Yıl: 2009 Cilt: 33 Sayı: 4 Sayfa Aralığı: 301 - 306 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi

Öz:
Paraziter enfeksiyonlar tüm dünyada tıbbi ve ekonomik etkilere yol açmaktadır. Parazite ve T hücreleri ile sitokinler gibi konağa ait çeşitli faktörler, enfeksiyonların ilerleyişi ve sonucu üzerinde önemli etkilere sahiptir. Bu derlemede paraziter enfeksiyonları kontrol eden, hücresel immun yanıtları düzenleyen sitokin ilişkili negatif regülatör mekanizmalar tartışılmıştır.
Anahtar Kelime: Sitokinler Paraziter hastalıklar T-lenfositleri Bağışıklık, hücresel Sinyal transdüksiyonu

Konular: Mikrobiyoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji

Cytokine related intracellular signal transduction and consequences in parasitic infections

Öz:
Parasitic diseases have worldwide medical and economical consequences. A variety of parasite and host factors such as host T lymphocytes and cytokines have a strong impact on the outcome of parasitic infections. In this review we discussed how negative regulatory mechanisms of cytokine related intracellular signals attenuation are essential for ensuring and appropriate, controlled cellular immune response on parasitic infections.
Anahtar Kelime: Immunity, Cellular Signal Transduction Cytokines Parasitic Diseases T-Lymphocytes

