Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity

DEMİRBAŞ, Ahmet; DEMİRBAŞ, NESLİHAN; BEKTAŞ, Hakan; Alpay Karaoğlu, Şengül

Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity

Hakan BEKTAŞ, (Giresun Üniversitesi, Kimya Bölümü, Giresun, Türkiye)

Ahmet DEMİRBAŞ, (Karadeniz Teknik Üniversitesi, Fen Fakültesi, Kimya Bölümü, Giresun, Türkiye)

Neslihan DEMİRBAŞ, (Karadeniz Teknik Üniversitesi, Fen Fakültesi, Kimya Bölümü, Giresun, Türkiye)

ŞENGÜL ALPAY KARAOĞLU (Rize Üniversitesi, Rize, Türkiye)

Turkish Journal of Chemistry

1 0

Yıl: 2010 Cilt: 34 Sayı: 2 Sayfa Aralığı: 165 - 180 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity

Öz:

2-{3-(4-Substitutedbenzyl)-4-[2-(1H-indol-3-yl)ethyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N' -(arylmethylene) acetohydrazides (5a-g), 4-amino-2-{3-(4-substitutedbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1- yl}-N' -(arylmethylene)acetohydrazides (6a,b), and 4-[2-(1H-indol-3-yl)ethyl]-5-(4-substitutedbenzyl)-2-{[5- (phenylamino)-1,3,4-thiadiazol-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-ones (8a,b) were synthesized starting from 4-alkyl-5-(4-substitutedbenzyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones (2a-c) by several steps and their structures were well characterized by elemental analyses, IR, 1H-NMR, 13C-NMR, and mass spectral studies. They were also screened for their microbial activities. The obtained antimicrobial activity results revealed that 12 among the 24 compounds tested displayed variable growth inhibition effects on the tested grampositive and gram-negative bacterial strains. None of the compounds showed antifungal activity against yeast-like fungi.

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BEKTAŞ H, DEMİRBAŞ A, DEMİRBAŞ N, Alpay Karaoğlu Ş (2010). Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. , 165 - 180.
Chicago	BEKTAŞ Hakan,DEMİRBAŞ Ahmet,DEMİRBAŞ NESLİHAN,Alpay Karaoğlu Şengül Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. (2010): 165 - 180.
MLA	BEKTAŞ Hakan,DEMİRBAŞ Ahmet,DEMİRBAŞ NESLİHAN,Alpay Karaoğlu Şengül Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. , 2010, ss.165 - 180.
AMA	BEKTAŞ H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. . 2010; 165 - 180.
Vancouver	BEKTAŞ H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. . 2010; 165 - 180.
IEEE	BEKTAŞ H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş "Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity." , ss.165 - 180, 2010.
ISNAD	BEKTAŞ, Hakan vd. "Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity". (2010), 165-180.

APA	BEKTAŞ H, DEMİRBAŞ A, DEMİRBAŞ N, Alpay Karaoğlu Ş (2010). Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. Turkish Journal of Chemistry, 34(2), 165 - 180.
Chicago	BEKTAŞ Hakan,DEMİRBAŞ Ahmet,DEMİRBAŞ NESLİHAN,Alpay Karaoğlu Şengül Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. Turkish Journal of Chemistry 34, no.2 (2010): 165 - 180.
MLA	BEKTAŞ Hakan,DEMİRBAŞ Ahmet,DEMİRBAŞ NESLİHAN,Alpay Karaoğlu Şengül Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. Turkish Journal of Chemistry, vol.34, no.2, 2010, ss.165 - 180.
AMA	BEKTAŞ H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. Turkish Journal of Chemistry. 2010; 34(2): 165 - 180.
Vancouver	BEKTAŞ H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity. Turkish Journal of Chemistry. 2010; 34(2): 165 - 180.
IEEE	BEKTAŞ H,DEMİRBAŞ A,DEMİRBAŞ N,Alpay Karaoğlu Ş "Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity." Turkish Journal of Chemistry, 34, ss.165 - 180, 2010.
ISNAD	BEKTAŞ, Hakan vd. "Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity". Turkish Journal of Chemistry 34/2 (2010), 165-180.