The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations

YAYLA, Sadık; Kılıç, Engin

The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations

Sadık YAYLA, (Kafkas Üniversitesi, Atatürk Sağlık Hizmetleri Meslek Yüksek Okulu, Kars, Türkiye)

Engin KILIÇ (Kafkas Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Kars, Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2010 Cilt: 16 Sayı: 5 Sayfa Aralığı: 835 - 840 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations

Öz:

Bu çalışmada spinal anestezide son yıllarda sıklıkla kullanılan izobarik ve hiperbarik bupivacaine HCl ile ropivacaine HCl’nin köpeklerdeki lokal ve sistemik bazı yan etkilerinin klinik, bazı hemodinamik ve histopatolojik olarak değerlendirilmesi amaçlanmıştır. Çalışmanın materyalini farklı cinsiyet, yaş ve vücut ağırlığına sahip sağlıklı 23 adet sokak köpeği ve spinal anestezi oluşturmak amacıyla bupivacaine hidroklorür içeren Marcaine® %0.5 (Astra Zenaca, Türkiye) ve Marcaine® Spinal Heavy %0.5 (Astra Zenaca, Türkiye) ile ropivacaine hidroklorid içeren Naropin® 7.5mg/ml (Astra Zenaca Almanya) oluşturdu. Her bir çalışma grubunda 5, kontrol grubunda ise 3 köpek yer alacak şekilde Aa (Marcaine), Ab (Marcaine® Spinal Heavy), Ba (Naropin®), Bb (Naropin® + Dekstroz) ve C (Dekstroz) olmak üzere 5 ayrı grup oluşturuldu. Tüm gruplarda anestezi süresince arteriyal kan basıncı, nabız ve solunum değerlerine bakılırken zaman zaman iğne pükürleri uygulandı. Hayvanlara birer haftalık hospitalizasyonu izleyerek ötenazi uygulandıktan sonra enjeksiyon uygulanan bölgeyi içeren spinal kord bölümü çıkarılarak histopatolojik olarak incelendi. Bu çalışmada yan etkiler bakımından ropivacaine HCl ile bupivacaine HCl arasında klinik, histopatolojik ve bazı hemodinamik parametrelerin değerlendirilme sonuçlarına göre kullanılan anesteziklerin herhangi bir yan etkisiyle karşılaşılmadı. Anestezi süresi ve derinliği bakımdan ise bupivacaine HCl’nin, ropivacaine HCl’ye göre oldukça üstün bir anestezi sağladığı ortaya konmuştur.

Anahtar Kelime: yan etkiler klinik görünüm solunum histopatoloji köpek anestezi kan basıncı nabız oranı omurga hemodinamik

Konular: Veterinerlik

Köpeklerde iki farklı konsantrasyondaki bupivacaine HCl ve ropivacaine HCl ile oluşturulan spinal anestezinin klinik, bazı hemodinamik ve histopatolojik etkilerinin karşılaştırılması

Öz:

The aim of this study was to evaluate the side effects of local and systemic clinical, histopathological and hemodynamics by use of isobaric and hyperbaric bupivacaine in different concentrations during spinal anesthesia which has been a common use within the past few years. The study material consisted of 23 healthy stray dogs with dissimilar sex, age and body weight as well as bupivacaine hydrochloride containing Marcaine® %0.5 (Astra Zenaca, Turkey) and Marcaine® Spinal Heavy %0.5 (Astra Zenaca, Turkey), and ropivacaine hydrochloride containing Naropin® 7.5mg/ml (Astra Zenaca, Germany) so as to create the state of spinal anesthesia. A total of 5 different groups were formed where each study group consisted of 5 dogs and the control group consisted of 3 dogs. The groups were as follows: Aa (Marcaine), Ab (Marcaine® Spinal Heavy), Ba (Naropin®), Bb (Naropin® + Dekstroz) and C (Dekstroz). During the anesthesia; blood pressure, pulse and respiratory rates were measured in all groups. Besides, needle punctures were applied from time to time. The animals were euthanized following a one-week long hospitalization. Then, the parts of the spinal cords on which injections were applied were taken off and investigated histopathologically. In this study no significant were observed with regard to the use of ropivacaine HCl and bupivacaine HCl and their clinical, hemodynamic and histopathologic side effects; on the other hand, bupivacaine HCl was found to be considerably superior to ropivacaine HCl regarding the anesthesia duration and depth.

Anahtar Kelime: histopathology dogs anaesthesia blood pressure pulse rate spine haemodynamics adverse effects clinical aspects respiration

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YAYLA S, Kılıç E (2010). The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. , 835 - 840.
Chicago	YAYLA Sadık,Kılıç Engin The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. (2010): 835 - 840.
MLA	YAYLA Sadık,Kılıç Engin The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. , 2010, ss.835 - 840.
AMA	YAYLA S,Kılıç E The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. . 2010; 835 - 840.
Vancouver	YAYLA S,Kılıç E The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. . 2010; 835 - 840.
IEEE	YAYLA S,Kılıç E "The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations." , ss.835 - 840, 2010.
ISNAD	YAYLA, Sadık - Kılıç, Engin. "The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations". (2010), 835-840.

APA	YAYLA S, Kılıç E (2010). The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 16(5), 835 - 840.
Chicago	YAYLA Sadık,Kılıç Engin The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 16, no.5 (2010): 835 - 840.
MLA	YAYLA Sadık,Kılıç Engin The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.16, no.5, 2010, ss.835 - 840.
AMA	YAYLA S,Kılıç E The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2010; 16(5): 835 - 840.
Vancouver	YAYLA S,Kılıç E The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2010; 16(5): 835 - 840.
IEEE	YAYLA S,Kılıç E "The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 16, ss.835 - 840, 2010.
ISNAD	YAYLA, Sadık - Kılıç, Engin. "The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 16/5 (2010), 835-840.