The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma

Ozdemir, Nezih; CANGIR, Ayten K.; DOĞAN, Rıza; Emri, Salih; akyol, fadıl; DEMİRKAZIK, Figen B.; ÖZYİĞİT, Gökhan; KARA, MURAT; SELEK, UGUR; TAŞTEPE, İrfan; Hurmuz, Pervin

The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma

Pervin HÜRMÜZ, (Hacettepe Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Fadıl AKYOL, (Hacettepe Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Uğur SELEK, (Hacettepe Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Gökhan ÖZYİĞİT, (Hacettepe Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Rıza DOĞAN, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, Ankara, Türkiye)

Nezih ÖZDEMİR, (Ankara Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, Ankara, Türkiye)

İrfan TAŞTEPE, (Atatürk Eğitim ve Araştırma Hastanesi, Göğüs Cerrahisi Kliniği, Ankara)

Ayten K. CANGIR, (Ankara Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, Ankara, Türkiye)

Murat KARA, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, Ankara, Türkiye)

Figen B. DEMİRKAZIK, (Hacettepe Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Ankara, Türkiye)

Salih EMRİ, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Diğer Yazarlar

Uluslararası Hematoloji-Onkoloji Dergisi

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Yıl: 2010 Cilt: 20 Sayı: 1 Sayfa Aralığı: 20 - 26 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma

Öz:

Bu çalışma kapsamında EPP sonrası üç boyutlu konformal eksternal radyoterapinin (3BKRT) etkinlik ve toksisitesinin değerlendirilmesi hedeflenmiştir. En sık görülen histopatoloji epitelyal tipti (%79). American Joint Commission on Cancer (AJCC) 2002 evreleme sistemine göre bir olgu (%7) evre I, 4 olgu (%29) evre II, 9 olgu (%64) evre III olarak kabul edildi. Hemitoraksa 1.8 Gy/ gün fraksiyon dozu ile toplam medyan 50.4 Gy 3BKRT uygulandı. Onbir hasta platin ve pemetreksed kombinasyonundan oluşan adjuvan kemoterapi aldı. Radyoterapi (XRT) sırasında gözlemlenen akut toksisiteler grad I-II olup tedavi iyi tolere edilmiştir. Medyan 16 aylık izlem sonucu lokal kontrol %100’dü. Hastaların 6’sında (%43) abdominal relaps, birinde (%7) uzak metastaz gelişti. İkisi hastalık dışı nedenlerle olmak üzere 9 olgu (%64) kaybedildi. 3BKRT ile lokal kontrolün sağlanması relaps şeklini değiştirmiş görünmektedir. Toraks dışı relapsların önlenememesi daha etkin sistemik tedavi gerekliliğini düşündürmektedir.

Anahtar Kelime:

Konular: Onkoloji

Malign plevral mezotelyomalı olgularda ekstra plevral pnömonektomi sonrası hemitorasik radyoterapinin etkinliği ve toksisitesi

Öz:

In this study, we evaluated the efficiency and the toxicity of three dimensional conformal hemithoracic radiotherapy (3DCHRT) after extra pleural pneumonectomy (EPP). The median age of 14 patients were 51 years (range, 33-61 years). Most commonly seen histopathology was epitheliod type (79%). According to American Joint Commission on Cancer (AJCC) 2002 staging system 9 cases (64%) were stage III. A total median dose of 50.4 Gy was applied to hemithoracic cavity. Eleven patients received adjuvant chemotherapy. 3DCHRT was generally well tolerated. The acute toxicities of 3DCHRT were grade I-II. After a median of 16 months follow-up, intrathoracic control was100%. Six patients (43%) developed abdominal relapse and one (7%) developed distant metastasis. Nine cases were dead with two of them being without the evidence of disease. Excellent local control with 3DCHRT after EPP seems to change the relapse patterns of MPM. More effective systemic treatment is needed to prevent the recurrences outside thorax.

