Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar

ELYAS, Zeynep; Unal, Suheyla; EROL, Deniz

Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar

Deniz EROL, (Fırat Üniversitesi, Tıp Fakültesi, Biyoloji Anabilim Dalı, Elazığ, Türkiye)

Zeynep ELYAS, (İnönü Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Malatya, Türkiye)

Süheyla ÜNAL (İnönü Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Malatya, Türkiye)

Klinik Psikofarmakoloji Bülteni

19 1

Yıl: 2010 Cilt: 20 Sayı: 1 Sayfa Aralığı: 109 - 114 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar

Öz:

Epigenetik, DNA’nın nükleotid dizisinde herhangi bir değişim olmaksızın gen işlevinde kalıtsal olarak gerçekleşen değişikliklerin incelenmesi olarak tanımlanmaktadır. Hatalı epigenetik mekanizmalar, bazı hastalıklarda doğrudan rol oynamaktadır. Epigenetik düzenlenmenin depresyon, şizofreni, madde bağımlılığı, bilişsel işlev bozuklukları gibi ruhsal bozukluklarda ve nörogenezis, nöronal plastisite, öğrenme ve bellekte rol oynadığına dair çok sayıda veri bulunmaktadır. Bu derlemede, epigenetik mekanizmalar ve bu mekanizmaların psikiyatrik hastalıkların gelişimindeki rolü tartışıldı.

Anahtar Kelime:

Konular: Psikiyatri

Epigenetic mechanisms in the development of psychiatric disorders

Öz:

Epigenetics is defined as the study of heritable changes of gene function that occur without a change in the nucleotide sequence of DNA. Aberrant epigenetic mechanisms have been directly implicated in certain human diseases. There is much evidence that epigenetic regulation is involved in neurogenesis, neuronal plasticity, learning and memory, and in psychiatric disorders such as depression, addiction, schizophrenia, and cognitive dysfunction. In this review, the epigenetics mechanisms and their role in the development of psychiatric disorders were discussed

Anahtar Kelime:

Konular: Psikiyatri

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	EROL D, ELYAS Z, Unal S (2010). Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. , 109 - 114.
Chicago	EROL Deniz,ELYAS Zeynep,Unal Suheyla Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. (2010): 109 - 114.
MLA	EROL Deniz,ELYAS Zeynep,Unal Suheyla Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. , 2010, ss.109 - 114.
AMA	EROL D,ELYAS Z,Unal S Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. . 2010; 109 - 114.
Vancouver	EROL D,ELYAS Z,Unal S Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. . 2010; 109 - 114.
IEEE	EROL D,ELYAS Z,Unal S "Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar." , ss.109 - 114, 2010.
ISNAD	EROL, Deniz vd. "Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar". (2010), 109-114.

APA	EROL D, ELYAS Z, Unal S (2010). Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. Klinik Psikofarmakoloji Bülteni, 20(1), 109 - 114.
Chicago	EROL Deniz,ELYAS Zeynep,Unal Suheyla Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. Klinik Psikofarmakoloji Bülteni 20, no.1 (2010): 109 - 114.
MLA	EROL Deniz,ELYAS Zeynep,Unal Suheyla Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. Klinik Psikofarmakoloji Bülteni, vol.20, no.1, 2010, ss.109 - 114.
AMA	EROL D,ELYAS Z,Unal S Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. Klinik Psikofarmakoloji Bülteni. 2010; 20(1): 109 - 114.
Vancouver	EROL D,ELYAS Z,Unal S Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar. Klinik Psikofarmakoloji Bülteni. 2010; 20(1): 109 - 114.
IEEE	EROL D,ELYAS Z,Unal S "Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar." Klinik Psikofarmakoloji Bülteni, 20, ss.109 - 114, 2010.
ISNAD	EROL, Deniz vd. "Psikiyatrik hastalıkların gelişiminde epigenetik mekanizmalar". Klinik Psikofarmakoloji Bülteni 20/1 (2010), 109-114.