığı otomatik analizör ile yapıldı (toplam 30biyokimyasal parametre).Bulgular: Albumin ve demir düzeyleri kontrol dişi ratlara kıyasla alkol alan dişiratlarda azaldı, fakat total demir bağlama kapasitesi ve sodyum düzeyleri alkolverilen grupta arttı. Laktat, sodyum, total ve pankreatik amilaz, γ-glutamil transferaz, glukoz ve total kolesterol düzeyleri kontrol grubuna kıyasla alkol alan erkekratlarda yüksek bulundu. Ortalama alkol düzeyi kontrol ratlara kıyasla dişi ratlarda%40, erkek ratlarda ise %26.6 yükselmiş bulundu. Ancak gruplar arasında anlamlıistatistiksel bir fark yoktu.Sonuçlar: Alkolizm patogenezinde her iki eşeyde kronik yüksek doz etanolalımına bağlı toksisite etkisiyle bazı kimyasal parametreler ve bir grup test düzeyleri değişebilir.

Anahtar Kelime:

Konular: Biyokimya ve Moleküler Biyoloji

Kronik yüksek doz-alkol tüketiminin genel biyokimyasal parametrelere etkisi

Öz:

Objectives: A chronic intake of high dose alcohol may cause oxidative stress, metabolic abnormalities and nutritional deficiencies in the body. The effect of long-termalcohol consumption on the biochemical parameters has not been explained well. Materials and Methods: Female and male rats were maintained for 90 days asfollow: I. Control (n=7), II. Alcohol-treated (2.5 gr of 50% ethanol/kg body wt administered intragastrically every other day; human equivalent is ~750 gr alcoholfor 60 kg) group (n=6). At the end of treatment period; chemical, electrolyte, lipid,iron and enzymatic test analyses were measured by automated analyzer with Rochediagnostic kits in the rat serum or plasma.Results: Albumin and iron levels were decreased in the alcohol-treated female ratsas compared to the control female rats, but total iron binding capacity and sodiumlevels were increased in the alcohol-treated group. Lactate, sodium, total and pancreatic amylase, γ-glutamyl transferase, glucose and total cholesterol levels wereelevated in the alcohol-treated male rats as compared to the control rats. Mean alcohol level was raised by 40% in the female and 26.6% in the male alcohotreatedrats compared to control rats, but there was no statistically significant differencebetween groups. Conclusions: Some chemical parameters and a group of test values due to ethanoltoxicity in both sexes fed chronically with high dose of alcohol may alter in thepathogenesis of alcoholism.

Anahtar Kelime:

Konular: Biyokimya ve Moleküler Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Amanvermez R, ANKARALI S, TUNÇEL Ö, TOMAK L, ALVUR M (2009). Effect of chronic high dose-alcohol consumption on the general biochemical parameters. , 113 - 120.
Chicago	Amanvermez Ramazan,ANKARALI Seyit,TUNÇEL Özgür K.,TOMAK LEMAN,ALVUR Muhlie Effect of chronic high dose-alcohol consumption on the general biochemical parameters. (2009): 113 - 120.
MLA	Amanvermez Ramazan,ANKARALI Seyit,TUNÇEL Özgür K.,TOMAK LEMAN,ALVUR Muhlie Effect of chronic high dose-alcohol consumption on the general biochemical parameters. , 2009, ss.113 - 120.
AMA	Amanvermez R,ANKARALI S,TUNÇEL Ö,TOMAK L,ALVUR M Effect of chronic high dose-alcohol consumption on the general biochemical parameters. . 2009; 113 - 120.
Vancouver	Amanvermez R,ANKARALI S,TUNÇEL Ö,TOMAK L,ALVUR M Effect of chronic high dose-alcohol consumption on the general biochemical parameters. . 2009; 113 - 120.
IEEE	Amanvermez R,ANKARALI S,TUNÇEL Ö,TOMAK L,ALVUR M "Effect of chronic high dose-alcohol consumption on the general biochemical parameters." , ss.113 - 120, 2009.
ISNAD	Amanvermez, Ramazan vd. "Effect of chronic high dose-alcohol consumption on the general biochemical parameters". (2009), 113-120.

APA	Amanvermez R, ANKARALI S, TUNÇEL Ö, TOMAK L, ALVUR M (2009). Effect of chronic high dose-alcohol consumption on the general biochemical parameters. Türk Biyokimya Dergisi, 34(3), 113 - 120.
Chicago	Amanvermez Ramazan,ANKARALI Seyit,TUNÇEL Özgür K.,TOMAK LEMAN,ALVUR Muhlie Effect of chronic high dose-alcohol consumption on the general biochemical parameters. Türk Biyokimya Dergisi 34, no.3 (2009): 113 - 120.
MLA	Amanvermez Ramazan,ANKARALI Seyit,TUNÇEL Özgür K.,TOMAK LEMAN,ALVUR Muhlie Effect of chronic high dose-alcohol consumption on the general biochemical parameters. Türk Biyokimya Dergisi, vol.34, no.3, 2009, ss.113 - 120.
AMA	Amanvermez R,ANKARALI S,TUNÇEL Ö,TOMAK L,ALVUR M Effect of chronic high dose-alcohol consumption on the general biochemical parameters. Türk Biyokimya Dergisi. 2009; 34(3): 113 - 120.
Vancouver	Amanvermez R,ANKARALI S,TUNÇEL Ö,TOMAK L,ALVUR M Effect of chronic high dose-alcohol consumption on the general biochemical parameters. Türk Biyokimya Dergisi. 2009; 34(3): 113 - 120.
IEEE	Amanvermez R,ANKARALI S,TUNÇEL Ö,TOMAK L,ALVUR M "Effect of chronic high dose-alcohol consumption on the general biochemical parameters." Türk Biyokimya Dergisi, 34, ss.113 - 120, 2009.
ISNAD	Amanvermez, Ramazan vd. "Effect of chronic high dose-alcohol consumption on the general biochemical parameters". Türk Biyokimya Dergisi 34/3 (2009), 113-120.