Inclusion and release of theophylline from chitosan based microparticles

POPA, Niculina; NOVAC, Ovidiu; PROFIRE, Lenuta; HRITCU, Doina; POPA, Marcel Ionel

Inclusion and release of theophylline from chitosan based microparticles

Niculina POPA, (Technical Univercity Iasi, Faculty Chemical Engineering and Environmental Protection Bd D. Mangeron, 700050, Iasi, Romania)

Ovidiu NOVAC, (Technical Univercity Iasi, Faculty Chemical Engineering and Environmental Protection Bd D. Mangeron, 700050, Iasi, Romania)

Lenuta PROFIRE, (Univercity of Medicine and Pharmacy, “Gr. T. Popa”, Iasi, Romania)

Doina HRITCU, (Technical Univercity Iasi, Faculty Chemical Engineering and Environmental Protection Bd D. Mangeron, 700050, Iasi, Romania)

Marcel Ionel POPA (Technical Univercity Iasi, Faculty Chemical Engineering and Environmental Protection Bd D. Mangeron, 700050, Iasi, Romania)

Turkish Journal of Chemistry

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Yıl: 2010 Cilt: 34 Sayı: 2 Sayfa Aralığı: 255 - 262 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Inclusion and release of theophylline from chitosan based microparticles

Öz:

Chitosan (CS) based microparticles for controlled release of theophylline (THP) were obtained by ionic gelation. The microparticles were characterized by laser diffraction analysis (particle size), scanning electron microscopy (SEM), FTIR spectroscopy, and thermogravimetric analysis. The average diameter of the CSTHP microparticles was 182 μm. The FTIR spectra confirmed that new hydrogen bonds had formed between the carbonylic group belonging to THP and the amino group of CS, while the thermogravimetric analysis showed a modified stability in the obtained particles and confirmed the presence of an interaction between the drug and CS. The THP release process was monitored for up to 24 h in simulated gastric fluid (pH 1.5) and in simulated intestinal fluid (pH 7.4). The release process of THP from microparticles was not influenced by the pH of dissolution media. In the first 30 min the drug was released in a rapid manner, and after this stage by a non-Fickian profile.

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	POPA N, NOVAC O, PROFIRE L, HRITCU D, POPA M (2010). Inclusion and release of theophylline from chitosan based microparticles. , 255 - 262.
Chicago	POPA Niculina,NOVAC Ovidiu,PROFIRE Lenuta,HRITCU Doina,POPA Marcel Ionel Inclusion and release of theophylline from chitosan based microparticles. (2010): 255 - 262.
MLA	POPA Niculina,NOVAC Ovidiu,PROFIRE Lenuta,HRITCU Doina,POPA Marcel Ionel Inclusion and release of theophylline from chitosan based microparticles. , 2010, ss.255 - 262.
AMA	POPA N,NOVAC O,PROFIRE L,HRITCU D,POPA M Inclusion and release of theophylline from chitosan based microparticles. . 2010; 255 - 262.
Vancouver	POPA N,NOVAC O,PROFIRE L,HRITCU D,POPA M Inclusion and release of theophylline from chitosan based microparticles. . 2010; 255 - 262.
IEEE	POPA N,NOVAC O,PROFIRE L,HRITCU D,POPA M "Inclusion and release of theophylline from chitosan based microparticles." , ss.255 - 262, 2010.
ISNAD	POPA, Niculina vd. "Inclusion and release of theophylline from chitosan based microparticles". (2010), 255-262.

APA	POPA N, NOVAC O, PROFIRE L, HRITCU D, POPA M (2010). Inclusion and release of theophylline from chitosan based microparticles. Turkish Journal of Chemistry, 34(2), 255 - 262.
Chicago	POPA Niculina,NOVAC Ovidiu,PROFIRE Lenuta,HRITCU Doina,POPA Marcel Ionel Inclusion and release of theophylline from chitosan based microparticles. Turkish Journal of Chemistry 34, no.2 (2010): 255 - 262.
MLA	POPA Niculina,NOVAC Ovidiu,PROFIRE Lenuta,HRITCU Doina,POPA Marcel Ionel Inclusion and release of theophylline from chitosan based microparticles. Turkish Journal of Chemistry, vol.34, no.2, 2010, ss.255 - 262.
AMA	POPA N,NOVAC O,PROFIRE L,HRITCU D,POPA M Inclusion and release of theophylline from chitosan based microparticles. Turkish Journal of Chemistry. 2010; 34(2): 255 - 262.
Vancouver	POPA N,NOVAC O,PROFIRE L,HRITCU D,POPA M Inclusion and release of theophylline from chitosan based microparticles. Turkish Journal of Chemistry. 2010; 34(2): 255 - 262.
IEEE	POPA N,NOVAC O,PROFIRE L,HRITCU D,POPA M "Inclusion and release of theophylline from chitosan based microparticles." Turkish Journal of Chemistry, 34, ss.255 - 262, 2010.
ISNAD	POPA, Niculina vd. "Inclusion and release of theophylline from chitosan based microparticles". Turkish Journal of Chemistry 34/2 (2010), 255-262.