Konular: Mikrobiyoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1) Alexander J, Bryson K, 2005. T helper (h)1/Th2 and Leishmania: paradox rather than paradigm. Immunol Lett, 99 (1): 17-23.
  • 2) Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TW, Nicola NA, Hertzog PJ, Metcalf D, Hilton DJ, 1999. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell, 98: 597–608.
  • 3) Asirvatham AJ, Magner WJ, Tomasi TB, 2009. miRNA regulation of cytokine genes. Cytokine, 45: 2, 58-69.
  • 4) Baker BJ, Akhtar LN and Benveniste EN, 2009. SOCS1 and SOCS3 in the control of CNS immunity. Trends Immunol, 30: 392-400.
  • 5) Bayram Delibaş S, Turgay N, Gürüz AY, 2009. Role of cytokines in the immunopathogenesis of toxoplasmosis. Turkiye Klinikleri J Med Sci, 29(5): 1217-1221.
  • 6) Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL, 2002. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature, 420: 502–507.
  • 7) Bertholet S, Dickensheets HL, Sheikh F, Gam AA, Donnelly RP, Kenney RT, 2003. Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation. Infect Immun, 71: 2095–2101.
  • 8) Blanchette J, Racette N, Faure R, Siminovitch KA, Olivier M, 1999. Leishmania-induced increases in activation of macrophages SHP-I tryrosine phosphatase are associated with impaired IFN-γ triggered Jak2 activation. Eur J Immunol, 29: 3737-3744.
  • 9) Bullen DVR, Baldwin TM, Curtis JM, Alexander WS, Handman E, 2003. Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. J Immunol, 170: 4267–4272.
  • 10) Butcher BA, Kim L, Johnson PF, Denkers EY, 2001. Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kappa B. J Immunol, 167: 2193–2201.
  • 11) Butcher BA, Kim L, Panıpoulos AD, Watowich SS, Murray PJ, Denkers EY, 2005. IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNFalpha in host macrophages. J Immunol, 174: 3148–3152.
  • 12) Campbell IL, 2005. Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS. Brain Res Rev, 48: 2, 166-177.
  • 13) Casanova JL, Abel L, 2004. The human model: a genetic dissection of immunity to infection in natural conditions. Nat Rev Immun, 4: 55–66.
  • 14) Cerávolo IP, Chaves ACL, Bonjardim CA, Sibley D, Romanha AJ, Gazzinelli RT, 1999. Replication of Toxoplasma gondii, but not Trypanosoma cruzi, is regulated in human fibroblasts activated with gamma interferon: requirement of a functional JAK/STAT pathway. Infec Immun, 67 (5): 2233-2240.
  • 15) Chelbi-Alix MK, Wietzerbin J, 2007. Interferon, a growing cytokine family: 50 years of interferon research. Biochimie, 89: 6-7, 713-718.
  • 16) Croker BA, Kiu H, Nicholson S, 2008. SOCS regulation of the JAK/STAT signalling pathway. Cell Dev Biol, 19(4): 414-422.
  • 17) Dalpke A, Heeg K, Bartz H, Baetz A, 2008. Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins. Immunobiology, 213: 3-4, 225-235.
  • 18) Doerig C, Billker O, Haystead T, Sharma P, Tobin AB, Waters NC, 2008. Protein kinases of malaria parasites: an update. Trends Parasitol, 24 (12): 570-577.
  • 19) DosReis GA, Ribeiro-Gomes FL, Guillermo LVC, Lopes MF, 2007. Cross-talk between apoptosis and cytokines in the regulation of parasitic infection. Cytokine Growth Factor Rev, 18: 1-2, 97-105.
  • 20) Durbin JE, Hackenmiller R, Simon MC, Levy DE, 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell, 84: 443–450.
  • 21) Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A, 1997. A new protein containing an SH2 domain that inhibits JAK kinases. Nature, 387: 921–924.
  • 22) Flohr C, Quinnell RJ, Britton J, 2009. Do helminth parasites protect against atopy and allergyic disease? Clin Exp Allergy, 39 (1): 20-32.
  • 23) Forget G, Siminovitch KA, Brochu SRS, Radzioch D and Olivier M, 2001. Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis. Eur J Immunol, 31: 3185–3196.
  • 24) Fujimoto M, Tsutsui H, Yumikura-Futatsugi S, Ueda H, Xingshou O, Abe T, Kawase I, Nakanishi K, Kishimoto T, Naka T, 2002. A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo. Int Immunol, 14: 1343– 1350.
  • 25) Gregory DJ, Godbout M, Contreras I, Forget G, Olivier M, 2008. A novel form of NF-κB is induced by Leishmania infection: involvement in macrophages gene expression, Eur J Immunol, 38: 1071–1081.
  • 26) Hao XR, Cao DL, Hu YW, Li XX, Liu XH, Xiao J, Liao DF, Xiang J, Tang CK, 2009. IFN-γ down-regulates ABCA1 expression by inhibiting LXRα in a JAK/STAT signaling pathway-dependent manner. Atherosclerosis, 203: 2, 417-428.
  • 27) Imitola J, Chitnis T, Khoury SJ, 2005. Cytokines in multiple sclerosis: from bench to bedside. Pharmacol Ther, 106: 163-177.
  • 28) Jang HD, Yoon K, Shin YJ, Kim J, Lee SY, 2004. PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit. J Biol Chem, 279: 24873–24880.
  • 29) Liu B, Yang Y, Chernishof V, Loo RR, Jang H, Tahk S, Yang R, Mink S, Shultz D, Bellone CJ, Loo JA, Shuai K, 2007. Proinflammatory Stimuli Induce IKKα-Mediated Phosphorylation of PIAS1 to Restrict Inflammation and Immunity. Cell, 129: 5,903-914.
  • 30) Lüder CGK, Stanway RR, Chaussepied M, Langsley G, Heussler VT, 2009. Intracellular survival of apicomplexan parasites and host cell modification. Int J Parasitol, 39: 2, 163-173.