Anahtar Kelime:

Konular: Onkoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Hurmuz P, akyol f, SELEK U, ÖZYİĞİT G, DOĞAN R, Ozdemir N, TAŞTEPE İ, CANGIR A, KARA M, DEMİRKAZIK F, Emri S (2010). The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. , 20 - 26.
Chicago	Hurmuz Pervin,akyol fadıl,SELEK UGUR,ÖZYİĞİT Gökhan,DOĞAN Rıza,Ozdemir Nezih,TAŞTEPE İrfan,CANGIR Ayten K.,KARA MURAT,DEMİRKAZIK Figen B.,Emri Salih The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. (2010): 20 - 26.
MLA	Hurmuz Pervin,akyol fadıl,SELEK UGUR,ÖZYİĞİT Gökhan,DOĞAN Rıza,Ozdemir Nezih,TAŞTEPE İrfan,CANGIR Ayten K.,KARA MURAT,DEMİRKAZIK Figen B.,Emri Salih The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. , 2010, ss.20 - 26.
AMA	Hurmuz P,akyol f,SELEK U,ÖZYİĞİT G,DOĞAN R,Ozdemir N,TAŞTEPE İ,CANGIR A,KARA M,DEMİRKAZIK F,Emri S The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. . 2010; 20 - 26.
Vancouver	Hurmuz P,akyol f,SELEK U,ÖZYİĞİT G,DOĞAN R,Ozdemir N,TAŞTEPE İ,CANGIR A,KARA M,DEMİRKAZIK F,Emri S The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. . 2010; 20 - 26.
IEEE	Hurmuz P,akyol f,SELEK U,ÖZYİĞİT G,DOĞAN R,Ozdemir N,TAŞTEPE İ,CANGIR A,KARA M,DEMİRKAZIK F,Emri S "The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma." , ss.20 - 26, 2010.
ISNAD	Hurmuz, Pervin vd. "The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma". (2010), 20-26.

APA	Hurmuz P, akyol f, SELEK U, ÖZYİĞİT G, DOĞAN R, Ozdemir N, TAŞTEPE İ, CANGIR A, KARA M, DEMİRKAZIK F, Emri S (2010). The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. Uluslararası Hematoloji-Onkoloji Dergisi, 20(1), 20 - 26.
Chicago	Hurmuz Pervin,akyol fadıl,SELEK UGUR,ÖZYİĞİT Gökhan,DOĞAN Rıza,Ozdemir Nezih,TAŞTEPE İrfan,CANGIR Ayten K.,KARA MURAT,DEMİRKAZIK Figen B.,Emri Salih The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. Uluslararası Hematoloji-Onkoloji Dergisi 20, no.1 (2010): 20 - 26.
MLA	Hurmuz Pervin,akyol fadıl,SELEK UGUR,ÖZYİĞİT Gökhan,DOĞAN Rıza,Ozdemir Nezih,TAŞTEPE İrfan,CANGIR Ayten K.,KARA MURAT,DEMİRKAZIK Figen B.,Emri Salih The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. Uluslararası Hematoloji-Onkoloji Dergisi, vol.20, no.1, 2010, ss.20 - 26.
AMA	Hurmuz P,akyol f,SELEK U,ÖZYİĞİT G,DOĞAN R,Ozdemir N,TAŞTEPE İ,CANGIR A,KARA M,DEMİRKAZIK F,Emri S The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. Uluslararası Hematoloji-Onkoloji Dergisi. 2010; 20(1): 20 - 26.
Vancouver	Hurmuz P,akyol f,SELEK U,ÖZYİĞİT G,DOĞAN R,Ozdemir N,TAŞTEPE İ,CANGIR A,KARA M,DEMİRKAZIK F,Emri S The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma. Uluslararası Hematoloji-Onkoloji Dergisi. 2010; 20(1): 20 - 26.
IEEE	Hurmuz P,akyol f,SELEK U,ÖZYİĞİT G,DOĞAN R,Ozdemir N,TAŞTEPE İ,CANGIR A,KARA M,DEMİRKAZIK F,Emri S "The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma." Uluslararası Hematoloji-Onkoloji Dergisi, 20, ss.20 - 26, 2010.
ISNAD	Hurmuz, Pervin vd. "The efficiency and toxicity of hemithoracic radiotherapy after extra pleural pneumonectomy in malign pleural mesothelioma". Uluslararası Hematoloji-Onkoloji Dergisi 20/1 (2010), 20-26.