Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation
Yıl: 2022 Cilt: 27 Sayı: 2 Sayfa Aralığı: 335 - 344 Metin Dili: İngilizce DOI: 10.5578/flora.20229817 İndeks Tarihi: 10-08-2022
Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation
Öz: Introduction: BK polyomavirus (BKPyV) infections are an important cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The aim of the study was to assess the clinical characteristics of BKPyV infections after HSCT. Materials and Methods: The study was conducted in the adult HSCT clinics of a tertiary hospital in the central of Turkey between January 2017 and December 2019. Results: A total of 54 patients with HSCT were retrospectively evaluated and BKPyV disease was seen in 24 (44%). Hemorrhagic cystitis (HC) was seen in 19 (79.2%) of these patients. The median age was 42 and 50% of them were male. The most common underlying disease was acute myeloid leukemia. Five patients had autologous and 15 patients had allogeneic HSCT. The median time to engraftment was 15 days. Graft Versus Host disease (GVHD) was seen in seven patients. The median time elapsed to BKPyV disease after HSCT was found as 60 days. Nineteen patients with BKPyV disease had grade three and one patient had grade two HC. While BKPyV viremia was positive in five patients, viruria was detected in all patients. Eighteen of the patients with BKPyV disease were treated with cidofovir and 11 with ciprofloxacin. Four of the patients received intravesical cidofovir. The complete response was obtained in 53% of patients with BKPyV disease. Conclusion: We found that coincidental BKPyV disease and CMV activation may occur after HSCT with haematological malignancies. It is thought that follow-up in patients with suspected activation, especially in terms of hematuria and cystitis, may be important. Also, immunosuppressive agents used for GVHD prophylaxis can trigger BKPyV disease.
Anahtar Kelime: Hematopoetik Kök Hücre Nakli Sonrası BK Polyomavirüs İnfeksiyonu Gelişen Hastaların Klinik Özellikleri ve Risk Faktörleri
Öz: Giriş: BK polyomavirus (BKPyV) infeksiyonları hematopoietik kök hücre transplantasyonu (HKHT) sonrası önemli bir morbidite ve mortalite nedenidir. Bu çalışmanın amacı, HKHT sonrası gelişen BKPyV infeksiyonlarının klinik özelliklerini ve risk faktörlerini değerlendirmektir. Materyal ve Metod: Çalışma, Ocak 2017 ile Aralık 2019 tarihleri arasında Türkiye’nin merkezindeki üçüncü basamak bir hastanenin yetişkin HKHT kliniklerinde gerçekleştirilmiştir. Bulgular: HKHT’li toplam 54 hasta geriye dönük olarak değerlendirildi ve 24’ünde (%44) BKPyV infeksiyonu görüldü. Bu hastaların 19’unda (%79.2) hemorajik sistit görüldü. Ortanca yaş 42 olup, bunların %50’si erkekti. Altta yatan en yaygın hastalık akut miyeloid lösemiydi. Beş hastada otolog, 15 hastada allojenik HKHT vardı. Engraftmana kadar geçen medyan süre 15 gündü. Yedi hastada Graft Versus Host hastalığı (GVHD) tespit edildi. HKHT sonrası BKPyV hastalığına kadar geçen medyan süre 60 gün olarak bulundu. BKPyV hastalığı olan 19 hastada üçüncü derece ve bir hastada ikinci derece hemorajik sistit vardı. Beş hastada BKPyV viremi görülürken, tüm hastalarda virüri tespit edildi. BKPyV hastalığı olan hastaların 18’i cidofovir ve 11’i siprofloksasin ile tedavi edilmişti. Hastaların dördü intravezikal sidofovir almıştı. BKPyV hastalığı olan hastaların ise %53’ünde tam yanıt alınmıştı. Sonuç: Çalışma sonunda, hematolojik maligniteli hastalarda HKHT sonrası tesadüfi BKPyV hastalığı ve CMV aktivasyonunun ortaya çıkabileceği bulundu. Aktivasyon şüphesi olan hastalarda özellikle hematüri ve sistit açısından takibin önemli olabileceği düşünülmektedir. Ayrıca GVHD profilaksisi için kullanılan immünosupresif ajanlar da BKPyV hastalığını tetikleyebilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Kalin Unuvar G, TÜRE Z, Ulu Kılıç A, Keklik M, Cevahir F (2022). Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. , 335 - 344. 10.5578/flora.20229817 |
| Chicago | Kalin Unuvar Gamze,TÜRE Zeynep Ture,Ulu Kılıç Aysegul,Keklik Muzaffer,Cevahir Fatma Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. (2022): 335 - 344. 10.5578/flora.20229817 |
| MLA | Kalin Unuvar Gamze,TÜRE Zeynep Ture,Ulu Kılıç Aysegul,Keklik Muzaffer,Cevahir Fatma Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. , 2022, ss.335 - 344. 10.5578/flora.20229817 |
| AMA | Kalin Unuvar G,TÜRE Z,Ulu Kılıç A,Keklik M,Cevahir F Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. . 2022; 335 - 344. 10.5578/flora.20229817 |
| Vancouver | Kalin Unuvar G,TÜRE Z,Ulu Kılıç A,Keklik M,Cevahir F Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. . 2022; 335 - 344. 10.5578/flora.20229817 |
| IEEE | Kalin Unuvar G,TÜRE Z,Ulu Kılıç A,Keklik M,Cevahir F "Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation." , ss.335 - 344, 2022. 10.5578/flora.20229817 |
| ISNAD | Kalin Unuvar, Gamze vd. "Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation". (2022), 335-344. https://doi.org/10.5578/flora.20229817 |
| APA | Kalin Unuvar G, TÜRE Z, Ulu Kılıç A, Keklik M, Cevahir F (2022). Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 27(2), 335 - 344. 10.5578/flora.20229817 |
| Chicago | Kalin Unuvar Gamze,TÜRE Zeynep Ture,Ulu Kılıç Aysegul,Keklik Muzaffer,Cevahir Fatma Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 27, no.2 (2022): 335 - 344. 10.5578/flora.20229817 |
| MLA | Kalin Unuvar Gamze,TÜRE Zeynep Ture,Ulu Kılıç Aysegul,Keklik Muzaffer,Cevahir Fatma Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, vol.27, no.2, 2022, ss.335 - 344. 10.5578/flora.20229817 |
| AMA | Kalin Unuvar G,TÜRE Z,Ulu Kılıç A,Keklik M,Cevahir F Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2022; 27(2): 335 - 344. 10.5578/flora.20229817 |
| Vancouver | Kalin Unuvar G,TÜRE Z,Ulu Kılıç A,Keklik M,Cevahir F Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2022; 27(2): 335 - 344. 10.5578/flora.20229817 |
| IEEE | Kalin Unuvar G,TÜRE Z,Ulu Kılıç A,Keklik M,Cevahir F "Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation." Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 27, ss.335 - 344, 2022. 10.5578/flora.20229817 |
| ISNAD | Kalin Unuvar, Gamze vd. "Characteristics and Risk Factors for Patients with BK Polyomavirus Infection After Hematopoietic Stem Cell Transplantation". Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 27/2 (2022), 335-344. https://doi.org/10.5578/flora.20229817 |