  • 31) Maine GN, Mao X, Komarck CM, Burstein E, 2007. COMMD1 promotes the ubiquitination of NFκB subunits through a cullin-containing ubiquitin ligase. EMBO J., 26: 436–447.
  • 32) Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD, 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAKSTAT signaling pathway. Cell, 84: 431–442.
  • 33) Murray HW, Berman JD, Davies CR and Saravia NG, 2005. Advances in leishmaniasis. Lancet, 366: 1561–1577.
  • 34) Nandan D, Reiner NE, 2005. Leishmania donovani engages in regulatory interference by targeting macrophage protein tyrosine phosphatase SHP-1. Clin Immunol, 114: 3, 266-277.
  • 35) Ortmann RA, Cheng T, Visconti R, Frucht DM, O'Shea JJ, 2000. Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation. Arthritis Res, 2: 16–32.
  • 36) Özcel MA, 2007. “İmmunoparazitolojiye giriş”. Tıbbi ve Veteriner İmmunoparazitoloji; editörler, Özcel MA, İnci A, Turgay N ve Köroğlu E, 5-18, Türkiye Parazitoloji Derneği Yayınları No: 21, İzmir.
  • 37) Park C, Cha SLE, Schindler C, 2000. Immune response in Stat2 knockout mice. Immunity, 13: 795–804.
  • 38) Rakesh K, Agrawal DK, 2005. Controlling cytokine signaling by constitutive inhibitors. Biochem Pharmacol, 70: 5, 649-657.
  • 39) Sacks D, Sher A, 2002. Evasion of innate immunity by parasitic protozoa. Nature Immunol, 3 (11): 1041-1047.
  • 40) Scott P, 2003. Development and regulation of cell-mediated immunity in experimental leishmaniasis. Immunol Res, 27 (2-3): 489-498.
  • 41) Sharrocks AD, 2006. PIAS proteins and transcriptional regulation–more than just SUMO E3 ligases? Genes Dev, 20: 754–758.
  • 42) Shuai K, Liu B, 2003. Regulation of JAK-STAT signaling in the immune system. Nat Rev Immunol, 3: 900–911.
  • 43) Shuai K, Liu B, 2005. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat Rev Immunol, 5: 593–605.
  • 44) Suzuki Y, 1999. Genes, cells and cytokines in resistance against development of toxoplasmic encephalitis. Immunobiology, 201: 255–271.
  • 45) Turgay N, 2007. “Leishmaniosis ve İmmunolojisi”. Tıbbi ve Veteriner İmmunoparazitoloji; editörler, Özcel MA, İnci A, Turgay N ve Köroğlu E, 155-167, Türkiye Parazitoloji Derneği Yayınları No: 21, İzmir.
  • 46) Turgay N, Delibaş SB, Erdoğan DD, Özbel Y, 2006. Şanlıurfa'da Antroponotik kutanöz leishmaniasis hastalarının hücresel immun cevabı. Turkiye Parazitol Derg, 30(1): 7-10.
  • 47) Ustun S, Turgay N, Delibas SB, Ertabaklar H, 2004. Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases. World J Gastroenterol, 10 (24): 3643.
  • 48) Viviani B, Bartesaghi S, Corsini E, Galli CL, Marinovich M, 2004. Cytokines role in neurodegenerative events. Toxicol Lett, 149: 85-89.
  • 49) Wu C, Sun M, Liu L, Zhou GW, 2003. The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene,13: 306, 1–12.
  • 50) Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A, 1999. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J, 18: 1309–1320.
  • 51) Yılmaz O, Önal A, Gökçay F, 2009. Nörodejeneratif süreçler ve ağrıda immunomodulasyon. Ayın Kitabı 108. Ege Üniversitesi Basımevi, İzmir (baskıda).
  • 52) Yilmaz O, Taskiran D, Aydar S, 2004. Cytotoxicity in cytokine stimulated astrocyte cultures: role of IL-6 and nitric oxide. Neurosci Res Commun, 34: 2, 82-91.
  • 53) Zhang Q, Putheti P, Zhou Q, Liu Q, Wenda G, 2008. Structures and biological functions of IL-31 and IL-31 receptors. Cytokine Growth Factor Rev, 19 (5-6): 347-356.
  • 54) Zimmermann S, Murray PJ, Heeg K, Dalpke AH, 2006. Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. J Immunol, 176: 1840–1847.
APA Yilmaz O, TURGAY N (2009). Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. , 301 - 306.
Chicago Yilmaz Ozlem,TURGAY NEVIN Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. (2009): 301 - 306.
MLA Yilmaz Ozlem,TURGAY NEVIN Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. , 2009, ss.301 - 306.
AMA Yilmaz O,TURGAY N Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. . 2009; 301 - 306.
Vancouver Yilmaz O,TURGAY N Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. . 2009; 301 - 306.
IEEE Yilmaz O,TURGAY N "Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi." , ss.301 - 306, 2009.
ISNAD Yilmaz, Ozlem - TURGAY, NEVIN. "Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi". (2009), 301-306.
APA Yilmaz O, TURGAY N (2009). Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. Türkiye Parazitoloji Dergisi, 33(4), 301 - 306.
Chicago Yilmaz Ozlem,TURGAY NEVIN Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. Türkiye Parazitoloji Dergisi 33, no.4 (2009): 301 - 306.
MLA Yilmaz Ozlem,TURGAY NEVIN Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. Türkiye Parazitoloji Dergisi, vol.33, no.4, 2009, ss.301 - 306.
AMA Yilmaz O,TURGAY N Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. Türkiye Parazitoloji Dergisi. 2009; 33(4): 301 - 306.
Vancouver Yilmaz O,TURGAY N Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi. Türkiye Parazitoloji Dergisi. 2009; 33(4): 301 - 306.
IEEE Yilmaz O,TURGAY N "Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi." Türkiye Parazitoloji Dergisi, 33, ss.301 - 306, 2009.
ISNAD Yilmaz, Ozlem - TURGAY, NEVIN. "Sitokin ilişkili hücre içi sinyal iletimi ve paraziter enfeksiyonlardaki önemi". Türkiye Parazitoloji Dergisi 33/4 (2009), 301-306.